Identification
HMDB Protein ID CDBP00075
Secondary Accession Numbers Not Available
Name 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Description Not Available
Synonyms
  1. 15-PGDH
  2. Prostaglandin dehydrogenase 1
Gene Name HPGD
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
GO Classification
Biological Process
transforming growth factor beta receptor signaling pathway
ductus arteriosus closure
thrombin receptor signaling pathway
negative regulation of cell cycle
female pregnancy
ovulation
lipoxygenase pathway
parturition
prostaglandin metabolic process
oxidation-reduction process
Cellular Component
cytosol
cytoplasm
nucleus
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
prostaglandin E receptor activity
oxidoreductase activity
protein homodimerization activity
NAD+ binding
nucleotide binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 4
Locus 4q34-q35
SNPs HPGD
Gene Sequence
>801 bp
ATGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTCAGGGCATAGGCAGAGCC
TTTGCAGAGGCGCTGCTGCTTAAGGGCGCCAAGGTAGCGCTGGTGGATTGGAATCTTGAA
GCAGGTGTACAGTGTAAAGCTGCCCTGGATGAGCAGTTTGAACCTCAGAAGACTCTGTTC
ATCCAGTGCGATGTGGCTGACCAGCAACAACTGAGAGACACTTTTAGAAAAGTTGTAGAC
CACTTTGGAAGACTGGACATTTTGGTCAATAATGCTGGAGTGAATAATGAGAAAAACTGG
GAAAAAACTCTGCAAATTAATTTGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGGAT
TACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCA
GGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGA
TTCACACGCTCAGCAGCGTTGGCTGCTAATCTTATGAACAGTGGTGTGAGACTGAATGCC
ATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATG
GGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTG
GACCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGT
GCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCA
TTTCAAGCAAAAACCCAATGA
Protein Properties
Number of Residues 266
Molecular Weight 28977.105
Theoretical pI 5.857
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>15-hydroxyprostaglandin dehydrogenase [NAD+]
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
GenBank ID Protein 189054417
UniProtKB/Swiss-Prot ID P15428
UniProtKB/Swiss-Prot Entry Name PGDH_HUMAN
PDB IDs
GenBank Gene ID AK314624
GeneCard ID HPGD
GenAtlas ID HPGD
HGNC ID HGNC:5154
References
General References Not Available