| Identification |
|---|
| HMDB Protein ID
| CDBP02399 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nicotinamide riboside kinase 1 |
| Description
| Not Available |
| Synonyms
|
- NRK 1
- Nicotinic acid riboside kinase 1
- NmR-K 1
- RNK 1
- Ribosylnicotinamide kinase 1
- Ribosylnicotinic acid kinase 1
|
| Gene Name
| NMRK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.
|
| GO Classification
|
| Biological Process |
| NAD biosynthetic process |
| UMP biosynthetic process |
| Function |
| atp binding |
| phosphotransferase activity, alcohol group as acceptor |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| Molecular Function |
| metal ion binding |
| ATP binding |
| ribosylnicotinamide kinase activity |
| uridine kinase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | NAD(+) biosynthesis | Not Available | Not Available | | Nicotinate and Nicotinamide Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q21.13 |
| SNPs
| NRK1 |
| Gene Sequence
|
>600 bp
ATGAAAACATTTATCATTGGAATCAGTGGTGTGACAAACAGTGGCAAAACAACACTGGCT
AAGAATTTGCAGAAACACCTCCCAAATTGCAGTGTCATATCTCAGGATGATTTCTTCAAG
CCAGAGTCTGAGATAGAGACAGATAAAAATGGATTTTTGCAGTACGATGTGCTTGAAGCA
CTTAACATGGAAAAAATGATGTCAGCCATTTCCTGCTGGATGGAAAGCGCAAGACACTCT
GTGGTATCAACAGACCAGGAAAGTGCTGAGGAAATTCCCATTTTAATCATCGAAGGTTTT
CTTCTTTTTAATTATAAGCCCCTTGACACTATATGGAATAGAAGCTATTTCCTGACTATT
CCATATGAAGAATGTAAAAGGAGGAGGAGTACAAGGGTCTATCAGCCTCCAGACTCTCCG
GGATACTTTGATGGCCATGTGTGGCCCATGTATCTAAAGTACAGACAAGAAATGCAGGAC
ATCACATGGGAAGTTGTGTACCTGGATGGAACAAAATCTGAAGAGGACCTCTTTTTGCAA
GTATATGAAGATCTAATACAAGAACTAGCAAAGCAAAAGTGTTTGCAAGTGACAGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 199 |
| Molecular Weight
| 20152.76 |
| Theoretical pI
| 4.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide riboside kinase 1
MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEA
LNMEKMMSAISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTI
PYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQDITWEVVYLDGTKSEEDLFLQ
VYEDLIQELAKQKCLQVTA
|
| External Links |
|---|
| GenBank ID Protein
| 7020749 |
| UniProtKB/Swiss-Prot ID
| Q9NWW6 |
| UniProtKB/Swiss-Prot Entry Name
| NRK1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK000566 |
| GeneCard ID
| NRK1 |
| GenAtlas ID
| NRK1 |
| HGNC ID
| HGNC:26057 |
| References |
|---|
| General References
| Not Available |