| Identification |
|---|
| HMDB Protein ID
| CDBP04070 |
| Secondary Accession Numbers
| Not Available |
| Name
| Estradiol 17-beta-dehydrogenase 12 |
| Description
| Not Available |
| Synonyms
|
- 17-beta-HSD 12
- 17-beta-hydroxysteroid dehydrogenase 12
- 3-ketoacyl-CoA reductase
- KAR
|
| Gene Name
| HSD17B12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| extracellular matrix organization |
| positive regulation of cell-substrate adhesion |
| fatty acid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| estrogen biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| extracellular matrix |
| integral to membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| estradiol 17-beta-dehydrogenase activity |
| nucleotide binding |
| heparin binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | estrogen biosynthesis | Not Available | Not Available | | Fatty acid elongation | Not Available |  | | Steroid hormone biosynthesis | Not Available |  | | Biosynthesis of unsaturated fatty acids | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p11.2 |
| SNPs
| HSD17B12 |
| Gene Sequence
|
>939 bp
ATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCGGCGCGGGCACCGTGGCC
TACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGG
AATGAGGCGGGGGTCGGCCCGGGGCTCGGAGAGTGGGCAGTTGTCACAGGTAGTACTGAT
GGAATTGGAAAATCATATGCAGAAGAGTTAGCAAAGCATGGAATGAAGGTTGTCCTTATC
AGCAGATCAAAGGATAAACTTGACCAGGTTTCCAGTGAAATAAAAGAAAAATTCAAAGTG
GAGACAAGAACCATTGCTGTTGACTTTGCATCAGAAGATATTTATGATAAAATTAAAACA
GGCTTGGCTGGTCTTGAAATCGGCATCTTAGTGAACAACGTGGGAATGTCGTATGAGTAT
CCTGAATACTTTTTGGATGTTCCTGACTTGGACAATGTGATCAAGAAAATGATAAATATT
AATATTCTTTCTGTTTGTAAGATGACACAATTGGTACTGCCTGGCATGGTGGAAAGATCC
AAAGGGGCTATTCTGAACATTTCATCTGGCAGTGGCATGCTCCCTGTCCCACTCTTGACC
ATCTATTCTGCAACCAAGACTTTTGTAGATTTCTTCTCTCAGTGCCTCCATGAGGAGTAT
AGGAGCAAGGGCGTCTTTGTGCAGAGTGTCCTGCCATACTTCGTAGCTACAAAACTGGCT
AAAATCCGGAAGCCAACTTTGGATAAGCCCTCTCCGGAGACGTTTGTGAAGTCTGCAATT
AAAACAGTCGGCCTGCAATCCCGAACCAATGGATACCTGATCCATGCTCTTATGGGCTCG
ATAATCTCAAACCTGCCTTCTTGGATTTATTTGAAAATAGTCATGAATATGAACAAGTCT
ACACGGGCTCACTATCTGAAGAAAACCAAGAAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 312 |
| Molecular Weight
| 34323.875 |
| Theoretical pI
| 9.323 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Estradiol 17-beta-dehydrogenase 12
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD
GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT
GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS
KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA
KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS
TRAHYLKKTKKN
|
| External Links |
|---|
| GenBank ID Protein
| 5531815 |
| UniProtKB/Swiss-Prot ID
| Q53GQ0 |
| UniProtKB/Swiss-Prot Entry Name
| DHB12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF078850 |
| GeneCard ID
| HSD17B12 |
| GenAtlas ID
| HSD17B12 |
| HGNC ID
| HGNC:18646 |
| References |
|---|
| General References
| Not Available |