Identification
HMDB Protein ID CDBP00867
Secondary Accession Numbers Not Available
Name Poly [ADP-ribose] polymerase 4
Description Not Available
Synonyms
  1. 193 kDa vault protein
  2. PARP-4
  3. PARP-related/IalphaI-related H5/proline-rich
  4. PH5P
  5. VPARP
  6. Vault poly(ADP-ribose) polymerase
  7. ADP-ribosyltransferase diphtheria toxin-like 4
  8. ARTD4
Gene Name PARP4
Protein Type Enzyme
Biological Properties
General Function Involved in NAD+ ADP-ribosyltransferase activity
Specific Function Not Available
GO Classification
Biological Process
DNA repair
inflammatory response
response to drug
protein ADP-ribosylation
transport
cell death
Cellular Component
ribonucleoprotein complex
cytoplasm
nucleus
spindle microtubule
Component
cell part
intracellular
Function
catalytic activity
transferase activity
nad+ adp-ribosyltransferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
NAD+ ADP-ribosyltransferase activity
enzyme binding
DNA binding
Process
protein modification process
metabolic process
macromolecule metabolic process
protein amino acid adp-ribosylation
post-translational protein modification
macromolecule modification
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
  5. spindle
Pathways
Gene Properties
Chromosome Location 13
Locus 13q11
SNPs PARP4
Gene Sequence
>5175 bp
ATGGTGATGGGAATCTTTGCAAATTGTATCTTCTGTTTGAAAGTGAAGTACTTACCTCAG
CAGCAGAAGAAAAAGCTACAAACTGACATTAAGGAAAATGGCGGAAAGTTTTCCTTTTCG
TTAAATCCTCAGTGCACACATATAATCTTAGATAATGCTGATGTTCTGAGTCAGTACCAA
CTGAATTCTATCCAAAAGAACCACGTTCATATTGCAAACCCAGATTTTATATGGAAATCT
ATCAGAGAAAAGAGACTCTTGGATGTAAAGAATTATGATCCTTATAAGCCCCTGGACATC
ACACCACCTCCTGATCAGAAGGCGAGCAGTTCTGAAGTGAAAACAGAAGGTCTATGCCCG
GACAGTGCCACAGAGGAGGAAGACACTGTGGAACTCACTGAGTTTGGTATGCAGAATGTT
GAAATTCCTCATCTTCCTCAAGATTTTGAAGTTGCAAAATATAACACCTTGGAGAAAGTG
GGAATGGAGGGAGGCCAGGAAGCTGTGGTGGTGGAGCTTCAGTGTTCGCGGGACTCCAGG
GACTGTCCTTTCCTGATATCCTCACACTTCCTCCTGGATGATGGCATGGAGACTAGAAGA
CAGTTTGCTATAAAGAAAACCTCTGAAGATGCAAGTGAATACTTTGAAAATTACATTGAA
GAACTGAAGAAACAAGGATTTCTACTAAGAGAACATTTCACACCTGAAGCAACCCAATTA
GCATCTGAACAATTGCAAGCATTGCTTTTGGAGGAAGTCATGAATTCAAGCACTCTGAGC
CAAGAGGTGAGCGATTTAGTAGAGATGATTTGGGCAGAGGCCCTGGGCCACCTGGAACAC
ATGCTTCTCAAGCCAGTGAACAGGATTAGCCTCAACGATGTGAGCAAGGCAGAGGGGATT
CTCCTTCTAGTAAAGGCAGCACTGAAAAATGGAGAAACAGCAGAGCAATTGCAAAAGATG
ATGACAGAGTTTTACAGACTGATACCTCACAAAGGCACAATGCCCAAAGAAGTGAACCTG
GGACTATTGGCTAAGAAAGCAGACCTCTGCCAGCTAATAAGAGACATGGTTAATGTCTGT
GAAACTAATTTGTCCAAACCCAACCCACCATCCCTGGCCAAATACCGAGCTTTGAGGTGC
AAAATTGAGCATGTTGAACAGAATACTGAAGAATTTCTCAGGGTTAGAAAAGAGGTTTTG
CAGAATCATCACAGTAAGAGCCCAGTGGATGTCTTGCAGATATTTAGAGTTGGCAGAGTG
AATGAAACCACAGAGTTTTTGAGCAAACTTGGTAATGTGAGGCCCTTGTTGCATGGTTCT
CCTGTACAAAACATCGTGGGAATCTTGTGTCGAGGGTTGCTTTTACCCAAAGTAGTGGAA
GATCGTGGTGTGCAAAGAACAGACGTCGGAAACCTTGGAAGTGGGATTTATTTCAGTGAT
TCGCTCAGTACAAGTATCAAGTACTCACACCCGGGAGAGACAGATGGCACCAGACTCCTG
