Identification
HMDB Protein ID CDBP00377
Secondary Accession Numbers Not Available
Name GDP-mannose 4,6 dehydratase
Description Not Available
Synonyms
  1. GDP-D-mannose dehydratase
  2. GMD
Gene Name GMDS
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
GO Classification
Biological Process
Notch signaling pathway
GDP-mannose metabolic process
'de novo' GDP-L-fucose biosynthetic process
Cellular Component
cytoplasm
Component
cell part
intracellular
Function
binding
catalytic activity
lyase activity
coenzyme binding
carbon-oxygen lyase activity
hydro-lyase activity
cofactor binding
gdp-mannose 4,6-dehydratase activity
Molecular Function
GDP-mannose 4,6-dehydratase activity
NADP+ binding
Process
metabolic process
mannose metabolic process
cellular metabolic process
small molecule metabolic process
alcohol metabolic process
gdp-mannose metabolic process
monosaccharide metabolic process
hexose metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 6
Locus 6p25
SNPs GMDS
Gene Sequence
>1119 bp
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGC
AAGCCCAGGAACGTGGCGCTCATCACCGGTATCACAGGCCAGGATGGTTCCTACCTGGCT
GAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATG
AAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTA
AAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAG
ACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGG
AAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTT
GCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACT
CGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGG
TTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGT
GTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGAT
CTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAA
CAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCAC
GCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGA
Protein Properties
Number of Residues 372
Molecular Weight 39053.295
Theoretical pI 7.081
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>GDP-mannose 4,6 dehydratase
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O60547
UniProtKB/Swiss-Prot Entry Name GMDS_HUMAN
PDB IDs
GenBank Gene ID AF042377
GeneCard ID GMDS
GenAtlas ID GMDS
HGNC ID HGNC:4369
References
General References Not Available