Identification
HMDB Protein ID CDBP00725
Secondary Accession Numbers Not Available
Name Alcohol dehydrogenase class-3
Description Not Available
Synonyms
  1. Alcohol dehydrogenase 5
  2. Alcohol dehydrogenase class chi chain
  3. Alcohol dehydrogenase class-III
  4. FALDH
  5. FDH
  6. GSH-FDH
  7. Glutathione-dependent formaldehyde dehydrogenase
  8. S-(hydroxymethyl)glutathione dehydrogenase
Gene Name ADH5
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
GO Classification
Biological Process
retinoid metabolic process
formaldehyde catabolic process
peptidyl-cysteine S-nitrosylation
positive regulation of blood pressure
respiratory system process
response to lipopolysaccharide
response to nitrosative stress
response to redox state
ethanol oxidation
aging
ethanol catabolic process
Cellular Component
mitochondrion
nucleus
Function
catalytic activity
transition metal ion binding
zinc ion binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
s-(hydroxymethyl)glutathione dehydrogenase activity
ion binding
cation binding
metal ion binding
binding
Molecular Function
electron carrier activity
alcohol dehydrogenase (NAD) activity
metal ion binding
formaldehyde dehydrogenase activity
S-(hydroxymethyl)glutathione dehydrogenase activity
fatty acid binding
zinc ion binding
nucleotide binding
Process
small molecule metabolic process
alcohol metabolic process
oxidation reduction
monohydric alcohol metabolic process
ethanol metabolic process
ethanol oxidation
metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 4
Locus 4q23
SNPs ADH5
Gene Sequence
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA
Protein Properties
Number of Residues 374
Molecular Weight 39723.945
Theoretical pI 7.488
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Alcohol dehydrogenase class-3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI
GenBank ID Protein 178134
UniProtKB/Swiss-Prot ID P11766
UniProtKB/Swiss-Prot Entry Name ADHX_HUMAN
PDB IDs
GenBank Gene ID M30471
GeneCard ID ADH5
GenAtlas ID ADH5
HGNC ID HGNC:253
References
General References Not Available