Cannabis Compound Database: Showing Protein 3-hydroxyacyl-CoA dehydrogenase type-2 (CDBP00371)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00371

Secondary Accession Numbers

Not Available

Name

3-hydroxyacyl-CoA dehydrogenase type-2

Description

Not Available

Synonyms

17-beta-HSD 10
17-beta-hydroxysteroid dehydrogenase 10
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
3-hydroxyacyl-CoA dehydrogenase type II
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
Mitochondrial RNase P protein 2
Mitochondrial ribonuclease P protein 2
Short-chain type dehydrogenase/reductase XH98G2
Type II HADH

Gene Name

HSD17B10

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

GO Classification

Biological Process
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
Leydig cell differentiation
cell aging
tRNA processing
protein homotetramerization
lipid metabolic process
Cellular Component
mitochondrial matrix
endoplasmic reticulum
plasma membrane
mitochondrial inner membrane
Function
catalytic activity
oxidoreductase activity
binding
Molecular Function
NAD binding
beta-amyloid binding
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
acetoacetyl-CoA reductase activity
cholate 7-alpha-dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
steroid binding
3-hydroxyacyl-CoA dehydrogenase activity
Process
metabolic process
physiological process
metabolism
oxidation reduction

Cellular Location

Mitochondrion
Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
Fatty Acid Elongation In Mitochondria
Alzheimer's disease	Not Available
Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD)		Not Available
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids		Not Available
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD)		Not Available

Gene Properties

Chromosome Location

Locus

Xp11.2

SNPs

HSD17B10

Gene Sequence

>786 bp
ATGGCAGCAGCGTGTCGGAGCGTGAAGGGCCTGGTGGCGGTAATAACCGGAGGAGCCTCG
GGCCTGGGCCTGGCCACGGCGGAGCGACTTGTGGGGCAGGGAGCCTCTGCTGTGCTTCTG
GACCTGCCCAACTCGGGTGGGGAGGCCCAAGCCAAGAAGTTAGGAAACAACTGCGTTTTC
GCCCCAGCCGACGTGACCTCTGAGAAGGATGTGCAAACAGCTCTGGCTCTAGCAAAAGGA
AAGTTTGGCCGTGTGGATGTAGCTGTCAACTGTGCAGGCATCGCGGTGGCTAGCAAGACG
TACAACTTAAAGAAGGGCCAGACCCATACCTTGGAAGACTTCCAGCGAGTTCTTGATGTG
AATCTCATGGGCACCTTCAATGTGATCCGCCTGGTGGCTGGTGAGATGGGCCAGAATGAA
CCAGACCAGGGAGGCCAACGTGGGGTCATCATCAACACTGCCAGTGTGGCTGCCTTCGAG
GGTCAGGTTGGACAAGCTGCATACTCTGCTTCCAAGGGGGGAATAGTGGGCATGACACTG
CCCATTGCTCGGGATCTGGCTCCCATAGGTATCCGGGTGATGACCATTGCCCCAGGTCTG
TTTGGCACCCCACTGCTGACCAGCCTCCCAGAGAAAGTGTGCAACTTCTTGGCCAGCCAA
GTGCCCTTCCCTAGCCGACTGGGTGACCCTGCTGAGTATGCTCACCTCGTACAGGCCATC
ATCGAGAACCCATTCCTCAATGGAGAGGTCATCCGGCTGGATGGGGCCATTCGTATGCAG
CCTTGA

Protein Properties

Number of Residues

261

Molecular Weight

25983.695

Theoretical pI

7.211

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-hydroxyacyl-CoA dehydrogenase type-2
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
IENPFLNGEVIRLDGAIRMQP

External Links

GenBank ID Protein

57210025

UniProtKB/Swiss-Prot ID

Q99714

UniProtKB/Swiss-Prot Entry Name

HCD2_HUMAN

PDB IDs