Cannabis Compound Database: Showing Protein NAD-dependent protein deacetylase sirtuin-4 (CDBP04091)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04091

Secondary Accession Numbers

Not Available

Name

NAD-dependent protein deacetylase sirtuin-4

Description

Not Available

Synonyms

SIR2-like protein 4
NAD-dependent ADP-ribosyltransferase sirtuin-4
Regulatory protein SIR2 homolog 4

Gene Name

SIRT4

Protein Type

Enzyme

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity.

GO Classification

Biological Process
protein ADP-ribosylation
negative regulation of insulin secretion
chromatin silencing
Cellular Component
mitochondrial matrix
Function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
ion binding
cation binding
metal ion binding
binding
nucleotide binding
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
transition metal ion binding
zinc ion binding
nad or nadh binding
nad binding
Molecular Function
metal ion binding
NAD+ ADP-ribosyltransferase activity
NAD+ binding
hydrolase activity
Process
regulation of transcription
post-translational protein modification
macromolecule modification
protein modification process
metabolic process
macromolecule metabolic process
protein amino acid deacetylation
gene silencing
chromatin silencing
cellular process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression

Cellular Location

Mitochondrion matrix

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

12q

SNPs

SIRT4

Gene Sequence

>945 bp
ATGAAGATGAGCTTTGCGTTGACTTTCAGGTCAGCAAAAGGCCGTTGGATCGCAAACCCC
AGCCAGCCGTGCTCGAAAGCCTCCATTGGGTTATTTGTGCCAGCAAGTCCTCCTCTGGAC
CCTGAGAAGGTCAAAGAGTTACAGCGCTTCATCACCCTTTCCAAGAGACTCCTTGTGATG
ACTGGGGCAGGAATCTCCACCGAATCGGGGATACCAGACTACAGGTCAGAAAAAGTGGGG
CTTTATGCCCGCACTGACCGCAGGCCCATCCAGCATGGTGATTTTGTCCGGAGTGCCCCA
ATCCGCCAGCGGTACTGGGCGAGAAACTTCGTAGGCTGGCCTCAATTCTCCTCCCACCAG
CCTAACCCTGCACACTGGGCTTTGAGCACCTGGGAGAAACTCGGAAAGCTGTACTGGTTG
GTGACCCAAAATGTGGATGCTTTGCACACCAAGGCGGGGAGTCGGCGCCTGACAGAGCTC
CACGGATGCATGGACAGGGTCCTGTGCTTGGATTGTGGGGAACAGACTCCCCGGGGGGTG
CTGCAAGAGCGTTTCCAAGTCCTGAACCCCACCTGGAGTGCTGAGGCCCATGGCCTGGCT
CCTGATGGTGACGTCTTTCTCTCAGAGGAGCAAGTCCGGAGCTTTCAGGTCCCAACCTGC
GTTCAATGTGGAGGCCATCTGAAACCAGATGTCGTTTTCTTCGGGGACACAGTGAACCCT
GACAAGGTTGATTTTGTGCACAAGCGTGTAAAAGAAGCCGACTCCCTCTTGGTGGTGGGA
TCATCCTTGCAGGTATACTCTGGTTACAGGTTTATCCTCACTGCCTGGGAGAAGAAGCTC
CCGATTGCAATACTGAACATTGGGCCCACACGGTCGGATGACTTGGCGTGTCTGAAACTG
AATTCTCGTTGTGGAGAGTTGCTGCCTTTGATAGACCCATGCTGA

Protein Properties

Number of Residues

314

Molecular Weight

35187.205

Theoretical pI

8.775

Pfam Domain Function

SIR2 (PF02146 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>NAD-dependent ADP-ribosyltransferase sirtuin-4
MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVM
TGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQ
PNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGV
LQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNP
DKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKL
NSRCGELLPLIDPC

External Links

GenBank ID Protein

5225324

UniProtKB/Swiss-Prot ID

Q9Y6E7

UniProtKB/Swiss-Prot Entry Name

SIRT4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF083109

GeneCard ID