Identification |
HMDB Protein ID
| CDBP04076 |
Secondary Accession Numbers
| Not Available |
Name
| Poly [ADP-ribose] polymerase 10 |
Description
| Not Available |
Synonyms
|
- PARP-10
- ADP-ribosyltransferase diphtheria toxin-like 10
- ARTD10
|
Gene Name
| PARP10 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotide binding |
Specific Function
| May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
|
GO Classification
|
Biological Process |
regulation of chromatin assembly |
negative regulation of fibroblast proliferation |
protein poly-ADP-ribosylation |
Cellular Component |
Golgi apparatus |
nucleus |
Function |
catalytic activity |
transferase activity |
nad+ adp-ribosyltransferase activity |
transferase activity, transferring pentosyl groups |
transferase activity, transferring glycosyl groups |
Molecular Function |
NAD+ ADP-ribosyltransferase activity |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- nucleolus
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 8 |
Locus
| 8q24.3 |
SNPs
| PARP10 |
Gene Sequence
|
>3078 bp
ATGGTTGCAATGGCGGAGGCAGAGGCAGGGGTGGCAGTGGAGGTCCGTGGACTGCCCCCT
GCCGTGCCCGACGAGCTGCTCACTCTCTACTTTGAAAACCGCCGACGCTCTGGAGGGGGA
CCTGTGTTGAGCTGGCAGAGACTGGGCTGTGGGGGCGTCCTCACCTTCAGAGAGCCTGCA
GACGCCGAGAGGGTCTTGGCCCAGGCAGATCACGAACTACATGGTGCCCAGCTGAGCCTG
CGGCCAGCTCCACCACGAGCCCCTGCACGCCTGCTGCTCCAAGGACTGCCCCCTGGCACC
ACGCCCCAGCGCTTGGAGCAGCATGTCCAGGCCTTGCTGCGGGCCTCGGGGCTCCCAGTA
CAGCCTTGCTGTGCCTTGGCCAGCCCCCGGCCAGACCGGGCTCTGGTCCAGTTGCCCAAG
CCCCTTTCTGAGGCAGATGTCCGTGTCCTGGAGGAGCAGGCCCAGAATCTGGGCCTGGAG
GGGACCTTGGTGTCCCTGGCCCGGGTTCCCCAGGCCCGAGCGGTGCGTGTGGTGGGGGAT
GGTGCCTCTGTGGACCTGCTGTTGCTGGAGTTGTACCTGGAGAATGAGCGCCGCAGTGGT
GGGGGGCCCCTGGAGGACCTGCAACGCCTACCCGGGCCCCTGGGCACTGTTGCCTCCTTC
CAGCAGTGGCAAGTGGCAGAACGAGTGTTGCAGCAGGAGCACCGGTTGCAGGGCTCAGAG
CTGAGCCTTGTCCCCCACTACGACATCCTGGAGCCCGAGGAGCTGGCTGAGAACACCAGT
GGAGGGGACCACCCGTCCACCCAGGGGCCTAGGGCTACCAAGCATGCTCTCCTGAGGACC
GGAGGGTTGGTGACGGCTCTGCAGGGTGCAGGGACTGTGACAATGGGCTCTGGCGAGGAA
CCAGGGCAGTCAGGGGCCTCTCTGAGGACAGGTCCCATGGTGCAGGGTAGAGGGATTATG
ACAACAGGCTCTGGCCAGGAACCAGGGCAGTCAGGGACCTCTCTGAGGACAGGTCCCATG
GGGTCTCTGGGACAGGCAGAGCAAGTCAGCTCGATGCCCATGGGGTCTCTGGAACATGAG
GGGCTGGTAAGCCTGAGGCCTGTGGGGTTGCAGGAACAGGAGGGGCCCATGAGCCTGGGG
CCTGTGGGGTCTGCAGGCCCAGTGGAGACCTCTAAGGGGTTGCTGGGGCAGGAGGGCCTG
GTGGAAATTGCCATGGACTCACCAGAGCAAGAGGGGCTGGTGGGTCCCATGGAGATCACC
