| Identification |
|---|
| HMDB Protein ID
| CDBP04074 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nicotinamide riboside kinase 2 |
| Description
| Not Available |
| Synonyms
|
- Integrin beta-1-binding protein 3
- MIBP
- Muscle integrin-binding protein
- NRK 2
- Nicotinic acid riboside kinase 2
- NmR-K 2
- RNK 2
- Ribosylnicotinamide kinase 2
- Ribosylnicotinic acid kinase 2
|
| Gene Name
| NMRK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
|
| GO Classification
|
| Biological Process |
| NAD biosynthetic process |
| negative regulation of myoblast differentiation |
| Cellular Component |
| intracellular |
| Molecular Function |
| metal ion binding |
| ATP binding |
| ribosylnicotinamide kinase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | NAD(+) biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| ITGB1BP3 |
| Gene Sequence
|
>693 bp
ATGAAGCTCATCGTGGGCATCGGAGGCATGACCAACGGCGGCAAGACCACGCTGACCAAC
AGCCTGCTCAGAGCCCTGCCCAACTGCTGCGTGATCCATCAGGATGACTTCTTCAAGCCC
CAAGACCAAATAGCAGTTGGGGAAGACGGCTTCAAACAGTGGGACGTGCTGGAGTCTCTG
GACATGGAGGCCATGCTGGACACCGTGCAGGCCTGGCTGAGCAGCCCGCAGAAGTTTGCC
CGTGCCCACGGGGTCAGCGTCCAGCCAGAGGCCTCGGACACCCACATCCTCCTCCTGGAA
GGCTTCCTGCTCTACAGCTACAAGCCCCTGGTGGACTTGTACAGCCGCCGGTACTTCCTG
ACCGTCCCGTATGAAGAGTGCAAGTGGAGGAGAAGTACCCGCAACTACACAGTCCCTGAT
CCCCCCGGCCTCTTCGATGGCCACGTGTGGCCCATGTACCAGAAGTATAGGCAGGAGATG
GAGGCCAACGGTGTGGAAGTGGTCTACCTGGACGGCATGAAGTCCCGAGAGGAGCTCTTC
CGTGAAGTCCTGGAAGACATTCAGAACTCGCTGCTGAACCGCTCCCAGGAATCAGCCCCC
TCCCCGGCTCGCCCAGCCAGGACACAGGGACCCGGACGCGGATGCGGCCACAGAACGGCC
AGGCCTGCAGCGTCCCAGCAGGACAGCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 230 |
| Molecular Weight
| 26045.335 |
| Theoretical pI
| 6.131 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide riboside kinase 2
MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESL
DMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFL
TVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELF
REVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM
|
| External Links |
|---|
| GenBank ID Protein
| 24762248 |
| UniProtKB/Swiss-Prot ID
| Q9NPI5 |
| UniProtKB/Swiss-Prot Entry Name
| NRK2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_170678.2 |
| GeneCard ID
| ITGB1BP3 |
| GenAtlas ID
| ITGB1BP3 |
| HGNC ID
| HGNC:17871 |
| References |
|---|
| General References
| Not Available |