| Identification |
|---|
| HMDB Protein ID
| CDBP00846 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD-dependent protein deacetylase sirtuin-6 |
| Description
| Not Available |
| Synonyms
|
- SIR2-like protein 6
- Regulatory protein SIR2 homolog 6
|
| Gene Name
| SIRT6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
|
| GO Classification
|
| Biological Process |
| protein ADP-ribosylation |
| regulation of double-strand break repair via homologous recombination |
| Cellular Component |
| nuclear telomeric heterochromatin |
| nucleoplasm |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| nad or nadh binding |
| nad binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Molecular Function |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
| NAD+ ADP-ribosyltransferase activity |
| zinc ion binding |
| NAD+ binding |
| NAD-dependent histone deacetylase activity (H3-K9 specific) |
| metal ion binding |
| Process |
| regulation of transcription |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid deacetylation |
| gene silencing |
| chromatin silencing |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
|
| Cellular Location
|
- Nucleus
- nucleoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| SIRT6 |
| Gene Sequence
|
>1068 bp
ATGTCGGTGAATTACGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGCCTC
CCGGAGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGGTGTGGGAACTGGCGAGGCTG
GTCTGGCAGTCTTCCAGTGTGGTGTTCCACACGGGTGCCGGCATCAGCACTGCCTCTGGC
ATCCCCGACTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGTCTGGCCCCC
AAGTTCGACACCACCTTTGAGAGCGCGCGGCCCACGCAGACCCACATGGCGCTGGTGCAG
CTGGAGCGCGTGGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCATGTG
CGCTCAGGCTTCCCCAGGGACAAACTGGCAGAGCTCCACGGGAACATGTTTGTGGAAGAA
TGTGCCAAGTGTAAGACGCAGTACGTCCGAGACACAGTCGTGGGCACCATGGGCCTGAAG
GCCACGGGCCGGCTCTGCACCGTGGCTAAGGCAAGGGGGCTGCGAGCCTGCAGGGGAGAG
CTGAGGGACACCATCCTAGACTGGGAGGACTCCCTGCCCGACCGGGACCTGGCACTCGCC
GATGAGGCCAGCAGGAACGCCGACCTGTCCATCACGCTGGGTACATCGCTGCAGATCCGG
CCCAGCGGGAACCTGCCGCTGGCTACCAAGCGCCGGGGAGGCCGCCTGGTCATCGTCAAC
CTGCAGCCCACCAAGCACGACCGCCATGCTGACCTCCGCATCCATGGCTACGTTGACGAG
GTCATGACCCGGCTCATGGAGCACCTGGGGCTGGAGATCCCCGCCTGGGACGGCCCCCGT
GTGCTGGAGAGGGCGCTGCCACCCCTGCCCCGCCCGCCCACCCCCAAGCTGGAGCCCAAG
GAGGAATCTCCCACCCGGATCAACGGCTCTATCCCCGCCGGCCCCAAGCAGGAGCCCTGC
GCCCAGCACAACGGCTCAGAGCCCGCCAGCCCCAAACGGGAGCGGCCCACCAGCCCTGCC
CCCCACAGACCCCCCAAAAGGGTGAAGGCCAAGGCGGTCCCCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 355 |
| Molecular Weight
| 36064.295 |
| Theoretical pI
| 9.743 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-6
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
|
| External Links |
|---|
| GenBank ID Protein
| 7243749 |
| UniProtKB/Swiss-Prot ID
| Q8N6T7 |
| UniProtKB/Swiss-Prot Entry Name
| SIRT6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF233396 |
| GeneCard ID
| SIRT6 |
| GenAtlas ID
| SIRT6 |
| HGNC ID
| HGNC:14934 |
| References |
|---|
| General References
| Not Available |