Identification
HMDB Protein ID CDBP00185
Secondary Accession Numbers Not Available
Name NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Description Not Available
Synonyms
  1. CI-B16.6
  2. Cell death regulatory protein GRIM-19
  3. Complex I-B16.6
  4. GRIM-19
  5. Gene associated with retinoic and IFN-induced mortality 19 protein
  6. Gene associated with retinoic and interferon-induced mortality 19 protein
  7. NADH-ubiquinone oxidoreductase B16.6 subunit
Gene Name NDUFA13
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Single-pass membrane protein
  3. Mitochondrion inner membrane
  4. Matrix side
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.2
SNPs NDUFA13
Gene Sequence
>435 bp
ATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGAC
TACAAACGGAACTTGCCGCGTCGAGGACTGTCGGGCTACAGCATGCTGGCCATAGGGATT
GGAACCCTGATCTACGGGCACTGGAGCATAATGAAGTGGAACCGTGAGCGCAGGCGCCTA
CAAATCGAGGACTTCGAGGCTCGCATCGCGCTGTTGCCACTGTTACAGGCAGAAACCGAC
CGGAGGACCTTGCAGATGCTTCGGGAGAACCTGGAGGAGGAGGCCATCATCATGAAGGAC
GTGCCCGACTGGAAGGTGGGGGAGTCTGTGTTCCACACAACCCGCTGGGTGCCCCCCTTG
ATCGGGGAGCTGTACGGGCTGCGCACCACAGAGGAGGCTCTCCATGCCAGCCACGGCTTC
ATGTGGTACACGTAG
Protein Properties
Number of Residues 144
Molecular Weight 16698.2
Theoretical pI 8.84
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["30-51"]
Protein Sequence
>NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRL
QIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPL
IGELYGLRTTEEALHASHGFMWYT
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9P0J0
UniProtKB/Swiss-Prot Entry Name NDUAD_HUMAN
PDB IDs Not Available
GenBank Gene ID AF286697
GeneCard ID NDUFA13
GenAtlas ID NDUFA13
HGNC ID HGNC:17194
References
General References Not Available