Cannabis Compound Database: Showing Protein Estradiol 17-beta-dehydrogenase 8 (CDBP00439)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00439

Secondary Accession Numbers

Not Available

Name

Estradiol 17-beta-dehydrogenase 8

Description

Not Available

Synonyms

17-beta-HSD 8
17-beta-hydroxysteroid dehydrogenase 8
3-oxoacyl-[acyl-carrier-protein] reductase
Ke-6
Protein Ke6
Really interesting new gene 2 protein
Testosterone 17-beta-dehydrogenase 8

Gene Name

HSD17B8

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

GO Classification

Biological Process
androgen metabolic process
fatty acid biosynthetic process
estrogen biosynthetic process
Cellular Component
mitochondrial matrix
plasma membrane
mitochondrial envelope
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
testosterone dehydrogenase (NAD+) activity
estradiol 17-beta-dehydrogenase activity
testosterone 17-beta-dehydrogenase (NAD+) activity
3-hydroxyacyl-CoA dehydrogenase activity
nucleotide binding
Process
metabolic process
oxidation reduction

Cellular Location

Mitochondrion matrix

Pathways

Name	SMPDB/Pathwhiz	KEGG
estrogen biosynthesis	Not Available	Not Available
Steroid hormone biosynthesis	Not Available

Gene Properties

Chromosome Location

Locus

6p21.3

SNPs

HSD17B8

Gene Sequence

>786 bp
ATGGCGTCTCAGCTCCAGAACCGACTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGGG
AGCGGCATCGGCCGAGCGGTCAGTGTACGCCTGGCCGGAGAGGGGGCCACCGTAGCTGCC
TGCGACCTGGACCGGGCAGCGGCACAGGAGACGGTGCGGCTGCTGGGCGGGCCAGGGAGC
AAGGAGGGGCCGCCCCGAGGGAACCATGCTGCCTTCCAGGCTGACGTGTCTGAGGCCAGG
GCCGCCAGGTGCCTGCTGGAACAAGTGCAGGCCTGCTTTTCTCGCCCACCATCTGTCGTT
GTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACATGTCTGAGGATGACTGG
GACAAAGTCATAGCTGTCAACCTCAAGGGCACCTTCCTAGTCACTCAGGCTGCAGCACAA
GCCCTGGTGTCCAATGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATCGTAGGAAAG
GTGGGGAACGTGGGGCAGACAAACTATGCAGCATCCAAGGCTGGAGTGATTGGGCTGACC
CAGACCGCAGCCCGGGAGCTTGGACGACATGGGATCCGCTGTAACTCTGTCCTCCCAGGG
TTCATTGCAACACCCATGACACAGAAAGTGCCACAGAAAGTGGTGGACAAGATTACTGAA
ATGATCCCGATGGGACACTTGGGGGACCCTGAGGATGTGGCAGATGTGGTCGCATTCTTG
GCATCTGAAGATAGTGGATACATCACAGGGACCTCAGTGGAAGTCACTGGAGGTCTTTTC
ATGTAG

Protein Properties

Number of Residues

261

Molecular Weight

26973.56

Theoretical pI

6.533

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Estradiol 17-beta-dehydrogenase 8
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW
DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT
QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL
ASEDSGYITGTSVEVTGGLFM

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q92506

UniProtKB/Swiss-Prot Entry Name

DHB8_HUMAN

PDB IDs