Identification |
HMDB Protein ID
| CDBP00075 |
Secondary Accession Numbers
| Not Available |
Name
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
Description
| Not Available |
Synonyms
|
- 15-PGDH
- Prostaglandin dehydrogenase 1
|
Gene Name
| HPGD |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in oxidoreductase activity |
Specific Function
| Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
|
GO Classification
|
Biological Process |
transforming growth factor beta receptor signaling pathway |
ductus arteriosus closure |
thrombin receptor signaling pathway |
negative regulation of cell cycle |
female pregnancy |
ovulation |
lipoxygenase pathway |
parturition |
prostaglandin metabolic process |
oxidation-reduction process |
Cellular Component |
cytosol |
cytoplasm |
nucleus |
Function |
binding |
catalytic activity |
oxidoreductase activity |
Molecular Function |
15-hydroxyprostaglandin dehydrogenase (NAD+) activity |
prostaglandin E receptor activity |
oxidoreductase activity |
protein homodimerization activity |
NAD+ binding |
nucleotide binding |
Process |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Transcriptional misregulation in cancer | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q34-q35 |
SNPs
| HPGD |
Gene Sequence
|
>801 bp
ATGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTCAGGGCATAGGCAGAGCC
TTTGCAGAGGCGCTGCTGCTTAAGGGCGCCAAGGTAGCGCTGGTGGATTGGAATCTTGAA
GCAGGTGTACAGTGTAAAGCTGCCCTGGATGAGCAGTTTGAACCTCAGAAGACTCTGTTC
ATCCAGTGCGATGTGGCTGACCAGCAACAACTGAGAGACACTTTTAGAAAAGTTGTAGAC
CACTTTGGAAGACTGGACATTTTGGTCAATAATGCTGGAGTGAATAATGAGAAAAACTGG
GAAAAAACTCTGCAAATTAATTTGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGGAT
TACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCA
GGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGA
TTCACACGCTCAGCAGCGTTGGCTGCTAATCTTATGAACAGTGGTGTGAGACTGAATGCC
ATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATG
GGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTG
GACCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGT
GCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCA
TTTCAAGCAAAAACCCAATGA
|
Protein Properties |
Number of Residues
| 266 |
Molecular Weight
| 28977.105 |
Theoretical pI
| 5.857 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>15-hydroxyprostaglandin dehydrogenase [NAD+]
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
|
External Links |
GenBank ID Protein
| 189054417 |
UniProtKB/Swiss-Prot ID
| P15428 |
UniProtKB/Swiss-Prot Entry Name
| PGDH_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK314624 |
GeneCard ID
| HPGD |
GenAtlas ID
| HPGD |
HGNC ID
| HGNC:5154 |
References |
General References
| Not Available |