<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <id type="integer">148</id>
  <cancdbp-id>CDBP00147</cancdbp-id>
  <name>NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial</name>
  <uniprot-id>O00217</uniprot-id>
  <uniprot-name>NDUS8_HUMAN</uniprot-name>
  <enzyme type="boolean">true</enzyme>
  <transporter type="boolean">false</transporter>
  <protein-type>Enzyme</protein-type>
  <organism>Homo_sapiens</organism>
  <gene-name>NDUFS8</gene-name>
  <num-residues type="integer">210</num-residues>
  <molecular-weight type="decimal">23704.795</molecular-weight>
  <theoretical-pi type="decimal">6.342</theoretical-pi>
  <general-function>Involved in electron carrier activity</general-function>
  <specific-function>Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
</specific-function>
  <signal-regions type="array"/>
  <transmembrane-regions type="array"/>
  <pdb-ids></pdb-ids>
  <genbank-gene-id>U65579</genbank-gene-id>
  <genbank-protein-id>1935056</genbank-protein-id>
  <genecard-id>NDUFS8</genecard-id>
  <chromosome-location>11</chromosome-location>
  <locus>11q13</locus>
  <geneatlas-id>NDUFS8</geneatlas-id>
  <hgnc-id>HGNC:7715</hgnc-id>
  <export type="boolean">true</export>
  <comment nil="true"/>
  <kegg-id>hsa:4728</kegg-id>
  <meta-cyc-id></meta-cyc-id>
  <ncbi-sequence-ids>NP_002487.1:NM_002496.3</ncbi-sequence-ids>
  <tissue-specificity></tissue-specificity>
  <cofactor>4Fe-4S clusters</cofactor>
  <subunit>Mammalian complex I is composed of 45 different subunits
</subunit>
  <cellular-location nil="true"/>
  <ec-number nil="true"/>
  <created-at type="dateTime">2020-06-12T23:06:47Z</created-at>
  <updated-at type="dateTime">2020-07-28T02:24:55Z</updated-at>
  <description nil="true"/>
  <receptor type="integer">0</receptor>
  <metal-binding type="integer">1</metal-binding>
  <trans-factor type="integer">0</trans-factor>
</protein>

