Identification |
HMDB Protein ID
| CDBP05119 |
Secondary Accession Numbers
| Not Available |
Name
| L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
Description
| Not Available |
Synonyms
|
- 4'-phosphopantetheinyl transferase
- AASD-PPT
- Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
- LYS5 ortholog
|
Gene Name
| AASDHPPT |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in magnesium ion binding |
Specific Function
| Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.
|
GO Classification
|
Biological Process |
macromolecule biosynthetic process |
pantothenate metabolic process |
Cellular Component |
cytosol |
Function |
magnesium ion binding |
phosphotransferase activity, for other substituted phosphate groups |
holo-[acyl-carrier-protein] synthase activity |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
Molecular Function |
magnesium ion binding |
holo-[acyl-carrier-protein] synthase activity |
Process |
macromolecule biosynthetic process |
metabolic process |
biosynthetic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 11 |
Locus
| 11q22 |
SNPs
| AASDHPPT |
Gene Sequence
|
>930 bp
ATGGTTTTCCCTGCCAAACGGTTCTGCTTGGTGCCATCCATGGAGGGCGTGCGCTGGGCC
TTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATT
CAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCC
ATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAAT
CATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAAT
CCATACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCT
GAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCA
ATTCCAGAATTCTTTCATATTATGAAAAGAAAGTTTACCAACAAAGAATGGGAAACAATC
AGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAATTGGGCACTTAAG
GAAAGCTTCATAAAAGCCATTGGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTT
GATCTATCTCCATTAAACTTGGATATAGGCCAAGTTTATAAAGAAACACGTTTATTCCTG
GATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGATGAGCACCATTTT
GTTGCAGTTGCTCTTAGGAAACCCGACGGATCTAGACATCAGGATGTTCCATCTCAGGAT
GATTCCAAACCAACCCAGAGGCAATTTACTATTCTCAACTTTAATGATTTAATGTCATCT
GCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGCTTCACAGAAGAA
ATTCCAATACGAAATGGTACAAAGTCATGA
|
Protein Properties |
Number of Residues
| 309 |
Molecular Weight
| 35775.64 |
Theoretical pI
| 6.805 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAA
MAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAA
EPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALK
ESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHF
VAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEE
IPIRNGTKS
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9NRN7 |
UniProtKB/Swiss-Prot Entry Name
| ADPPT_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF302110 |
GeneCard ID
| AASDHPPT |
GenAtlas ID
| AASDHPPT |
HGNC ID
| HGNC:14235 |
References |
General References
| Not Available |