Identification |
HMDB Protein ID
| CDBP00847 |
Secondary Accession Numbers
| Not Available |
Name
| UDP-glucose 4-epimerase |
Description
| Not Available |
Synonyms
|
- Galactowaldenase
- UDP-galactose 4-epimerase
|
Gene Name
| GALE |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
|
GO Classification
|
Biological Process |
small molecule metabolic process |
galactose catabolic process |
cellular metabolic process |
Cellular Component |
cytosol |
Function |
binding |
catalytic activity |
udp-glucose 4-epimerase activity |
racemase and epimerase activity |
racemase and epimerase activity, acting on carbohydrates and derivatives |
coenzyme binding |
cofactor binding |
isomerase activity |
Molecular Function |
coenzyme binding |
UDP-glucose 4-epimerase activity |
nucleotide binding |
Process |
metabolic process |
galactose metabolic process |
primary metabolic process |
carbohydrate metabolic process |
cellular metabolic process |
small molecule metabolic process |
alcohol metabolic process |
monosaccharide metabolic process |
hexose metabolic process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Amino sugar and nucleotide sugar metabolism | Not Available | ![Map00520](https://www.genome.jp/kegg/misc/thumbnail/map00520.gif) | Nucleotide Sugars Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000031/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000031/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000031/thumb?image_type=simple) | ![Map00520](https://www.genome.jp/kegg/misc/thumbnail/map00520.gif) | Galactosemia II (GALK) | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000471/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000471/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000471/thumb?image_type=simple) | Not Available | Galactosemia III | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000472/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000472/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000472/thumb?image_type=simple) | Not Available | Galactose Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000159/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000159/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000159/thumb?image_type=simple) | ![Map00052](https://www.genome.jp/kegg/misc/thumbnail/map00052.gif) |
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1p36-p35 |
SNPs
| GALE |
Gene Sequence
|
>1047 bp
ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG
GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT
GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG
GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC
AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG
CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG
GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG
TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC
AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA
GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT
CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG
GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT
TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA
CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG
GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG
GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG
ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT
CCTTCAGGCTTTGGCACGCAAGCCTGA
|
Protein Properties |
Number of Residues
| 348 |
Molecular Weight
| 38281.435 |
Theoretical pI
| 6.721 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>UDP-glucose 4-epimerase
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
|
External Links |
GenBank ID Protein
| 1119217 |
UniProtKB/Swiss-Prot ID
| Q14376 |
UniProtKB/Swiss-Prot Entry Name
| GALE_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| L41668 |
GeneCard ID
| GALE |
GenAtlas ID
| GALE |
HGNC ID
| HGNC:4116 |
References |
General References
| Not Available |