Showing Protein ADP-ribosyl cyclase 1 (CDBP00861)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 compounds
Identification
HMDB Protein ID CDBP00861
Secondary Accession Numbers Not Available
Name ADP-ribosyl cyclase 1
Description Not Available
Synonyms
  1. CD38 antigen
  2. Cyclic ADP-ribose hydrolase 1
  3. T10
  4. cADPr hydrolase 1
Gene Name CD38
Protein Type Enzyme
Biological Properties
General Function Involved in NAD+ nucleosidase activity
Specific Function Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
GO Classification
Biological Process
positive regulation of insulin secretion
response to drug
negative regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
long term synaptic depression
apoptotic signaling pathway
positive regulation of cell growth
B cell receptor signaling pathway
positive regulation of B cell proliferation
elevation of cytosolic calcium ion concentration
response to estradiol stimulus
female pregnancy
response to hypoxia
negative regulation of bone resorption
positive regulation of vasoconstriction
response to hydroperoxide
response to interleukin-1
response to progesterone stimulus
response to retinoic acid
negative regulation of apoptotic process
Cellular Component
cell surface
plasma membrane
nucleus
integral to membrane
Function
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing n-glycosyl compounds
nad+ nucleosidase activity
binding
catalytic activity
hydrolase activity
Molecular Function
phosphorus-oxygen lyase activity
NAD+ nucleosidase activity
nucleotide binding
Process
metabolic process
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein
Pathways
Gene Properties
Chromosome Location 4
Locus 4p15
SNPs CD38
Gene Sequence 
>903 bp
ATGGCCAACTGCGAGTTCAGCCCGGTGTCCGGGGACAAACCCTGCTGCCGGCTCTCTAGG
AGAGCCCAACTCTGTCTTGGCGTCAGTATCCTGGTCCTGATCCTCGTCGTGGTGCTCGCG
GTGGTCGTCCCGAGGTGGCGCCAGCAGTGGAGCGGTCCGGGCACCACCAAGCGCTTTCCC
GAGACCGTCCTGGCGCGATGCGTCAAGTACACTGAAATTCATCCTGAGATGAGACATGTA
GACTGCCAAAGTGTATGGGATGCTTTCAAGGGTGCATTTATTTCAAAACATCCTTGCAAC
ATTACTGAAGAAGACTATCAGCCACTAATGAAGTTGGGAACTCAGACCGTACCTTGCAAC
AAGATTCTTCTTTGGAGCAGAATAAAAGATCTGGCCCATCAGTTCACACAGGTCCAGCGG
GACATGTTCACCCTGGAGGACACGCTGCTAGGCTACCTTGCTGATGACCTCACATGGTGT
GGTGAATTCAACACTTCCAAAATAAACTATCAATCTTGCCCAGACTGGAGAAAGGACTGC
AGCAACAACCCTGTTTCAGTATTCTGGAAAACGGTTTCCCGCAGGTTTGCAGAAGCTGCC
TGTGATGTGGTCCATGTGATGCTCAATGGATCCCGCAGTAAAATCTTTGACAAAAACAGC
ACTTTTGGGAGTGTGGAAGTCCATAATTTGCAACCAGAGAAGGTTCAGACACTAGAGGCC
TGGGTGATACATGGTGGAAGAGAAGATTCCAGAGACTTATGCCAGGATCCCACCATAAAA
GAGCTGGAATCGATTATAAGCAAAAGGAATATTCAATTTTCCTGCAAGAATATCTACAGA
CCTGACAAGTTTCTTCAGTGTGTGAAAAATCCTGAGGATTCATCTTGCACATCTGAGATC
TGA
Protein Properties
Number of Residues 300
Molecular Weight 34328.145
Theoretical pI 7.665
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>ADP-ribosyl cyclase 1
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
GenBank ID Protein 14044085
UniProtKB/Swiss-Prot ID P28907
UniProtKB/Swiss-Prot Entry Name CD38_HUMAN
PDB IDs
GenBank Gene ID BC007964
GeneCard ID CD38
GenAtlas ID CD38
HGNC ID HGNC:1667
References
General References Not Available