| Identification |
|---|
| HMDB Protein ID
| CDBP04089 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD-dependent protein deacetylase sirtuin-2 |
| Description
| Not Available |
| Synonyms
|
- SIR2-like protein 2
- Regulatory protein SIR2 homolog 2
|
| Gene Name
| SIRT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.
|
| GO Classification
|
| Biological Process |
| negative regulation of striated muscle tissue development |
| regulation of exit from mitosis |
| cell division |
| response to redox state |
| protein ADP-ribosylation |
| chromatin silencing at telomere |
| regulation of phosphorylation |
| proteasomal ubiquitin-dependent protein catabolic process |
| mitosis |
| chromatin silencing at rDNA |
| Cellular Component |
| cytoplasm |
| chromatin silencing complex |
| microtubule |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| nad or nadh binding |
| nad binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Molecular Function |
| metal ion binding |
| zinc ion binding |
| NAD+ binding |
| NAD-dependent histone deacetylase activity |
| tubulin deacetylase activity |
| ubiquitin binding |
| Process |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid deacetylation |
| gene silencing |
| chromatin silencing |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| post-translational protein modification |
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13 |
| SNPs
| SIRT2 |
| Gene Sequence
|
>1170 bp
ATGGCAGAGCCAGACCCCTCTCACCCTCTGGAGACCCAGGCAGGGAAGGTGCAGGAGGCT
CAGGACTCAGATTCAGACTCTGAGGGAGGAGCCGCTGGTGGAGAAGCAGACATGGACTTC
CTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGGCAGCCAGAAGGAGCGTCTGCTGGAC
GAGCTGACCTTGGAAGGGGTGGCCCGGTACATGCAGAGCGAACGCTGTCGCAGAGTCATC
TGTTTGGTGGGAGCTGGAATCTCCACATCCGCAGGCATCCCCGACTTTCGCTCTCCATCC
ACCGGCCTCTATGACAACCTAGAGAAGTACCATCTTCCCTACCCAGAGGCCATCTTTGAG
ATCAGCTATTTCAAGAAACATCCGGAACCCTTCTTCGCCCTCGCCAAGGAACTCTATCCT
GGGCAGTTCAAGCCAACCATCTGTCACTACTTCATGCGCCTGCTGAAGGACAAGGGGCTA
CTCCTGCGCTGCTACACGCAGAACATAGATACCCTGGAGCGAATAGCCGGGCTGGAACAG
GAGGACTTGGTGGAGGCGCACGGCACCTTCTACACATCACACTGCGTCAGCGCCAGCTGC
CGGCACGAATACCCGCTAAGCTGGATGAAAGAGAAGATCTTCTCTGAGGTGACGCCCAAG
TGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCA
GCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATG
GGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACC
CCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATT
ATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGG
CTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAG
CTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTC
CCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCC
AGGACAACAGAGAGGGAGAAACCCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 389 |
| Molecular Weight
| 26711.565 |
| Theoretical pI
| 6.524 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-2
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
| External Links |
|---|
| GenBank ID Protein
| 13400020 |
| UniProtKB/Swiss-Prot ID
| Q8IXJ6 |
| UniProtKB/Swiss-Prot Entry Name
| SIRT2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF083107 |
| GeneCard ID
| SIRT2 |
| GenAtlas ID
| SIRT2 |
| HGNC ID
| HGNC:10886 |
| References |
|---|
| General References
| Not Available |