| Identification |
|---|
| HMDB Protein ID
| CDBP03472 |
| Secondary Accession Numbers
| Not Available |
| Name
| Metalloreductase STEAP3 |
| Description
| Not Available |
| Synonyms
|
- Dudulin-2
- Six-transmembrane epithelial antigen of prostate 3
- Tumor suppressor-activated pathway protein 6
- hTSAP6
- hpHyde
- pHyde
|
| Gene Name
| STEAP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP |
| GO Classification
|
| Component |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| electron carrier activity |
| iron ion binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Endosome membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q14.2 |
| SNPs
| STEAP3 |
| Gene Sequence
|
>1467 bp
ATGCCAGAAGAGATGGACAAGCCACTGATCAGCCTCCACCTGGTGGACAGCGATAGTAGC
CTTGCCAAGGTCCCCGATGAGGCCCCCAAAGTGGGCATCCTGGGTAGCGGGGACTTTGCC
CGCTCCCTGGCCACACGCCTGGTGGGCTCTGGCTTCAAAGTGGTGGTGGGGAGCCGCAAC
CCCAAACGCACAGCCAGGCTGTTTCCCTCAGCGGCCCAAGTGACTTTCCAAGAGGAGGCA
GTGAGCTCCCCGGAGGTCATCTTTGTGGCTGTGTTCCGGGAGCACTACTCTTCACTGTGC
AGTCTCAGTGACCAGCTGGCGGGCAAGATCCTGGTGGATGTGAGCAACCCTACAGAGCAA
GAGCACCTTCAGCATCGTGAGTCCAATGCTGAGTACCTGGCCTCCCTCTTCCCCACTTGC
ACAGTGGTCAAGGCCTTCAATGTCATCTCTGCCTGGACCCTGCAGGCTGGCCCAAGGGAT
GGTAACAGGCAGGTGCCCATCTGCGGTGACCAGCCAGAAGCCAAGCGTGCTGTCTCGGAG
ATGGCGCTCGCCATGGGCTTCATGCCCGTGGACATGGGATCCCTGGCGTCAGCCTGGGAG
GTGGAGGCCATGCCCCTGCGCCTCCTCCCGGCCTGGAAGGTGCCCACCCTGCTGGCCCTG
GGGCTCTTCGTCTGCTTCTATGCCTACAACTTCGTCCGGGACGTTCTGCAGCCCTATGTG
CAGGAAAGCCAGAACAAGTTCTTCAAGCTGCCCGTGTCCGTGGTCAACACCACACTGCCG
TGCGTGGCCTACGTGCTGCTGTCACTCGTGTACTTGCCCGGCGTGCTGGCGGCTGCCCTG
CAGCTGCGGCGCGGCACCAAGTACCAGCGCTTCCCCGACTGGCTGGACCACTGGCTACAG
CACCGCAAGCAGATCGGGCTGCTCAGCTTCTTCTGCGCCGCCCTGCACGCCCTCTACAGC
TTCTGCTTGCCGCTGCGCCGCGCCCACCGCTACGACCTGGTCAACCTGGCAGTCAAGCAG
GTCTTGGCCAACAAGAGCCACCTCTGGGTGGAGGAGGAGGTCTGGCGGATGGAGATCTAC
CTCTCCCTGGGAGTGCTGGCCCTCGGCACGTTGTCCCTGCTGGCCGTGACCTCACTGCCG
TCCATTGCAAACTCGCTCAACTGGAGGGAGTTCAGCTTCGTTCAGTCCTCACTGGGCTTT
GTGGCCCTCGTGCTGAGCACACTGCACACGCTCACCTACGGCTGGACCCGCGCCTTCGAG
GAGAGCCGCTACAAGTTCTACCTGCCTCCCACCTTCACGCTCACGCTGCTGGTGCCCTGC
GTCGTCATCCTGGCCAAAGCCCTGTTTCTCCTGCCCTGCATCAGCCGCAGACTCGCCAGG
ATCCGGAGAGGCTGGGAGAGGGAGAGCACCATCAAGTTCACGCTGCCCACAGACCACGCC
CTGGCCGAGAAGACGAGCCACGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 488 |
| Molecular Weight
| 54600.1 |
| Theoretical pI
| 8.74 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["208-228", "259-279", "305-325", "359-379", "391-411", "434-454"]
|
| Protein Sequence
|
>Metalloreductase STEAP3
MPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRN
PKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTEQ
EHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSE
MALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDVLQPYV
QESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQ
HRKQIGLLSFFCAALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIY
LSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFE
ESRYKFYLPPTFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHA
LAEKTSHV
|
| External Links |
|---|
| GenBank ID Protein
| 56549147 |
| UniProtKB/Swiss-Prot ID
| Q658P3 |
| UniProtKB/Swiss-Prot Entry Name
| STEA3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001008410.1 |
| GeneCard ID
| STEAP3 |
| GenAtlas ID
| STEAP3 |
| HGNC ID
| HGNC:24592 |
| References |
|---|
| General References
| Not Available |