Identification |
HMDB Protein ID
| CDBP01751 |
Secondary Accession Numbers
| Not Available |
Name
| Proline dehydrogenase 1, mitochondrial |
Description
| Not Available |
Synonyms
|
- Proline oxidase
- Proline oxidase 2
- p53-induced gene 6 protein
|
Gene Name
| PRODH |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in proline dehydrogenase activity |
Specific Function
| Converts proline to delta-1-pyrroline-5-carboxylate.
|
GO Classification
|
Biological Process |
proline catabolic process |
proline catabolic process to glutamate |
intrinsic apoptotic signaling pathway in response to oxidative stress |
cellular nitrogen compound metabolic process |
4-hydroxyproline catabolic process |
glutamate biosynthetic process |
Cellular Component |
mitochondrial matrix |
mitochondrial inner membrane |
Function |
proline dehydrogenase activity |
catalytic activity |
oxidoreductase activity, acting on the ch-nh group of donors |
oxidoreductase activity |
Molecular Function |
proline dehydrogenase activity |
FAD binding |
Process |
proline metabolic process |
oxidation reduction |
cellular amino acid and derivative metabolic process |
cellular amino acid metabolic process |
proline catabolic process |
glutamate metabolic process |
glutamate biosynthetic process |
metabolic process |
cellular metabolic process |
glutamine family amino acid metabolic process |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Arginine and Proline Metabolism | | | L-proline degradation into L-glutamate | Not Available | Not Available | Prolidase Deficiency (PD) | | Not Available | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) | | Not Available | Hyperprolinemia Type II | | Not Available |
|
Gene Properties |
Chromosome Location
| 22 |
Locus
| 22q11.21 |
SNPs
| PRODH |
Gene Sequence
|
>1551 bp
ATGCTGGAATTTGTGATGAGAGAGTGGAAAAAATCCAGGAAACTTCTAGGACAGAGGCTA
TTCAACAAGCTCATGAAGATGACCTTCTATGGGCATTTTGTAGCCGGGGAGGACCAGGAG
TCCATCCAGCCCCTGCTTCGGCACTACAGGGCCTTCGGTGTCAGCGCCATCCTGGACTAT
GGAGTGGAGGAGGACCTGAGCCCCGAGGAGGCAGAGCACAAGGAGATGGAGTCCTGCTCC
TCGGCTGCGGAGAGGGATGGCAGTGGCACGAATAAGCGGGACAAGCAATACCAGGCCCAC
CGGGCTTTCGGGGACCGCAGGAATGGTGTCATCAGTGCCCGCACCTACTTCTACGCCAAT
GAGGCCAAGTGCGACAGCCACATGGAGACATTCTTGCGCTGCATCGAAGCCTCAGGTAGA
GTCAGCGATGACGGCTTCATAGCCATTAAGCTCACAGCACTGGGGAGACCCCAGTTTCTG
CTGCAGTTCTCAGAGGTGCTGGCCAAGTGGAGGTGCTTCTTTCACCAAATGGCTGTGGAG
CAAGGGCAGGCGGGCCTGGCTGCCATGGACACCAAGCTGGAGGTGGCGGTGCTGCAGGAA
AGTGTCGCAAAGTTGGGCATCGCATCCAGGGCTGAGATTGAGGACTGGTTCACGGCAGAG
ACCCTGGGAGTGTCTGGCACCATGGACCTGCTGGACTGGAGCAGCCTCATCGACAGCAGG
ACCAAGCTGTCCAAGCACCTGGTAGTCCCCAACGCACAGACAGGACAGCTGGAGCCCCTG
CTGTCCCGGTTCACTGAGGAGGAGGAGCTACAGATGACCAGGATGCTACAGCGGATGGAT
GTCCTGGCCAAGAAAGCCACAGAGATGGGCGTGCGGCTGATGGTGGATGCCGAGCAGACC
TACTTCCAGCCGGCCATCAGCCGCCTGACGCTGGAGATGCAGCGGAAGTTCAATGTGGAG
AAGCCGCTCATCTTCAACACATACCAGTGCTACCTCAAGGATGCCTATGACAATGTGACC
CTGGACGTGGAGCTGGCTCGCCGTGAGGGCTGGTGTTTTGGGGCCAAGCTGGTGCGGGGC
GCATACCTGGCCCAGGAGCGAGCCCGTGCGGCAGAGATCGGCTATGAGGACCCCATCAAC
CCCACGTACGAGGCCACCAACGCCATGTACCACAGGTGCCTGGACTACGTGTTGGAGGAG
CTGAAGCACAACGCCAAGGCCAAGGTGATGGTGGCCTCCCACAATGAGGACACAGTGCGC
TTCGCACTGCGCAGGATGGAGGAGCTGGGCCTGCATCCTGCTGACCACCAGGTGTACTTT
GGACAGCTGCTAGGCATGTGTGACCAGATCAGCTTCCCGCTGGGCCAGGCCGGCTACCCC
GTGTACAAGTACGTGCCCTATGGCCCCGTGATGGAGGTGCTGCCCTACTTGTCCCGCCGT
GCCCTGGAGAACAGCAGCCTCATGAAGGGCACCCATCGGGAGCGGCAGTTGCTGTGGCTG
GAGCTCTTGAGGCGGCTCCGAACTGGCAACCTCTTCCATCGCCCTGCCTAG
|
Protein Properties |
Number of Residues
| 516 |
Molecular Weight
| 56196.675 |
Theoretical pI
| 6.336 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Proline dehydrogenase, mitochondrial
MLEFVMREWKKSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDY
GVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYAN
EAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVE
QGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSR
TKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQT
YFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRG
AYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVR
FALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRR
ALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
|
External Links |
GenBank ID Protein
| 2677802 |
UniProtKB/Swiss-Prot ID
| O43272 |
UniProtKB/Swiss-Prot Entry Name
| PROD_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| U82381 |
GeneCard ID
| PRODH |
GenAtlas ID
| PRODH |
HGNC ID
| HGNC:9453 |
References |
General References
| Not Available |