| Identification |
|---|
| HMDB Protein ID
| CDBP02354 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-lactate dehydrogenase A chain |
| Description
| Not Available |
| Synonyms
|
- Cell proliferation-inducing gene 19 protein
- LDH muscle subunit
- LDH-A
- LDH-M
- Renal carcinoma antigen NY-REN-59
|
| Gene Name
| LDHA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| cellular response to extracellular stimulus |
| glycolysis |
| cellular carbohydrate metabolic process |
| pyruvate metabolic process |
| Cellular Component |
| cytosol |
| mitochondrion |
| flagellum |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| lactate dehydrogenase activity |
| l-lactate dehydrogenase activity |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| catalytic activity |
| Molecular Function |
| L-lactate dehydrogenase activity |
| nucleotide binding |
| Process |
| oxidation reduction |
| glucose catabolic process |
| glycolysis |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| cellular carbohydrate metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | pyruvate fermentation to lactate | Not Available | Not Available | | Glycolysis / Gluconeogenesis | Not Available |  | | Cysteine and methionine metabolism | Not Available |  | | HIF-1 signaling pathway | Not Available |  | | Glutaminolysis and Cancer |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.4 |
| SNPs
| LDHA |
| Gene Sequence
|
>999 bp
ATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAG
AATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTA
ATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGA
GAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGC
AAAGACTATAATGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAG
CAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCGTAACGTGAACATATTTAAATTCATC
ATTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTG
GATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTGATGGGGGAAAGGCTGGGAGTT
CACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTA
TGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTAGGGACT
GATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAG
GTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGATTTGGCA
GAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAGGGTCTT
TACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAATGGAATC
TCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCA
GATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 332 |
| Molecular Weight
| 30204.975 |
| Theoretical pI
| 7.151 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-lactate dehydrogenase A chain
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
|
| External Links |
|---|
| GenBank ID Protein
| 34313 |
| UniProtKB/Swiss-Prot ID
| P00338 |
| UniProtKB/Swiss-Prot Entry Name
| LDHA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X02152 |
| GeneCard ID
| LDHA |
| GenAtlas ID
| LDHA |
| HGNC ID
| HGNC:6535 |
| References |
|---|
| General References
| Not Available |