Cannabis Compound Database: Showing Protein 4-trimethylaminobutyraldehyde dehydrogenase (CDBP00285)

Identification Biological properties Gene properties Protein properties External links References XML Show 18 compounds

Identification

HMDB Protein ID

CDBP00285

Secondary Accession Numbers

Not Available

Name

4-trimethylaminobutyraldehyde dehydrogenase

Description

Not Available

Synonyms

Aldehyde dehydrogenase E3 isozyme
Aldehyde dehydrogenase family 9 member A1
Gamma-aminobutyraldehyde dehydrogenase
R-aminobutyraldehyde dehydrogenase
TMABADH

Gene Name

ALDH9A1

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

GO Classification

Biological Process
hormone metabolic process
cellular aldehyde metabolic process
neurotransmitter biosynthetic process
liver development
kidney development
carnitine biosynthetic process
Cellular Component
cytosol
mitochondrion
plasma membrane
Function
catalytic activity
oxidoreductase activity
Molecular Function
1-pyrroline dehydrogenase activity
4-trimethylammoniobutyraldehyde dehydrogenase activity
amine binding
aminobutyraldehyde dehydrogenase activity
NAD binding
3-chloroallyl aldehyde dehydrogenase activity
Process
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
carnitine biosynthesis	Not Available	Not Available
Glycolysis / Gluconeogenesis	Not Available
Ascorbate and aldarate metabolism	Not Available
Carnitine Synthesis		Not Available

Gene Properties

Chromosome Location

Locus

1q23.1

SNPs

ALDH9A1

Gene Sequence

>1485 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCCGCGTG
GAGCCGGCGGACGCCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATA
GCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCT
GCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCT
GCCAGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGC
AAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTAT
GCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGT
TATACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTT
CAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAA
CCTTCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGT
GTACCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGT
CAGCATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATC
ATGGAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCA
CTCATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAAC
TTCCTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATT
CTTGATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCC
CTTCTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTT
GGGTTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATAT
GTACCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAAT
TGCAGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTA
TCATTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCA
GCTGGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCT
GGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATAT
AAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTG
AAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

Protein Properties

Number of Residues

494

Molecular Weight

56291.485

Theoretical pI

6.564

Pfam Domain Function

Aldedh (PF00171 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>4-trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

External Links

GenBank ID Protein

7248636

UniProtKB/Swiss-Prot ID

P49189

UniProtKB/Swiss-Prot Entry Name

AL9A1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF172093

GeneCard ID