Showing Protein Aldo-keto reductase family 1 member C2 (CDBP00379)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 compounds
Identification
HMDB Protein ID CDBP00379
Secondary Accession Numbers Not Available
Name Aldo-keto reductase family 1 member C2
Description Not Available
Synonyms
  1. 3-alpha-HSD3
  2. Chlordecone reductase homolog HAKRD
  3. DD-2
  4. DD/BABP
  5. DD2
  6. Dihydrodiol dehydrogenase 2
  7. Dihydrodiol dehydrogenase/bile acid-binding protein
  8. Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
  9. Type III 3-alpha-hydroxysteroid dehydrogenase
Gene Name AKR1C2
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
GO Classification
Biological Process
daunorubicin metabolic process
digestion
doxorubicin metabolic process
cellular response to jasmonic acid stimulus
progesterone metabolic process
positive regulation of protein kinase B signaling cascade
response to prostaglandin stimulus
positive regulation of cell proliferation
prostaglandin metabolic process
Cellular Component
cytoplasm
Function
catalytic activity
oxidoreductase activity
Molecular Function
androsterone dehydrogenase (A-specific) activity
prostaglandin F receptor activity
alditol:NADP+ 1-oxidoreductase activity
bile acid binding
ketosteroid monooxygenase activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm (Potential)
Pathways
Gene Properties
Chromosome Location 10
Locus 10p15-p14
SNPs AKR1C2
Gene Sequence 
>972 bp
ATGGATTCGAAATACCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTCTAGAGGCCGTCAAATTG
GCAATAGAAGCCGGGTTCCACCATATTGATTCTGCACATGTTTACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGAGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGACTATGTTGACCTCTATCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACATGGGAGGCCATGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCACAGGCTGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCATCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA
Protein Properties
Number of Residues 323
Molecular Weight 15747.91
Theoretical pI 8.148
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Aldo-keto reductase family 1 member C2
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
GenBank ID Protein 4062863
UniProtKB/Swiss-Prot ID P52895
UniProtKB/Swiss-Prot Entry Name AK1C2_HUMAN
PDB IDs
GenBank Gene ID AB021654
GeneCard ID AKR1C2
GenAtlas ID AKR1C2
HGNC ID HGNC:385
References
General References Not Available