CTCATTTGTGACGTAGCCCTCGGAAAGTGTATGGACTTACATGAGAAGGACTTTTCCTTA
ACTGAAGCACCACCAGGCTACGACAGTGTGCATGGAGTTTCACAAACAGCCTCTGTCACC
ACAGACTTTGAGGATGATGAATTTGTTGTCTATAAAACCAATCAGGTTAAAATGAAATAT
ATTATTAAATTTTCCATGCCTGGAGATCAGATAAAGGACTTTCATCCTAGTGATCATACT
GAATTAGAGGAATACAGACCTGAGTTTTCAAATTTTTCAAAGGTTGAAGATTACCAGTTA
CCAGATGCCAAAACTTCCAGCAGCACCAAGGCCGGCCTCCAGGATGCTTCTGGGAACTTG
GTTCCTCTGGAGGATGTCCACATCAAAGGGAGAATCATAGACACTGTAGCCCAGGTCATT
GTTTTTCAGACATACACAAATAAAAGTCACGTGCCCATTGAGGCAAAATATATCTTTCCT
TTGGATGACAAGGCCGCTGTGTGTGGCTTCGAAGCCTTCATCAATGGGAAGCACATAGTT
GGAGAGATTAAAGAGAAGGAAGAAGCCCAGCAAGAGTACCTAGAAGCCGTGACCCAGGGC
CATGGCGCTTACCTGATGAGTCAGGATGCTCCGGACGTTTTTACTGTAAGTGTTGGAAAC
TTACCCCCTAAGGCTAAGGTTCTTATAAAAATTACCTACATCACAGAACTCAGCATCCTG
GGCACTGTTGGTGTCTTTTTCATGCCCGCCACCGTAGCACCCTGGCAACAGGACAAGGCT
TTGAATGAAAACCTTCAGGATACAGTAGAGAAGATTTGTATAAAAGAAATAGGAACAAAG
CAAAGCTTCTCTTTGACTATGTCTATTGAGATGCCGTACGTGATTGAATTCATTTTCAGT
GATACTCATGAACTGAAACAAAAGCGCACAGACTGCAAAGCTGTCATTAGCACCATGGAA
GGCAGCTCCTTAGACAGCAGTGGATTTTCTCTCCACATCGGTTTGTCTGCTGCCTATCTC
CCAAGAATGTGGGTTGAAAAACATCCAGAAAAAGAAAGCGAGGCTTGCATGCTTGTCTTT
CAACCCGATCTCGATGTCGACCTCCCTGACCTAGCCAATGAGAGCGAAGTGATTATTTGT
CTTGACTGCTCCAGTTCCATGGAGGGTGTGACATTCTTGCAAGCCAAGGAAATCGCCTTG
CATGCGCTGTCCTTGGTGGGTGAGAAGCAGAAAGTAAATATTATCCAGTTCGGCACAGGT
TACAAGGAGCTATTTTCGTATCCTAAGCATATCACAAGCAATACCGCGGCAGCAGAGTTC
ATCATGTCTGCCACACCTACCATGGGGAACACAGACTTCTGGAAAACACTCCGATATCTT
AGCTTATTGTACCCTGCTCGAGGGTCACGGAACATCCTCCTGGTGTCTGATGGGCACCTC
CAGGATGAGAGCCTGACATTACAGCTCGTGAAGAGGAGCCGCCCGCACACCAGGTTATTC
GCCTGCGGTATCGGTTCTACAGCAAATCGTCACGTCTTAAGGATTTTGTCCCAGTGTGGT
GCCGGAGTATTTGAATATTTTAATGCAAAATCCAAGCATAGTTGGAGAAAACAGATAGAA
GACCAAATGACCAGGCTATGTTCTCCGAGTTGCCACTCTGTCTCCGTCAAATGGCAGCAA
CTCAATCCAGATGCGCCCGAGGCCCTGCAGGCCCCAGCCCAGGTGCCATCCTTGTTTCGC
AATGATCGACTCCTTGTCTATGGATTCATTCCTCACTGCACACAGGCAACTCTGTGTGCA
CTAATTCAAGAGAAAGAATTTTGTACAATGGTGTCGACTACTGAGCTTCAGAAGACAACT
GGAACTATGATCCACAAGCTGGCAGCCCGAGCTCTAATCAGAGATTATGAAGATGGCATT
CTTCACGAAAATGAAACCAGTCATGAGATGAAAAAACAAACCTTGAAATCTCTGATTATT
AAACTCAGTAAAGAAAACTCTCTCATAACACAATTTACAAGCTTTGTGGCAGTTGAGAAA
AGGGATGAGAATGAGTCACCTTTTCCTGATATTCCAAAAGTTTCTGAACTTATTGCCAAA
GAAGATGTAGACTTCCTGCCCTACATGAGCTGGCAGGGGGAACCCCAAGAAGCCGTCAGG
AACCAGTCTCTTTTAGCATCCTCTGAGTGGCCAGAATTACGTTTATCCAAACGAAAACAT
AGGAAAATTCCATTTTCCAAAAGAAAAATGGAATTATCTCAGCCAGAAGTTTCTGAAGAT
TTTGAAGAGGATGCCTTAGGTGTACTACCAGCTTTCACATCAAATTTGGAACGTGGACGT
GTGGAAAAGCTATTGGATTTAAGTTGGACAGAGTCATGTAAACCAACAGCAACTGAACCA
CTATTTAAGAAAGTCAGTCCATGGGAAACATCTACTTCTAGCTTTTTTCCTATTTTGGCT
CCGGCCGTTGGTTCCTATCTTACCCCGACTACCCGCGCTCACAGTCCTGCTTCCTTGTCT
TTTGCCTCATATCGTCAGGTAGCTAGTTTCGGTTCAGCTGCTCCTCCCAGACAGTTTGAT
GCATCTCAATTCAGCCAAGGCCCTGTGCCTGGCACTTGTGCTGACTGGATCCCACAGTCG
GCGTCTTGTCCCACAGGACCTCCCCAGAACCCACCTTCTGCACCCTATTGTGGCATTGTT
TTTTCAGGGAGCTCATTAAGCTCTGCACAGTCTGCTCCACTGCAACATCCTGGAGGCTTT
ACTACCAGGCCTTCTGCTGGCACCTTCCCTGAGCTGGATTCTCCCCAGCTTCATTTCTCT
