Identification
HMDB Protein ID CDBP02238
Secondary Accession Numbers Not Available
Name Dual oxidase 2
Description Not Available
Synonyms
  1. Large NOX 2
  2. Long NOX 2
  3. NADH/NADPH thyroid oxidase p138-tox
  4. NADPH oxidase/peroxidase DUOX2
  5. NADPH thyroid oxidase 2
  6. Thyroid oxidase 2
  7. p138 thyroid oxidase
Gene Name DUOX2
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
GO Classification
Biological Process
thyroid hormone generation
adenohypophysis morphogenesis
fertilization
inner ear development
thyroid gland development
multicellular organism growth
hydrogen peroxide catabolic process
response to cAMP
response to virus
bone mineralization
cuticle development
cytokine-mediated signaling pathway
hormone biosynthetic process
Cellular Component
apical plasma membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
electron carrier activity
iron ion binding
antioxidant activity
heme binding
oxidoreductase activity
fad or fadh2 binding
calcium ion binding
peroxidase activity
ion binding
Molecular Function
NAD(P)H oxidase activity
peroxidase activity
calcium ion binding
heme binding
Process
response to stimulus
response to stress
response to oxidative stress
metabolic process
oxidation reduction
Cellular Location
  1. Multi-pass membrane protein
  2. Apical cell membrane
Pathways
Gene Properties
Chromosome Location 15
Locus 15q15.3
SNPs DUOX2
Gene Sequence
>4647 bp
ATGCTCCGTGCAAGACCAGAGGCACTGATGCTCCTGGGAGCTCTTCTGACTGGATCCCTG
GGTCCATCGGGCAATCAGGACGCACTCTCACTGCCCTGGGAAGTGCAGCGCTATGACGGC
TGGTTTAACAACCTGAGGCACCACGAGCGTGGTGCTGTTGGCTGCCGGTTGCAGCGCCGC
GTACCAGCCAATTACGCCGACGGTGTGTATCAGGCTCTGGAGGAGCCGCAGCTGCCCAAC
CCGCGCCGGCTCAGCAACGCAGCCACGCGGGGCATAGCCGGCCTGCCGTCGCTCCACAAC
CGCACCGTACTGGGGGTCTTCTTTGGCTACCATGTTCTTTCCGACGTGGTGAGCGTGGAA
ACGCCCGGTTGCCCCGCCGAGTTCCTCAACATCCGCATCCCACCTGGAGACCCCGTGTTC
GACCCCGACCAGCGCGGGGACGTGGTGCTGCCCTTCCAGAGGAGCCGCTGGGACCCCGAG
ACCGGACGGAGTCCCAGCAACCCCCGGGACCTGGCCAACCAGGTGACGGGCTGGCTGGAC
GGCAGCGCCATCTATGGCTCCTCGCACTCCTGGAGCGACGCGCTGCGGAGCTTCTCGGGG
GGACAGCTGGCGTCGGGGCCCGACCCCGCTTTCCCCCGAGACTCGCAGAACCCCCTGCTC
ATGTGGGCGGCGCCCGACCCCGCCACCGGGCAGAACGGGCCCCGGGGGCTGTACGCCTTC
GGGGCAGAGAGAGGGAACCGGGAACCCTTCCTGCAGGCGCTGGGCCTGCTCTGGTTCCGC
TACCACAACCTGTGGGCGCAGAGGCTGGCCCGCCAGCACCCAGACTGGGAGGACGAGGAG
CTGTTCCAGCACGCACGCAAGAGGGTCATCGCCACCTACCAGAACATCGCTGTGTATGAG
TGGCTGCCCAGCTTCCTGCAGAAAACACTCCCGGAGTATACAGGATACCGTCCTTTCCTA
GACCCCAGCATCTCCCCGGAATTTGTGGTGGCCTCTGAGCAGTTCTTCTCTACCATGGTG
CCCCCTGGTGTCTACATGAGAAATGCCAGCTGTCATTTCCGGAAGGTCCTGAACAAGGGT
TTTCAAAGCTCCCAAGCTCTCAGGGTCTGCAACAACTACTGGATTCGGGAGAACCCCAAT
CTGAACAGTACCCAGGAGGTGAATGAGCTGCTGCTGGGAATGGCCTCCCAGATTTCGGAG
TTGGAGGACAACATAGTGGTTGAAGATCTGAGGGATTACTGGCCTGGCCCTGGCAAATTC
