| Identification |
|---|
| HMDB Protein ID
| CDBP01543 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD(P)H dehydrogenase [quinone] 1 |
| Description
| Not Available |
| Synonyms
|
- Azoreductase
- DT-diaphorase
- DTD
- Menadione reductase
- NAD(P)H:quinone oxidoreductase 1
- Phylloquinone reductase
- QR1
- Quinone reductase 1
|
| Gene Name
| NQO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| regulation of cellular amino acid metabolic process |
| response to oxidative stress |
| xenobiotic metabolic process |
| synaptic transmission, cholinergic |
| response to toxin |
| negative regulation of catalytic activity |
| positive regulation of neuron apoptotic process |
| nitric oxide biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| binding |
| catalytic activity |
| electron carrier activity |
| coenzyme binding |
| cofactor binding |
| oxidoreductase activity |
| Molecular Function |
| cytochrome-b5 reductase activity |
| NAD(P)H dehydrogenase (quinone) activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG |
|---|
| Vitamin K Metabolism |    | Not Available | | Ubiquinone and other terpenoid-quinone biosynthesis | Not Available |  | | Doxorubicin Metabolism Pathway |    | Not Available | | Phenytoin (Antiarrhythmic) Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q22.1 |
| SNPs
| NQO1 |
| Gene Sequence
|
>825 bp
ATGGTCGGCAGAAGAGCACTGATCGTACTGGCTCACTCAGAGAGGACCTCCTTCAACTAT
GCCATGAAGGAGGCTGCTGCAGCGGCTTTGAAGAAGAAAGGATGGGAGGTGGTGGAGTCG
GACCTCTATGCCATGAACTTCAATCCCATCATTTCCAGAAAGGACATCACAGGTAAACTG
AAGGACCCTGCGAACTTTCAGTATCCTGCCGAGTCTGTTCTGGCTTATAAAGAAGGCCAT
CTGAGCCCAGATATTGTGGCTGAACAAAAGAAGCTGGAAGCCGCAGACCTTGTGATATTC
CAGTTCCCCCTGCAGTGGTTTGGAGTCCCTGCCATTCTGAAAGGCTGGTTTGAGCGAGTG
TTCATAGGAGAGTTTGCTTACACTTACGCTGCCATGTATGACAAAGGACCCTTCCGGAGT
AAGAAGGCAGTGCTTTCCATCACCACTGGTGGCAGTGGCTCCATGTACTCTCTGCAAGGG
ATCCACGGGGACATGAATGTCATTCTCTGGCCAATTCAGAGTGGCATTCTGCATTTCTGT
GGCTTCCAAGTCTTAGAACCTCAACTGACATATAGCATTGGGCACACTCCAGCAGACGCC
CGAATTCAAATCCTGGAAGGATGGAAGAAACGCCTGGAGAATATTTGGGATGAGACACCA
CTGTATTTTGCTCCAAGCAGCCTCTTTGACCTAAACTTCCAGGCAGGATTCTTAATGAAA
AAAGAGGTACAGGATGAGGAGAAAAACAAGAAATTTGGCCTTTCTGTGGGCCATCACTTG
GGCAAGTCCATCCCAACTGACAACCAGATCAAAGCTAGAAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 274 |
| Molecular Weight
| 30867.405 |
| Theoretical pI
| 8.886 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD(P)H dehydrogenase [quinone] 1
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P15559 |
| UniProtKB/Swiss-Prot Entry Name
| NQO1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J03934 |
| GeneCard ID
| NQO1 |
| GenAtlas ID
| NQO1 |
| HGNC ID
| HGNC:2874 |
| References |
|---|
| General References
| Not Available |