| Identification |
|---|
| HMDB Protein ID
| CDBP04078 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly [ADP-ribose] polymerase 12 |
| Description
| Not Available |
| Synonyms
|
- PARP-12
- Zinc finger CCCH domain-containing protein 1
- ADP-ribosyltransferase diphtheria toxin-like 12
- ARTD12
|
| Gene Name
| PARP12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Cellular Component |
| nucleus |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| nucleic acid binding |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| NAD+ ADP-ribosyltransferase activity |
| zinc ion binding |
| nucleic acid binding |
| metal ion binding |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q34 |
| SNPs
| PARP12 |
| Gene Sequence
|
>2106 bp
ATGGCCCAGGCCGGCGTCGTCGGTGAGGTCACCCAGGTGCTGTGCGCGGCCGGGGGCGCC
CTGGAGTTGCCCGAGCTGCGGCGCCGCTTGCGGATGGGCTTGAGCGCCGACGCGCTGGAG
CGGCTGCTGCGGCAGCGTGGGCGCTTCGTGGTGGCGGTGCGGGCGGGCGGCGCAGCCGCG
GCCCCGGAGCGCGTGGTGCTGGCCGCCTCGCCGCTGCGCCTGTGTCGCGCGCACCAGGGC
TCCAAGCCGGGCTGCGTGGGGCTCTGCGCGCAGCTCCACCTCTGCAGGTTCATGGTCTAC
GGCGCCTGCAAGTTCCTGAGAGCCGGGAAGAACTGTAGGAATAGTCACAGCTTGACAACC
GAACACAACCTGAGTGTGCTGAGAACTCATGGCGTTGACCACCTGAGCTATAATGAGCTA
TGCCAACTCTTGTTTCAGAACGACCCCTGGCTTTTGCCAGAAATTTGCCAACATTACAAC
AAAGGAGATGGACCCCACGGCTCTTGTGCCTTTCAAAAGCAGTGCATCAAGCTCCATATC
TGCCAGTATTTTTTACAGGGGGAATGCAAGTTTGGCACTAGCTGTAAGAGATCCCATGAT
TTCTCTAATTCTGAGAATCTGGAAAAATTGGAGAAGTTGGGTATGAGCTCAGACCTGGTG
AGCAGGCTGCCTACCATTTATAGAAATGCACATGACATCAAGAATAAGAGCTCTGCCCCC
AGCAGAGTGCCTCCTCTTTTTGTCCCACAGGGGACTTCTGAAAGAAAAGACAGTTCAGGT
TCTGTGTCCCCAAACACTCTTAGCCAGGAGGAGGGTGATCAGATCTGTTTGTACCATATC
CGGAAAAGTTGTAGCTTTCAAGATAAGTGCCATAGAGTTCATTTCCATTTGCCGTATCGA
TGGCAATTCTTGGATAGAGGCAAATGGGAGGATTTGGACAACATGGAACTTATTGAAGAG
GCATATTGCAATCCCAAAATAGAAAGGATCCTGTGCTCTGAGTCAGCCAGTACCTTTCAC
TCTCATTGTCTGAACTTTAACGCCATGACTTACGGTGCTACCCAGGCTCGCCGCCTCTCC
ACGGCCTCCTCTGTCACCAAACCTCCACACTTCATCCTCACCACTGACTGGATTTGGTAC
TGGAGTGATGAGTTTGGTTCTTGGCAGGAATATGGAAGACAGGGCACGGTGCACCCTGTG
ACCACTGTCAGCAGTAGCGACGTGGAGAAGGCCTACCTGGCCTACTGTACACCGGGGTCT
GACGGCCAGGCAGCCACCTTGAAGTTCCAGGCCGGAAAGCACAACTACGAGTTAGATTTC
AAAGCCTTCGTTCAGAAAAACCTGGTCTATGGCACAACTAAAAAGGTTTGCCGCAGACCC
AAATACGTGTCTCCCCAGGATGTGACGACCATGCAAACCTGCAATACCAAGTTTCCAGGC
CCGAAGAGCATCCCAGACTATTGGGACTCCTCTGCCCTGCCAGACCCAGGCTTTCAGAAG
ATCACCCTTAGTTCTTCCTCGGAAGAGTATCAGAAGGTCTGGAACCTCTTTAACCGCACG
CTGCCTTTCTACTTTGTTCAGAAGATTGAGCGAGTACAGAACCTGGCCCTCTGGGAAGTC
TACCAGTGGCAAAAAGGACAGATGCAGAAGCAGAATGGAGGGAAGGCCGTGGACGAGCGG
CAGCTGTTCCACGGCACCAGCGCCATTTTTGTGGACGCCATCTGCCAGCAGAACTTTGAC
TGGCGGGTCTGTGGTGTTCATGGCACTTCCTACGGCAAGGGGAGCTACTTTGCCCGAGAT
GCTGCATATTCCCACCACTACAGCAAATCCGACACGCAGACCCACACGATGTTCCTGGCC
CGGGTGCTGGTGGGCGAGTTCGTCAGGGGCAATGCGTCCTTTGTCCGTCCGCCGGCCAAG
GAGGGCTGGAGCAACGCCTTCTATGATAGCTGCGTGAACAGTGTGTCCGACCCCTCCATC
TTTGTGATCTTTGAGAAACACCAGGTCTACCCAGAGTATGTCATCCAGTACACCACCTCC
TCCAAGCCCTCGGTCACACCCTCCATCCTGCTGGCCTTGGGCTCCCTGTTCAGCAGCCGA
CAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 701 |
| Molecular Weight
| 79063.08 |
| Theoretical pI
| 8.521 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 12
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
|
| External Links |
|---|
| GenBank ID Protein
| 12232413 |
| UniProtKB/Swiss-Prot ID
| Q9H0J9 |
| UniProtKB/Swiss-Prot Entry Name
| PAR12_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_022750.2 |
| GeneCard ID
| PARP12 |
| GenAtlas ID
| PARP12 |
| HGNC ID
| HGNC:21919 |
| References |
|---|
| General References
| Not Available |