TCCCGTACAGACTATGTGGCCAGCAGCATCCAACGTGGCCGAGATATGGGGCTGCCCAGC
TATAGCCAGGCCCTGCTGGCCTTTGGGCTGGACATCCCAAGGAACTGGAGTGATCTCAAC
CCTAATGTGGACCCCCAGGTGCTGGAGGCCACAGCTGCCCTGTACAACCAGGACCTATCC
CAGCTAGAGCTGCTCCTTGGGGGGCTCCTGGAGAGCCATGGGGACCCTGGACCCCTGTTC
AGTGCCATTGTCCTCGACCAGTTTGTACGGCTGCGGGATGGTGACCGCTACTGGTTTGAG
AACACCAGGAATGGGCTGTTCTCCAAGAAGGAGATTGAAGACATCCGAAATACCACCCTG
CGGGACGTGCTGGTCGCTGTTATCAACATTGACCCCAGTGCCCTGCAGCCCAATGTCTTT
GTCTGGCATAAAGGTGCACCCTGCCCTCAACCTAAGCAGCTCACAACTGACGGCCTGCCC
CAGTGTGCACCCCTGACTGTGCTTGACTTCTTTGAAGGCAGCAGCCCTGGTTTTGCCATC
ACCATCATTGCTCTCTGCTGCCTTCCCTTAGTGAGTCTGCTTCTCTCTGGAGTGGTGGCC
TATTTCCGGGGCCGAGAACACAAGAAGCTACAAAAGAAACTCAAAGAGAGCGTGAAGAAG
GAAGCAGCCAAAGATGGAGTGCCAGCGATGGAGTGGCCAGGCCCCAAGGAGAGGAGCAGT
CCCATCATCATCCAGCTGCTGTCAGACAGGTGTCTGCAGGTCCTGAACAGGCATCTCACT
GTGCTCCGTGTGGTCCAGCTGCAGCCTCTGCAGCAGGTCAACCTCATCCTGTCCAACAAC
CGAGGATGCCGCACCCTGCTGCTCAAGATCCCTAAGGAGTATGACCTGGTGCTGCTGTTT
AGTTCTGAAGAGGAACGGGGCGCCTTTGTGCAGCAGCTATGGGACTTCTGCGTGCGCTGG
GCTCTGGGCCTCCATGTGGCTGAGATGAGCGAGAAGGAGCTATTTAGGAAGGCTGTGACA
AAGCAGCAGCGGGAACGCATCCTGGAGATCTTCTTCAGACACCTTTTTGCTCAGGTGCTG
GACATCAACCAGGCCGACGCAGGGACCCTGCCCCTGGACTCCTCCCAGAAGGTGCGGGAG
GCCCTGACCTGCGAGCTGAGCAGGGCCGAGTTTGCCGAGTCCCTGGGCCTCAAGCCCCAG
GACATGTTTGTGGAGTCCATGTTCTCTCTGGCTGACAAGGATGGCAATGGCTACCTGTCC
TTCCGAGAGTTCCTGGACATCCTGGTGGTCTTCATGAAAGGCTCCCCAGAGGATAAGTCC
CGTCTAATGTTTACCATGTATGACCTGGATGAGAATGGCTTCCTCTCCAAGGACGAATTC
TTCACCATGATGCGATCCTTCATCGAGATCTCCAACAACTGCCTGTCCAAGGCCCAGCTG
GCCGAGGTGGTGGAGTCTATGTTCCGGGAGTCGGGATTCCAGGACAAGGAGGAGCTGACA
TGGGAGGATTTTCACTTCATGCTGCGGGACCATGACAGCGAGCTCCGCTTCACGCAGCTC
TGTGTCAAAGGTGGAGGTGGAGGTGGAAATGGTATTAGAGATATCTTTAAACAAAACATC
AGCTGTCGAGTCTCGTTCATCACTCGGACACCTGGGGAGCGCTCCCACCCCCAGGGACTG
GGGCCCCCTGCCCCAGAAGCCCCAGAGCTGGGAGGCCCTGGACTGAAGAAGAGGTTTGGC
AAAAAGGCAGCAGTGCCCACTCCCCGGCTGTACACAGAGGCGCTGCAAGAGAAGATGCAG
CGAGGCTTCCTAGCCCAAAAGCTGCAGCAGTACAAGCGCTTCGTGGAGAACTACCGGAGG
CACATCGTGTGTGTGGCAATCTTCTCGGCCATCTGTGTTGGCGTGTTTGCAGATCGTGCT
TACTACTATGGCTTTGCCTCGCCACCCTCGGACATTGCACAGACCACCCTCGTGGGCATC
ATCCTGTCACGAGGCACGGCGGCCAGCGTCTCCTTCATGTTCTCTTATATCTTGCTCACC
ATGTGCCGCAACCTCATAACCTTCCTGCGAGAGACTTTCCTCAACCGCTATGTGCCTTTT
GATGCCGCAGTGGACTTCCACCGCTGGATCGCCATGGCTGCTGTTGTCCTGGCCATTTTG
CACAGTGCTGGCCACGCAGTCAATGTCTACATCTTCTCAGTCAGCCCACTCAGCCTGCTG
GCCTGCATATTCCCCAACGTCTTTGTGAATGATGGGTCCAAGCTTCCCCAGAAGTTCTAT
TGGTGGTTCTTCCAGACCGTCCCAGGTATGACAGGTGTGCTTCTGCTCCTGGTCCTGGCC
ATCATGTATGTCTTCGCCTCCCACCACTTCCGCCGCCGCAGCTTCCGGGGCTTCTGGCTG
ACCCACCACCTCTACATCCTGCTCTATGCCCTGCTCATCATCCATGGCAGCTATGCTCTG
ATCCAGCTGCCCACTTTCCACATCTACTTCCTGGTCCCGGCAATCATCTATGGAGGTGAC
AAGCTGGTGAGCCTGAGCCGGAAGAAGGTGGAGATCAGCGTGGTGAAGGCGGAGCTGCTG
