| Identification |
|---|
| HMDB Protein ID
| CDBP04081 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mono [ADP-ribose] polymerase PARP16 |
| Description
| Not Available |
| Synonyms
|
- PARP-16
- ADP-ribosyltransferase diphtheria toxin-like 15
- Poly [ADP-ribose] polymerase 16
- ARTD15
|
| Gene Name
| PARP16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.
|
| GO Classification
|
| Biological Process |
| response to unfolded protein |
| Cellular Component |
| endoplasmic reticulum membrane |
| nuclear membrane |
| integral to membrane |
| Function |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| catalytic activity |
| Molecular Function |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
| NAD+ ADP-ribosyltransferase activity |
|
| Cellular Location
|
- Membrane
- Single-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q22.31 |
| SNPs
| PARP16 |
| Gene Sequence
|
>969 bp
ATGCAGCCCTCAGGCTGGGCGGCCGCCAGGGAGGCGGCGGGCCGCGACATGCTGGCCGCC
GACCTCCGGTGCAGCCTCTTCGCCTCGGCCCTGCAGAGCTACAAGCGCGACTCGGTGCTG
CGGCCCTTCCCCGCGTCCTACGCCCGCGGCGACTGTAAGGACTTTGAAGCCCTGCTTGCA
GATGCCAGCAAGTTACCTAACCTGAAAGAACTTCTCCAGTCCTCCGGAGACAACCACAAA
CGGGCCTGGGACCTGGTGAGCTGGATTTTATCCTCAAAGGTCCTGACAATCCACAGTGCA
GGGAAGGCAGAGTTTGAAAAGATCCAAAAGCTGACTGGGGCTCCTCACACGCCTGTTCCT
GCACCGGACTTCCTGTTTGAAATTGAGTACTTTGACCCAGCCAACGCCAAATTTTATGAG
ACCAAAGGAGAACGAGACCTAATCTATGCATTTCATGGTAGCCGCCTAGAAAACTTCCAT
TCCATTATCCACAATGGCCTGCACTGCCATCTGAACAAGACATCCTTGTTCGGAGAGGGG
ACCTACCTCACCAGTGACTTAAGCCTGGCCCTCATATACAGCCCCCATGGCCATGGGTGG
CAGCACAGCCTCCTCGGCCCCATCCTTAGCTGTGTGGCCGTGTGTGAGGTCATTGACCAT
CCGGACGTCAAGTGCCAAACCAAGAAGAAGGATTCCAAGGAGATAGATCGCAGACGAGCG
AGAATCAAACATAGTGAAGGGGGAGACATCCCTCCCAAGTACTTCGTGGTCACCAATAAC
CAGCTGCTGCGAGTGAAGTACCTCCTGGTGTATTCACAGAAGCCACCCAAGAGGGCTCCG
AGCCAGCTCTCCTGGTTTTCCAGCCATTGGTTTACCGTCATGATATCCCTGTATCTGCTG
CTGCTGCTCATAGTGAGTGTCATCAACTCCTCTGCTTTCCAACACTTTTGGAATCGTGCG
AAAAGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 322 |
| Molecular Weight
| 36469.41 |
| Theoretical pI
| 9.049 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 16
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLA
DASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVP
APDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEG
TYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRA
RIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLL
LLLIVSVINSSAFQHFWNRAKR
|
| External Links |
|---|
| GenBank ID Protein
| 21411003 |
| UniProtKB/Swiss-Prot ID
| Q8N5Y8 |
| UniProtKB/Swiss-Prot Entry Name
| PAR16_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC031074 |
| GeneCard ID
| PARP16 |
| GenAtlas ID
| PARP16 |
| HGNC ID
| HGNC:26040 |
| References |
|---|
| General References
| Not Available |