Identification |
HMDB Protein ID
| CDBP00725 |
Secondary Accession Numbers
| Not Available |
Name
| Alcohol dehydrogenase class-3 |
Description
| Not Available |
Synonyms
|
- Alcohol dehydrogenase 5
- Alcohol dehydrogenase class chi chain
- Alcohol dehydrogenase class-III
- FALDH
- FDH
- GSH-FDH
- Glutathione-dependent formaldehyde dehydrogenase
- S-(hydroxymethyl)glutathione dehydrogenase
|
Gene Name
| ADH5 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in zinc ion binding |
Specific Function
| Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
|
GO Classification
|
Biological Process |
retinoid metabolic process |
formaldehyde catabolic process |
peptidyl-cysteine S-nitrosylation |
positive regulation of blood pressure |
respiratory system process |
response to lipopolysaccharide |
response to nitrosative stress |
response to redox state |
ethanol oxidation |
aging |
ethanol catabolic process |
Cellular Component |
mitochondrion |
nucleus |
Function |
catalytic activity |
transition metal ion binding |
zinc ion binding |
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
oxidoreductase activity, acting on ch-oh group of donors |
oxidoreductase activity |
s-(hydroxymethyl)glutathione dehydrogenase activity |
ion binding |
cation binding |
metal ion binding |
binding |
Molecular Function |
electron carrier activity |
alcohol dehydrogenase (NAD) activity |
metal ion binding |
formaldehyde dehydrogenase activity |
S-(hydroxymethyl)glutathione dehydrogenase activity |
fatty acid binding |
zinc ion binding |
nucleotide binding |
Process |
small molecule metabolic process |
alcohol metabolic process |
oxidation reduction |
monohydric alcohol metabolic process |
ethanol metabolic process |
ethanol oxidation |
metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycolysis / Gluconeogenesis | Not Available | | Metabolism of xenobiotics by cytochrome P450 | Not Available | | Drug metabolism - cytochrome P450 | Not Available | | Chemical carcinogenesis | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q23 |
SNPs
| ADH5 |
Gene Sequence
|
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA
|
Protein Properties |
Number of Residues
| 374 |
Molecular Weight
| 39723.945 |
Theoretical pI
| 7.488 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Alcohol dehydrogenase class-3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI
|
External Links |
GenBank ID Protein
| 178134 |
UniProtKB/Swiss-Prot ID
| P11766 |
UniProtKB/Swiss-Prot Entry Name
| ADHX_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| M30471 |
GeneCard ID
| ADH5 |
GenAtlas ID
| ADH5 |
HGNC ID
| HGNC:253 |
References |
General References
| Not Available |