ATGGGGTCTCTGGAGAAGGCAGGGCCTGTGAGCCCAGGATGTGTGAAGCTGGCAGGGCAG
GAGGGCCTGGTGGAGATGGTGCTATTGATGGAGCCAGGGGCGATGCGCTTCCTGCAGCTC
TACCATGAGGACCTTCTTGCGGGCCTGGGAGACGTCGCTCTCTTGCCACTTGAAGGACCG
GATATGACTGGCTTTCGGCTCTGTGGAGCCCAGGCTTCCTGCCAGGCGGCTGAGGAGTTT
CTGCGGAGCCTGCTGGGCAGCATTAGCTGCCATGTGTTGTGCCTGGAGCACCCGGGCAGC
GCCAGGTTTCTCCTGGGCCCAGAAGGGCAGCACCTTCTCCAGGGGCTGGAGGCTCAGTTC
CAGTGTGTCTTTGGGACAGAGCGCCTGGCCACAGCCACGTTGGACACAGGCCTTGAAGAG
GTGGACCCTACCGAGGCCCTCCCAGTGCTCCCTGGCAACGCCCACACCCTGTGGACCCCA
GACAGTACAGGTGGTGACCAGGAGGACGTGAGCCTGGAGGAGGTCCGAGAACTGCTGGCC
ACCCTGGAGGGCCTAGACCTAGACGGGGAGGACTGGCTGCCTCGGGAGCTGGAGGAGGAA
GGGCCTCAGGAGCAGCCAGAGGAGGAGGTGACCCCAGGGCATGAGGAGGAGGAGCCTGTG
GCCCCCAGCACTGTGGCACCCAGGTGGCTGGAGGAGGAGGCCGCTCTGCAGCTGGCCCTC
CACCGGTCACTGGAGCCTCAAGGTCAGGTGGCTGAGCAGGAGGAGGCTGCTGCCCTGCGG
CAAGCCCTAACCCTCTCCCTGCTGGAGCAGCCCCCGTTGGAGGCAGAAGAGCCCCCAGAT
GGGGGGACTGATGGCAAGGCCCAGCTGGTGGTGCACTCGGCCTTTGAGCAGGATGTGGAG
GAGCTGGACCGGGCGCTCAGGGCTGCCTTGGAGGTCCACGTCCAGGAGGAGACGGTGGGG
CCCTGGCGCCGCACACTGCCTGCAGAGCTGCGTGCTCGCCTGGAGCGGTGCCATGGTGTG
AGTGTTGCCCTGCGTGGTGACTGCACCATCCTCCGTGGCTTCGGGGCCCACCCTGCCCGT
GCTGCCCGCCACTTGGTGGCACTTCTGGCTGGCCCCTGGGATCAGAGTTTGGCCTTTCCC
TTGGCAGCTTCAGGCCCTACCTTGGCGGGGCAGACGCTGAAGGGGCCCTGGAACAACCTG
GAGCGTCTGGCAGAGAACACCGGGGAGTTCCAGGAGGTGGTGCGGGCCTTCTACGACACC
CTGGACGCTGCCCGCAGCAGCATCCGCGTCGTTCGTGTGGAGCGCGTGTCGCACCCGCTG
CTGCAGCAGCAGTATGAGCTGTACCGGGAGCGCCTGCTGCAGCGATGCGAGCGGCGCCCG
GTGGAGCAGGTGCTGTACCACGGCACGACGGCACCGGCAGTGCCTGACATCTGCGCCCAC
GGCTTCAACCGCAGCTTCTGCGGCCGCAACGCCACGGTCTACGGGAAGGGCGTGTATTTC
GCCAGGCGCGCCTCCCTGTCGGTGCAGGACCGCTACTCGCCCCCCAACGCCGATGGCCAT
AAGGCGGTGTTCGTGGCACGGGTGCTGACTGGCGACTACGGGCAGGGCCGCCGCGGTCTG
CGGGCGCCCCCTCTGCGGGGTCCTGGCCACGTGCTCCTGCGCTACGACAGCGCCGTGGAC
TGCATCTGCCAGCCCAGCATCTTCGTCATCTTCCACGACACCCAGGCGCTGCCCACCCAC
CTCATCACCTGCGAGCACGTGCCCCGCGCTTCCCCCGGCGACCCCTCTGGGCTCCCGGGC
CGCTCCCCAGACACTTAA
|
Protein Properties |
Number of Residues
| 1025 |
Molecular Weight
| 109997.35 |
Theoretical pI
| 4.968 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Poly [ADP-ribose] polymerase 10
MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT
|
External Links |
GenBank ID Protein
| 62897387 |
UniProtKB/Swiss-Prot ID
| Q53GL7 |
UniProtKB/Swiss-Prot Entry Name
| PAR10_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK222914 |
GeneCard ID
| PARP10 |
GenAtlas ID
| PARP10 |
HGNC ID
| HGNC:25895 |
References |
General References
| Not Available |