Cannabis Compound Database: Showing Protein Kynureninase (CDBP00319)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00319

Secondary Accession Numbers

Not Available

Name

Kynureninase

Description

Not Available

Synonyms

L-kynurenine hydrolase
SubName: Kynureninase (L-kynurenine hydrolase), isoform CRA_a

Gene Name

KYNU

Protein Type

Enzyme

Biological Properties

General Function

Involved in metabolic process

Specific Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

GO Classification

Biological Process
NAD biosynthetic process
quinolinate biosynthetic process
tryptophan catabolic process
anthranilate metabolic process
response to vitamin B6
tryptophan catabolic process to acetyl-CoA
tryptophan catabolic process to kynurenine
response to interferon-gamma
L-kynurenine catabolic process
Cellular Component
cytosol
mitochondrion
nucleus
Component
cytoplasm
cell part
intracellular part
Function
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid carbon-carbon bonds
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
kynureninase activity
cofactor binding
pyridoxal phosphate binding
Molecular Function
kynureninase activity
pyridoxal phosphate binding
protein homodimerization activity
Process
nad biosynthetic process
indolalkylamine metabolic process
tryptophan metabolic process
tryptophan catabolic process
cellular metabolic process
cellular amino acid derivative metabolic process
cofactor metabolic process
cellular biogenic amine metabolic process
coenzyme metabolic process
cellular amino acid and derivative metabolic process
metabolic process
coenzyme biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process

Cellular Location

Cytoplasmic
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
NAD(+) biosynthesis	Not Available	Not Available
L-kynurenine degradation	Not Available	Not Available
Tryptophan Metabolism

Gene Properties

Chromosome Location

Locus

2q22.2

SNPs

KYNU

Gene Sequence

>1398 bp
ATGGAGCCTTCATCTCTTGAGCTGCCGGCTGACACAGTGCAGCGCATTGCGGCTGAACTC
AAATGCCACCCAACGGATGAGAGGGTGGCTCTCCACCTAGATGAGGAAGATAAGCTGAGG
CACTTCAGGGAGTGCTTTTATATTCCCAAAATACAGGATCTGCCTCCAGTTGATTTATCA
TTAGTGAATAAAGATGAAAATGCCATCTATTTCTTGGGAAATTCTCTTGGCCTTCAACCA
AAAATGGTTAAAACATATCTTGAAGAAGAACTAGATAAGTGGGCCAAAATAGCAGCCTAT
GGTCATGAAGTGGGGAAGCGTCCTTGGATTACAGGAGATGAGAGTATTGTAGGCCTTATG
AAGGACATTGTAGGAGCCAATGAGAAAGAAATAGCCCTAATGAATGCTTTGACTGTAAAT
TTACATCTTCTAATGTTATCATTTTTTAAGCCTACGCCAAAACGATATAAAATTCTTCTA
GAAGCCAAAGCCTTCCCTTCTGATCATTATGCTATTGAGTCACAACTACAACTTCACGGA
CTTAACATTGAAGAAAGTATGCGGATGATAAAGCCAAGAGAGGGGGAAGAAACCTTAAGA
ATAGAGGATATCCTTGAAGTAATTGAGAAGGAAGGAGACTCAATTGCAGTGATCCTGTTC
AGTGGGGTGCATTTTTACACTGGACAGCACTTTAATATTCCTGCCATCACAAAAGCTGGA
CAAGCGAAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTC
TACTTACATGACTGGGGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCA
GGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAACCT
GCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTG
CAGTTAATCCCTGGGGTCTGTGGATTCCGAATTTCAAATCCTCCCATTTTGTTGGTCTGT
TCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAAAA
TCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAA
GCAGCAACCAAGAAACCAGTTGTGAACATAATTACTCCGTCTCATGTAGAGGAGCGGGGG
TGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAAAA
AGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTC
TATAATTCTTTCCATGATGTTTATAAATTTACCAATCTGCTCACTTCTATACTTGACTCT
GCAGAAACAAAAAATTAG

Protein Properties

Number of Residues

465

Molecular Weight

34634.47

Theoretical pI

5.845

Pfam Domain Function

Aminotran_5 (PF00266 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Kynureninase
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

External Links

GenBank ID Protein

12654129

UniProtKB/Swiss-Prot ID

Q16719

UniProtKB/Swiss-Prot Entry Name

KYNU_HUMAN

PDB IDs