Cannabis Compound Database: Showing Protein Dihydrolipoyl dehydrogenase, mitochondrial (CDBP00052)

Identification Biological properties Gene properties Protein properties External links References XML Show 11 compounds

Identification

HMDB Protein ID

CDBP00052

Secondary Accession Numbers

Not Available

Name

Dihydrolipoyl dehydrogenase, mitochondrial

Description

Not Available

Synonyms

Dihydrolipoamide dehydrogenase
Glycine cleavage system L protein

Gene Name

DLD

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.

GO Classification

Biological Process
gastrulation
lipoate metabolic process
mitochondrial electron transport, NADH to ubiquinone
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of membrane potential
sperm capacitation
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
pyruvate metabolic process
2-oxoglutarate metabolic process
lysine catabolic process
tricarboxylic acid cycle
proteolysis
aging
acetyl-CoA biosynthetic process from pyruvate
cell redox homeostasis
dihydrolipoamide metabolic process
Cellular Component
nucleus
flagellum
acrosomal matrix
oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex
mitochondrial matrix
Component
cell part
intracellular part
cytoplasm
Function
dihydrolipoyl dehydrogenase activity
fad or fadh2 binding
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on nadh or nadph
oxidoreductase activity, acting on a sulfur group of donors, nad or nadp as acceptor
Molecular Function
NAD binding
flavin adenine dinucleotide binding
dihydrolipoyl dehydrogenase activity
lipoamide binding
Process
metabolic process
cellular process
oxidation reduction
cellular homeostasis
cell redox homeostasis

Cellular Location

Mitochondrion matrix

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycolysis / Gluconeogenesis	Not Available
Citrate cycle (TCA cycle)	Not Available
Glycine, serine and threonine metabolism	Not Available
Citric Acid Cycle
Congenital lactic acidosis		Not Available

Gene Properties

Chromosome Location

Locus

7q31-q32

SNPs

DLD

Gene Sequence

>1530 bp
ATGCAGAGCTGGAGTCGTGTGTACTGCTCCTTGGCCAAGAGAGGCCATTTCAATCGAATA
TCTCATGGCCTACAGGGACTTTCTGCAGTGCCTCTGAGAACTTACGCAGATCAGCCGATT
GATGCTGATGTAACAGTTATAGGTTCTGGTCCTGGAGGATATGTTGCTGCTATTAAAGCT
GCCCAGTTAGGCTTCAAGACAGTCTGCATTGAGAAAAATGAAACACTTGGTGGAACATGC
TTGAATGTTGGTTGTATTCCTTCTAAGGCTTTATTGAACAACTCTCATTATTACCATATG
GCCCATGGAAAAGATTTTGCATCTAGAGGAATTGAAATGTCCGAAGTTCGCTTGAATTTA
GACAAGATGATGGAGCAGAAGAGTACTGCAGTAAAAGCTTTAACAGGTGGAATTGCCCAC
TTATTCAAACAGAATAAGGTTGTTCATGTCAATGGATATGGAAAGATAACTGGCAAAAAT
CAAGTCACTGCTACGAAAGCTGATGGCGGCACTCAGGTTATTGATACAAAGAACATTCTT
ATAGCCACGGGTTCAGAAGTTACTCCTTTTCCTGGAATCACGATAGATGAAGATACAATA
GTGTCATCTACAGGTGCTTTATCTTTAAAAAAAGTTCCAGAAAAGATGGTTGTTATTGGT
GCAGGAGTAATAGGTGTAGAATTGGGTTCAGTTTGGCAAAGACTTGGTGCAGATGTGACA
GCAGTTGAATTTTTAGGTCATGTAGGTGGAGTTGGAATTGATATGGAGATATCTAAAAAC
TTTCAACGCATCCTTCAAAAACAGGGGTTTAAATTTAAATTGAATACAAAGGTTACTGGT
GCTACCAAGAAGTCAGATGGAAAAATTGATGTTTCTATTGAAGCTGCTTCTGGTGGTAAA
GCTGAAGTTATCACTTGTGATGTACTCTTGGTTTGCATTGGCCGACGACCCTTTACTAAG
AATTTGGGACTAGAAGAGCTGGGAATTGAACTAGATCCCAGAGGTAGAATTCCAGTCAAT
ACCAGATTTCAAACTAAAATTCCAAATATCTATGCCATTGGTGATGTAGTTGCTGGTCCA
ATGCTGGCTCACAAAGCAGAGGATGAAGGCATTATCTGTGTTGAAGGAATGGCTGGTGGT
GCTGTGCACATTGACTACAATTGTGTGCCATCAGTGATTTACACACACCCTGAAGTTGCT
TGGGTTGGCAAATCAGAAGAGCAGTTGAAAGAAGAGGGTATTGAGTACAAAGTTGGGAAA
TTCCCATTTGCTGCTAACAGCAGAGCTAAGACAAATGCTGACACAGATGGCATGGTGAAG
ATCCTTGGGCAGAAATCGACAGACAGAGTACTGGGAGCACATATTCTTGGACCAGGTGCT
GGAGAAATGGTAAATGAAGCTGCTCTTGCTTTGGAATATGGAGCATCCTGTGAAGATATA
GCTAGAGTCTGTCATGCACATCCGACCTTATCAGAAGCTTTTAGAGAAGCAAATCTTGCT
GCGTCATTTGGCAAATCAATCAACTTTTGA

Protein Properties

Number of Residues

509

Molecular Weight

54176.91

Theoretical pI

7.855

Pfam Domain Function

Pyr_redox (PF00070 )
Pyr_redox_2 (PF07992 )
Pyr_redox_dim (PF02852 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dihydrolipoyl dehydrogenase, mitochondrial
MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
ARVCHAHPTLSEAFREANLAASFGKSINF

External Links

GenBank ID Protein

91199540

UniProtKB/Swiss-Prot ID

P09622

UniProtKB/Swiss-Prot Entry Name

DLDH_HUMAN

PDB IDs