| Identification |
|---|
| HMDB Protein ID
| CDBP00147 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- CI-23kD
- Complex I-23kD
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- TYKY subunit
|
| Gene Name
| NDUFS8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| mitochondrial electron transport, NADH to ubiquinone |
| response to oxidative stress |
| mitochondrial respiratory chain complex I assembly |
| Cellular Component |
| mitochondrial respiratory chain complex I |
| Component |
| membrane |
| cell part |
| Function |
| electron carrier activity |
| metal cluster binding |
| iron-sulfur cluster binding |
| 4 iron, 4 sulfur cluster binding |
| oxidoreductase activity |
| oxidoreductase activity, acting on nadh or nadph |
| binding |
| catalytic activity |
| Molecular Function |
| electron carrier activity |
| metal ion binding |
| 4 iron, 4 sulfur cluster binding |
| NADH dehydrogenase (ubiquinone) activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Mitochondrion (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidative phosphorylation | Not Available |  | | Alzheimer's disease | Not Available |  | | Parkinson's disease | Not Available |  | | Huntington's disease | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13 |
| SNPs
| NDUFS8 |
| Gene Sequence
|
>633 bp
ATGCGCTGCCTGACCACGCCTATGCTGCTGCGGGCCCTGGCCCAGGCTGCACGTGCAGGA
CCTCCTGGTGGCCGGAGCCTCCACAGCAGTGCAGTGGCAGCCACCTACAAGTATGTGAAC
ATGCAGGATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTG
TGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCC
ACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCG
CTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATC
TGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACC
ACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGT
CCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAG
CTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCC
GCCAACATCCAGGCTGACTACTTGTATCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 210 |
| Molecular Weight
| 23704.795 |
| Theoretical pI
| 6.342 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLL
WTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAI
CPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE
LLYNKEKLLNNGDKWEAEIAANIQADYLYR
|
| External Links |
|---|
| GenBank ID Protein
| 1935056 |
| UniProtKB/Swiss-Prot ID
| O00217 |
| UniProtKB/Swiss-Prot Entry Name
| NDUS8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U65579 |
| GeneCard ID
| NDUFS8 |
| GenAtlas ID
| NDUFS8 |
| HGNC ID
| HGNC:7715 |
| References |
|---|
| General References
| Not Available |