| Identification |
|---|
| HMDB Protein ID
| CDBP00861 |
| Secondary Accession Numbers
| Not Available |
| Name
| ADP-ribosyl cyclase 1 |
| Description
| Not Available |
| Synonyms
|
- CD38 antigen
- Cyclic ADP-ribose hydrolase 1
- T10
- cADPr hydrolase 1
|
| Gene Name
| CD38 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ nucleosidase activity |
| Specific Function
| Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
|
| GO Classification
|
| Biological Process |
| positive regulation of insulin secretion |
| response to drug |
| negative regulation of transcription, DNA-dependent |
| positive regulation of transcription, DNA-dependent |
| long term synaptic depression |
| apoptotic signaling pathway |
| positive regulation of cell growth |
| B cell receptor signaling pathway |
| positive regulation of B cell proliferation |
| elevation of cytosolic calcium ion concentration |
| response to estradiol stimulus |
| female pregnancy |
| response to hypoxia |
| negative regulation of bone resorption |
| positive regulation of vasoconstriction |
| response to hydroperoxide |
| response to interleukin-1 |
| response to progesterone stimulus |
| response to retinoic acid |
| negative regulation of apoptotic process |
| Cellular Component |
| cell surface |
| plasma membrane |
| nucleus |
| integral to membrane |
| Function |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing n-glycosyl compounds |
| nad+ nucleosidase activity |
| binding |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| phosphorus-oxygen lyase activity |
| NAD+ nucleosidase activity |
| nucleotide binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Calcium signaling pathway | Not Available |  | | Hematopoietic cell lineage | Not Available |  | | Salivary secretion | Not Available |  | | Pancreatic secretion | Not Available |  | | Epstein-Barr virus infection | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p15 |
| SNPs
| CD38 |
| Gene Sequence
|
>903 bp
ATGGCCAACTGCGAGTTCAGCCCGGTGTCCGGGGACAAACCCTGCTGCCGGCTCTCTAGG
AGAGCCCAACTCTGTCTTGGCGTCAGTATCCTGGTCCTGATCCTCGTCGTGGTGCTCGCG
GTGGTCGTCCCGAGGTGGCGCCAGCAGTGGAGCGGTCCGGGCACCACCAAGCGCTTTCCC
GAGACCGTCCTGGCGCGATGCGTCAAGTACACTGAAATTCATCCTGAGATGAGACATGTA
GACTGCCAAAGTGTATGGGATGCTTTCAAGGGTGCATTTATTTCAAAACATCCTTGCAAC
ATTACTGAAGAAGACTATCAGCCACTAATGAAGTTGGGAACTCAGACCGTACCTTGCAAC
AAGATTCTTCTTTGGAGCAGAATAAAAGATCTGGCCCATCAGTTCACACAGGTCCAGCGG
GACATGTTCACCCTGGAGGACACGCTGCTAGGCTACCTTGCTGATGACCTCACATGGTGT
GGTGAATTCAACACTTCCAAAATAAACTATCAATCTTGCCCAGACTGGAGAAAGGACTGC
AGCAACAACCCTGTTTCAGTATTCTGGAAAACGGTTTCCCGCAGGTTTGCAGAAGCTGCC
TGTGATGTGGTCCATGTGATGCTCAATGGATCCCGCAGTAAAATCTTTGACAAAAACAGC
ACTTTTGGGAGTGTGGAAGTCCATAATTTGCAACCAGAGAAGGTTCAGACACTAGAGGCC
TGGGTGATACATGGTGGAAGAGAAGATTCCAGAGACTTATGCCAGGATCCCACCATAAAA
GAGCTGGAATCGATTATAAGCAAAAGGAATATTCAATTTTCCTGCAAGAATATCTACAGA
CCTGACAAGTTTCTTCAGTGTGTGAAAAATCCTGAGGATTCATCTTGCACATCTGAGATC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 300 |
| Molecular Weight
| 34328.145 |
| Theoretical pI
| 7.665 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ADP-ribosyl cyclase 1
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
|
| External Links |
|---|
| GenBank ID Protein
| 14044085 |
| UniProtKB/Swiss-Prot ID
| P28907 |
| UniProtKB/Swiss-Prot Entry Name
| CD38_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC007964 |
| GeneCard ID
| CD38 |
| GenAtlas ID
| CD38 |
| HGNC ID
| HGNC:1667 |
| References |
|---|
| General References
| Not Available |