Identification |
HMDB Protein ID
| CDBP00377 |
Secondary Accession Numbers
| Not Available |
Name
| GDP-mannose 4,6 dehydratase |
Description
| Not Available |
Synonyms
|
- GDP-D-mannose dehydratase
- GMD
|
Gene Name
| GMDS |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
|
GO Classification
|
Biological Process |
Notch signaling pathway |
GDP-mannose metabolic process |
'de novo' GDP-L-fucose biosynthetic process |
Cellular Component |
cytoplasm |
Component |
cell part |
intracellular |
Function |
binding |
catalytic activity |
lyase activity |
coenzyme binding |
carbon-oxygen lyase activity |
hydro-lyase activity |
cofactor binding |
gdp-mannose 4,6-dehydratase activity |
Molecular Function |
GDP-mannose 4,6-dehydratase activity |
NADP+ binding |
Process |
metabolic process |
mannose metabolic process |
cellular metabolic process |
small molecule metabolic process |
alcohol metabolic process |
gdp-mannose metabolic process |
monosaccharide metabolic process |
hexose metabolic process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | GDP-L-fucose biosynthesis via de novo pathway | Not Available | Not Available | Fructose and mannose metabolism | Not Available | | Amino sugar and nucleotide sugar metabolism | Not Available | | Fructose and Mannose Degradation | | | Fructosuria | | Not Available |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6p25 |
SNPs
| GMDS |
Gene Sequence
|
>1119 bp
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGC
AAGCCCAGGAACGTGGCGCTCATCACCGGTATCACAGGCCAGGATGGTTCCTACCTGGCT
GAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATG
AAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTA
AAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAG
ACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGG
AAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTT
GCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACT
CGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGG
TTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGT
GTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGAT
CTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAA
CAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCAC
GCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGA
|
Protein Properties |
Number of Residues
| 372 |
Molecular Weight
| 39053.295 |
Theoretical pI
| 7.081 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>GDP-mannose 4,6 dehydratase
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| O60547 |
UniProtKB/Swiss-Prot Entry Name
| GMDS_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF042377 |
GeneCard ID
| GMDS |
GenAtlas ID
| GMDS |
HGNC ID
| HGNC:4369 |
References |
General References
| Not Available |