Cannabis Compound Database: Showing Protein Alcohol dehydrogenase class-3 (CDBP00725)

Identification Biological properties Gene properties Protein properties External links References XML Show 13 compounds

Identification

HMDB Protein ID

CDBP00725

Secondary Accession Numbers

Not Available

Name

Alcohol dehydrogenase class-3

Description

Not Available

Synonyms

Alcohol dehydrogenase 5
Alcohol dehydrogenase class chi chain
Alcohol dehydrogenase class-III
FALDH
FDH
GSH-FDH
Glutathione-dependent formaldehyde dehydrogenase
S-(hydroxymethyl)glutathione dehydrogenase

Gene Name

ADH5

Protein Type

Enzyme

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

GO Classification

Biological Process
peptidyl-cysteine S-nitrosylation
positive regulation of blood pressure
respiratory system process
response to lipopolysaccharide
response to nitrosative stress
response to redox state
ethanol oxidation
aging
ethanol catabolic process
retinoid metabolic process
formaldehyde catabolic process
Cellular Component
mitochondrion
nucleus
Function
zinc ion binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
s-(hydroxymethyl)glutathione dehydrogenase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
Molecular Function
electron carrier activity
alcohol dehydrogenase (NAD) activity
metal ion binding
formaldehyde dehydrogenase activity
S-(hydroxymethyl)glutathione dehydrogenase activity
fatty acid binding
zinc ion binding
nucleotide binding
Process
oxidation reduction
monohydric alcohol metabolic process
ethanol metabolic process
ethanol oxidation
metabolic process
small molecule metabolic process
alcohol metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycolysis / Gluconeogenesis	Not Available
Metabolism of xenobiotics by cytochrome P450	Not Available
Drug metabolism - cytochrome P450	Not Available
Chemical carcinogenesis	Not Available

Gene Properties

Chromosome Location

Locus

4q23

SNPs

ADH5

Gene Sequence

>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA

Protein Properties

Number of Residues

374

Molecular Weight

39723.945

Theoretical pI

7.488

Pfam Domain Function

ADH_zinc_N (PF00107 )
ADH_N (PF08240 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Alcohol dehydrogenase class-3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

External Links

GenBank ID Protein

178134

UniProtKB/Swiss-Prot ID

P11766

UniProtKB/Swiss-Prot Entry Name

ADHX_HUMAN

PDB IDs

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Not Available