CTTCCTACAGACCCTGATCCCATCAGAGGTTTTGGGTCTTATCATCCCTCTGCTTACTCT
CCTTTTCATTTTCAACCTTCCGCAGCCTCTTTGACTGCCAACCTTAGGCTGCCAATGGCC
TCTGCTTTACCTGAGGCTCTTTGCAGTCAGTCCCGGACTACCCCAGTAGATCTCTGTCTT
CTAGAAGAATCAGTAGGCAGTCTCGAAGGAAGTCGATGTCCTGTCTTTGCTTTTCAAAGT
TCTGACACAGAAAGTGATGAGCTATCAGAAGTACTTCAAGACAGCTGCTTTTTACAAATA
AAATGTGATACAAAAGATGACAGTATCCCGTGCTTTCTGGAAGTAAAAGAAGAGGATGAA
ATAGTGTGCACACAACACTGGCAGGATGCTGTGCCTTGGACAGAACTCCTCAGTCTACAG
ACAGAGGATGGCTTCTGGAAACTTACACCAGAACTGGGACTTATATTAAATCTTAATACA
AATGGTTTGCACAGCTTTCTTAAACAAAAAGGCATTCAATCTCTAGGTGTAAAAGGAAGA
GAATGTCTCCTGGACCTAATTGCCACAATGCTGGTACTACAGTTTATTCGCACCAGGTTG
GAAAAAGAGGGAATAGTGTTCAAATCACTGATGAAAATGGATGACCCTTCTATTTCCAGG
AATATTCCCTGGGCTTTTGAGGCAATAAAGCAAGCAAGTGAATGGGTAAGAAGAACTGAA
GGACAGTACCCATCTATCTGCCCACGGCTTGAACTGGGGAACGACTGGGACTCTGCCACC
AAGCAGTTGCTGGGACTCCAGCCCATAAGCACTGTGTCCCCTCTTCATAGAGTCCTCCAT
TACAGTCAAGGCTAA
Protein Properties
Number of Residues 1724
Molecular Weight 192592.915
Theoretical pI 5.653
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly [ADP-ribose] polymerase 4
MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ
LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP
DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR
DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL
ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI
LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC
ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV
NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD
SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT
TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL
PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP
LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN
LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK
QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL
PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL
HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL
SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG
AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL
NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI
LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK
EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED
FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS
ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS
LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL
LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE
IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR
ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE
GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG
GenBank ID Protein 3694920
UniProtKB/Swiss-Prot ID Q9UKK3
UniProtKB/Swiss-Prot Entry Name PARP4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF057160
GeneCard ID PARP4
GenAtlas ID PARP4
HGNC ID HGNC:271
References
General References Not Available