| Identification |
|---|
| HMDB Protein ID
| CDBP01751 |
| Secondary Accession Numbers
| Not Available |
| Name
| Proline dehydrogenase 1, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Proline oxidase
- Proline oxidase 2
- p53-induced gene 6 protein
|
| Gene Name
| PRODH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in proline dehydrogenase activity |
| Specific Function
| Converts proline to delta-1-pyrroline-5-carboxylate.
|
| GO Classification
|
| Biological Process |
| proline catabolic process |
| proline catabolic process to glutamate |
| intrinsic apoptotic signaling pathway in response to oxidative stress |
| cellular nitrogen compound metabolic process |
| 4-hydroxyproline catabolic process |
| glutamate biosynthetic process |
| Cellular Component |
| mitochondrial matrix |
| mitochondrial inner membrane |
| Function |
| proline dehydrogenase activity |
| catalytic activity |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity |
| Molecular Function |
| proline dehydrogenase activity |
| FAD binding |
| Process |
| proline metabolic process |
| oxidation reduction |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| proline catabolic process |
| glutamate metabolic process |
| glutamate biosynthetic process |
| metabolic process |
| cellular metabolic process |
| glutamine family amino acid metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Arginine and Proline Metabolism |    |  | | L-proline degradation into L-glutamate | Not Available | Not Available | | Prolidase Deficiency (PD) |    | Not Available | | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) |    | Not Available | | Hyperprolinemia Type II |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q11.21 |
| SNPs
| PRODH |
| Gene Sequence
|
>1551 bp
ATGCTGGAATTTGTGATGAGAGAGTGGAAAAAATCCAGGAAACTTCTAGGACAGAGGCTA
TTCAACAAGCTCATGAAGATGACCTTCTATGGGCATTTTGTAGCCGGGGAGGACCAGGAG
TCCATCCAGCCCCTGCTTCGGCACTACAGGGCCTTCGGTGTCAGCGCCATCCTGGACTAT
GGAGTGGAGGAGGACCTGAGCCCCGAGGAGGCAGAGCACAAGGAGATGGAGTCCTGCTCC
TCGGCTGCGGAGAGGGATGGCAGTGGCACGAATAAGCGGGACAAGCAATACCAGGCCCAC
CGGGCTTTCGGGGACCGCAGGAATGGTGTCATCAGTGCCCGCACCTACTTCTACGCCAAT
GAGGCCAAGTGCGACAGCCACATGGAGACATTCTTGCGCTGCATCGAAGCCTCAGGTAGA
GTCAGCGATGACGGCTTCATAGCCATTAAGCTCACAGCACTGGGGAGACCCCAGTTTCTG
CTGCAGTTCTCAGAGGTGCTGGCCAAGTGGAGGTGCTTCTTTCACCAAATGGCTGTGGAG
CAAGGGCAGGCGGGCCTGGCTGCCATGGACACCAAGCTGGAGGTGGCGGTGCTGCAGGAA
AGTGTCGCAAAGTTGGGCATCGCATCCAGGGCTGAGATTGAGGACTGGTTCACGGCAGAG
ACCCTGGGAGTGTCTGGCACCATGGACCTGCTGGACTGGAGCAGCCTCATCGACAGCAGG
ACCAAGCTGTCCAAGCACCTGGTAGTCCCCAACGCACAGACAGGACAGCTGGAGCCCCTG
CTGTCCCGGTTCACTGAGGAGGAGGAGCTACAGATGACCAGGATGCTACAGCGGATGGAT
GTCCTGGCCAAGAAAGCCACAGAGATGGGCGTGCGGCTGATGGTGGATGCCGAGCAGACC
TACTTCCAGCCGGCCATCAGCCGCCTGACGCTGGAGATGCAGCGGAAGTTCAATGTGGAG
AAGCCGCTCATCTTCAACACATACCAGTGCTACCTCAAGGATGCCTATGACAATGTGACC
CTGGACGTGGAGCTGGCTCGCCGTGAGGGCTGGTGTTTTGGGGCCAAGCTGGTGCGGGGC
GCATACCTGGCCCAGGAGCGAGCCCGTGCGGCAGAGATCGGCTATGAGGACCCCATCAAC
CCCACGTACGAGGCCACCAACGCCATGTACCACAGGTGCCTGGACTACGTGTTGGAGGAG
CTGAAGCACAACGCCAAGGCCAAGGTGATGGTGGCCTCCCACAATGAGGACACAGTGCGC
TTCGCACTGCGCAGGATGGAGGAGCTGGGCCTGCATCCTGCTGACCACCAGGTGTACTTT
GGACAGCTGCTAGGCATGTGTGACCAGATCAGCTTCCCGCTGGGCCAGGCCGGCTACCCC
GTGTACAAGTACGTGCCCTATGGCCCCGTGATGGAGGTGCTGCCCTACTTGTCCCGCCGT
GCCCTGGAGAACAGCAGCCTCATGAAGGGCACCCATCGGGAGCGGCAGTTGCTGTGGCTG
GAGCTCTTGAGGCGGCTCCGAACTGGCAACCTCTTCCATCGCCCTGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 516 |
| Molecular Weight
| 56196.675 |
| Theoretical pI
| 6.336 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Proline dehydrogenase, mitochondrial
MLEFVMREWKKSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDY
GVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYAN
EAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVE
QGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSR
TKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQT
YFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRG
AYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVR
FALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRR
ALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
|
| External Links |
|---|
| GenBank ID Protein
| 2677802 |
| UniProtKB/Swiss-Prot ID
| O43272 |
| UniProtKB/Swiss-Prot Entry Name
| PROD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U82381 |
| GeneCard ID
| PRODH |
| GenAtlas ID
| PRODH |
| HGNC ID
| HGNC:9453 |
| References |
|---|
| General References
| Not Available |