Identification
HMDB Protein ID CDBP00200
Secondary Accession Numbers Not Available
Name Retinal dehydrogenase 2
Description Not Available
Synonyms
  1. Aldehyde dehydrogenase family 1 member A2
  2. RALDH 2
  3. RALDH(II)
  4. RalDH2
  5. Retinaldehyde-specific dehydrogenase type 2
Gene Name ALDH1A2
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
GO Classification
Biological Process
morphogenesis of embryonic epithelium
liver development
retinal metabolic process
negative regulation of cell proliferation
9-cis-retinoic acid biosynthetic process
neural crest cell development
anterior/posterior pattern specification
neural tube development
blood vessel development
neuron differentiation
cellular response to retinoic acid
pancreas development
determination of bilateral symmetry
pituitary gland development
embryonic camera-type eye development
positive regulation of gene expression
embryonic forelimb morphogenesis
proximal/distal pattern formation
face development
regulation of endothelial cell proliferation
embryonic digestive tract development
response to cytokine stimulus
heart morphogenesis
response to estradiol stimulus
hindbrain development
positive regulation of apoptotic process
response to vitamin A
retinoic acid receptor signaling pathway
kidney development
positive regulation of cell proliferation
ureter maturation
lung development
retinol metabolic process
vitamin A metabolic process
midgut development
retinoic acid metabolic process
Cellular Component
cytosol
cytoplasm
nucleus
Function
catalytic activity
oxidoreductase activity
Molecular Function
retinal dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity
retinal binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 15
Locus 15q21.3
SNPs ALDH1A2
Gene Sequence
>1557 bp
ATGACTTCCAGCAAGATAGAGATGCCCGGCGAGGTGAAGGCCGACCCCGCCGCCCTCATG
GCGTCGCTGCACCTCCTGCCGTCGCCCACGCCCAATCTCGAAATTAAGTACACCAAGATC
TTTATAAACAACGAGTGGCAGAACTCAGAGAGTGGGAGAGTGTTCCCTGTCTATAATCCA
GCCACAGGAGAACAGGTGTGTGAAGTTCAAGAAGCAGACAAGGCAGATATAGACAAAGCA
GTGCAGGCAGCCCGCCTGGCTTTCTCTCTTGGTTCAGTGTGGAGAAGGATGGATGCTTCA
GAAAGGGGACGTCTGTTGGATAAGCTTGCAGACTTGGTGGAACGGGACAGGGCAGTTCTT
GCAACCATGGAATCCCTAAATGGTGGCAAACCATTCCTGCAAGCTTTTTATGTGGATTTG
CAGGGCGTCATCAAAACCTTTCGATATTACGCAGGCTGGGCTGATAAAATTCATGGGATG
ACCATTCCTGTAGATGGAGACTATTTTACCTTTACAAGACATGAACCCATTGGAGTGTGT
GGACAGATCATCCCATGGAACTTCCCCCTGCTGATGTTTGCCTGGAAAATAGCTCCAGCT
TTGTGCTGTGGCAATACAGTAGTTATTAAGCCAGCAGAGCAAACACCACTCAGTGCACTC
TACATGGGAGCCCTCATCAAGGAGGCTGGCTTTCCTCCCGGGGTCATCAATATTTTGCCA
GGATATGGGCCAACGGCTGGGGCAGCAATAGCTTCTCACATTGGCATAGACAAGATTGCA
TTCACAGGGTCTACTGAGGTTGGAAAGCTTATCCAAGAAGCAGCTGGAAGAAGTAATTTG
AAGAGAGTAACTCTGGAACTTGGAGGCAAAAGTCCTAATATTATTTTTGCTGATGCTGAC
TTGGACTATGCTGTGGAGCAGGCCCACCAGGGTGTGTTCTTCAATCAAGGTCAGTGCTGC
ACTGCAGGCTCTCGCATCTTCGTGGAGGAGTCCATCTATGAGGAGTTTGTGAGAAGAAGC
GTGGAGCGGGCCAAGAGGCGCATAGTGGGGAGTCCCTTTGACCCCACCACTGAGCAGGGT
CCCCAGATTGATAAGAAACAGTACAACAAGATCTTGGAACTCATCCAGAGTGGTGTGGCT
GAGGGCGCCAAGCTGGAATGTGGAGGCAAAGGACTGGGCCGAAAGGGGTTTTTCATTGAG
CCCACAGTGTTTTCCAACGTCACTGATGATATGCGGATTGCCAAGGAGGAGATCTTTGGC
CCTGTTCAGGAAATTTTGAGATTTAAGACGATGGATGAAGTTATCGAAAGAGCCAATAAC
TCAGACTTTGGACTCGTAGCAGCTGTCTTTACTAATGACATCAACAAGGCCCTCACAGTG
TCTTCTGCAATGCAAGCTGGGACTGTTTGGATCAATTGTTACAATGCCTTAAATGCCCAG
AGCCCCTTTGGGGGATTCAAGATGTCTGGAAATGGGAGAGAAATGGGAGAATTTGGCTTG
CGGGAGTACTCAGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAA
Protein Properties
Number of Residues 518
Molecular Weight 54672.24
Theoretical pI 6.589
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Retinal dehydrogenase 2
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
GenBank ID Protein 3970842
UniProtKB/Swiss-Prot ID O94788
UniProtKB/Swiss-Prot Entry Name AL1A2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB015226
GeneCard ID ALDH1A2
GenAtlas ID ALDH1A2
HGNC ID HGNC:15472
References
General References Not Available