Cannabis Compound Database: Showing Protein Inositol-3-phosphate synthase 1 (CDBP02463)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP02463

Secondary Accession Numbers

Not Available

Name

Inositol-3-phosphate synthase 1

Description

Not Available

Synonyms

IPS 1
MI-1-P synthase
MIP synthase
Myo-inositol 1-phosphate synthase A1
Myo-inositol-1-phosphate synthase
hINO1
hIPS
Myo-inositol 1-phosphate synthase

Gene Name

ISYNA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in inositol-3-phosphate synthase activity

Specific Function

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

GO Classification

Biological Process
inositol biosynthetic process
phospholipid biosynthetic process
Cellular Component
cytoplasm
Function
binding
catalytic activity
isomerase activity
intramolecular lyase activity
inositol-3-phosphate synthase activity
Molecular Function
inositol-3-phosphate synthase activity
nucleotide binding
Process
phospholipid biosynthetic process
organophosphate metabolic process
phospholipid metabolic process
inositol metabolic process
inositol biosynthetic process
metabolic process
small molecule metabolic process
alcohol metabolic process
polyol metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Inositol Metabolism
Inositol Phosphate Metabolism
myo-inositol biosynthesis	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

19p13.11

SNPs

ISYNA1

Gene Sequence

>1677 bp
ATGGAGGCCGCCGCCCAGTTCTTCGTCGAGAGCCCGGACGTGGTCTACGGCCCCGAGGCC
ATCGAGGCGCAATACGAGTACCGGACGACGCGCGTCAGCCGCGAGGGTGGCGTTCTCAAG
GTGCACCCCACGTCCACGCGCTTCACCTTCCGGACCGCCCGGCAGGTGCCCCGGCTCGGG
GTCATGCTTGTCGGCTGGGGCGGGAACAACGGCTCCACACTCACCGCCGCGGTGCTGGCC
AATCGACTGCGTTTGTCCTGGCCCACGCGCAGCGGCCGCAAGGAGGCCAACTACTACGGC
TCGCTGACTCAGGCGGGCACCGTGAGCCTGGGCCTGGACGCCGAGGGCCAGGAGGTGTTC
GTACCCTTCAGCGCGGTGCTGCCCATGGTGGCGCCCAACGACCTCGTGTTCGATGGCTGG
GACATCTCGTCGCTGAACCTGGCCGAGGCGATGCGGCGCGCGAAGGTGCTGGACTGGGGG
CTGCAGGAGCAACTGTGGCCGCACATGGAGGCCCTGCGGCCCCGGCCTTCTGTTTACATC
CCCGAATTCATCGCGGCCAACCAGAGCGCGCGCGCGGACAACCTCATCCCAGGCTCGCGT
GCGCAGCAGCTGGAGCAGATCCGCAGGGACATCCGAGACTTCCGGTCTAGCGCGGGGCTG
GACAAAGTCATAGTGCTGTGGACGGCGAACACGGAGCGCTTCTGTGAGGTGATTCCAGGC
CTCAACGACACAGCCGAGAACCTGCTGCGCACCATTGAGCTCGGTCTGGAGGTGTCGCCC
TCCACGCTCTTCGCCGTGGCCAGCATCCTGGAGGGCTGTGCCTTCCTCAATGGGTCTCCG
CAGAACACCCTGGTGCCCGGAGCTCTTGAGCTCGCGTGGCAGCACCGGGTTTTTGTGGGC
GGAGATGACTTCAAGTCAGGCCAGACCAAAGTCAAGTCCGTGCTTGTGGACTTCCTCATT
GGCTCCGGCCTCAAGACCATGTCCATCGTGAGTTACAACCACCTGGGCAACAACGATGGG
GAGAACCTATCGGCGCCATTGCAGTTCCGCTCTAAGGAGGTGTCCAAGAGCAACGTGGTG
GACGACATGGTGCAGAGCAACCCAGTGCTCTATACGCCCGGCGAAGAGCCTGACCACTGC
GTGGTCATCAAGTATGTGCCGTACGTGGGTGACAGCAAGCGCGCGCTGGATGAGTATACC
TCGGAGCTGATGCTGGGCGGAACCAACACACTGGTGCTGCACAACACGTGTGAGGACTCG
CTGCTGGCCGCACCCATCATGCTGGACCTAGCGCTGCTGACCGAGCTGTGCCAGCGCGTG
AGCTTCTGCACTGACATGGACCCCGAGCCGCAGACCTTCCACCCCGTGCTGTCCCTGCTC
AGCTTCCTCTTCAAGGCGCCACTAGTGCCGCCCGGCAGCCCGGTGGTCAATGCGCTTTTC
CGCCAGCGCAGCTGCATCGAGAACATCCTCAGGGCCTGCGTGGGGCTCCCGCCACAGAAC
CACATGCTCCTGGAACACAAAATGGAGCGCCCAGGGCCCAGCCTCAAGCGAGTTGGACCC
GTGGCTGCCACCTACCCTATGTTGAACAAGAAAGGACCGGTACCCGCTGCCACCAATGGC
TGCACCGGTGATGCCAATGGGCATCTGCAAGAGGAGCCCCCAATGCCCACCACCTGA

Protein Properties

Number of Residues

558

Molecular Weight

55135.445

Theoretical pI

5.035

Pfam Domain Function

Inos-1-P_synth (PF01658 )
NAD_binding_5 (PF07994 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Inositol-3-phosphate synthase 1
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLG
VMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVF
VPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYI
PEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPG
LNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVG
GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVV
DDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
LLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALF
RQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNG
CTGDANGHLQEEPPMPTT

External Links

GenBank ID Protein

7705558

UniProtKB/Swiss-Prot ID

Q9NPH2

UniProtKB/Swiss-Prot Entry Name

INO1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_016368.4

GeneCard ID