CCCTCAGGAGTGACCTACCTGCAATTCCAGAGGCCCCAAGGCTTTGAGTACAAGTCAGGA
CAGTGGGTGCGGATCGCCTGCCTGGCTCTGGGGACCACCGAGTACCACCCCTTCACACTG
ACCTCCGCGCCCCATGAGGACACACTCAGCCTGCACATCCGGGCAGTGGGGCCCTGGACC
ACTCGCCTCAGGGAGATCTACTCATCCCCAAAGGGCAATGGCTGTGCTGGATACCCAAAG
CTGTACCTTGATGGACCGTTTGGAGAGGGCCATCAGGAGTGGCATAAATTTGAGGTGTCA
GTGTTGGTGGGAGGGGGCATTGGGGTCACCCCCTTTGCCTCCATCCTCAAAGACCTGGTC
TTCAAGTCATCCTTGGGCAGCCAAATGCTGTGTAAGAAGATCTACTTCATCTGGGTGACA
CGGACCCAGCGTCAGTTTGAGTGGCTGGCTGACATCATCCAAGAGGTGGAGGAGAACGAC
CACCAGGACCTGGTGTCTGTGCACATTTATGTCACCCAGCTGGCTGAGAAGTTCGACCTC
AGGACCACCATGCTATACATCTGCGAGCGGCACTTCCAGAAAGTGCTGAACCGGAGTCTG
TTCACGGGCCTGCGCTCCATCACCCACTTTGGCCGTCCCCCCTTCGAGCCCTTCTTCAAC
TCCCTGCAGGAGGTCCACCCACAGGTGCGCAAGATCGGGGTGTTCAGCTGCGGCCCTCCA
GGAATGACCAAGAATGTAGAGAAGGCCTGTCAGCTCGTCAACAGGCAGGACCGAGCCCAC
TTCATGCACCACTATGAGAACTTCTGA
Protein Properties
Number of Residues 1548
Molecular Weight 175362.865
Theoretical pI 7.854
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dual oxidase 2
MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR
VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE
TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD
GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF
GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE
WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG
FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF
SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS
QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL
RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI
TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS
PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF
SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL
DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS
FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL
AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI
SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ
RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI
ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL
HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA
IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD
KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL
TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS
VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND
HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN
SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF
GenBank ID Protein 132566532
UniProtKB/Swiss-Prot ID Q9NRD8
UniProtKB/Swiss-Prot Entry Name DUOX2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014080.4
GeneCard ID DUOX2
GenAtlas ID DUOX2
HGNC ID HGNC:13273
References
General References Not Available