| Identification |
|---|
| HMDB Protein ID
| CDBP00848 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly [ADP-ribose] polymerase 3 |
| Description
| Not Available |
| Synonyms
|
- ADPRT-3
- IRT1
- NAD(+) ADP-ribosyltransferase 3
- PARP-3
- Poly[ADP-ribose] synthase 3
- hPARP-3
- pADPRT-3
- ADP-ribosyltransferase diphtheria toxin-like 3
- ARTD3
|
| Gene Name
| PARP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
|
| GO Classification
|
| Biological Process |
| DNA repair |
| protein ADP-ribosylation |
| Cellular Component |
| centriole |
| nucleus |
| Function |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| catalytic activity |
| Molecular Function |
| NAD+ ADP-ribosyltransferase activity |
| catalytic activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid adp-ribosylation |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
- cytoskeleton
- centrosome
- centrosome
- centriole
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Base excision repair | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p21.31-p21.1 |
| SNPs
| PARP3 |
| Gene Sequence
|
>1602 bp
ATGGCTCCAAAGCCGAAGCCCTGGGTACAGACTGAGGGCCCTGAGAAGAAGAAGGGCCGG
CAGGCAGGAAGGGAGGAGGACCCCTTCCGCTCCACCGCTGAGGCCCTCAAGGCCATACCC
GCAGAGAAGCGCATAATCCGCGTGGATCCAACATGTCCACTCAGCAGCAACCCCGGGACC
CAGGTGTATGAGGACTACAACTGCACCCTGAACCAGACCAACATCGAGAACAACAACAAC
AAGTTCTACATCATCCAGCTGCTCCAAGACAGCAACCGCTTCTTCACCTGCTGGAACCAC
TGGGGCCGTGTGGGAGAGGTCGGCCAGTCAAAGATCAACCACTTCACAAGGCTAGAAGAT
GCAAAGAAGGACTTTGAGAAGAAATTTCGGGAAAAGACCAAGAACAACTGGGCAGAGCGG
GACCACTTTGTGTCTCACCCGGGCAAGTACACACTTATCGAAGTACAGGCAGAGGATGAG
GCCCAGGAAGCTGTGGTGAAGGTGGACAGAGGCCCAGTGAGGACTGTGACTAAGCGGGTG
CAGCCCTGCTCCCTGGACCCAGCCACGCAGAAGCTCATCACTAACATCTTCAGCAAGGAG
ATGTTCAAGAACACCATGGCCCTCATGGACCTGGATGTGAAGAAGATGCCCCTGGGAAAG
CTGAGCAAGCAACAGATTGCACGGGGTTTCGAGGCCTTGGAGGCGCTGGAGGAGGCCCTG
AAAGGCCCCACGGATGGTGGCCAAAGCCTGGAGGAGCTGTCCTCACACTTTTACACCGTC
ATCCCGCACAACTTCGGCCACAGCCAGCCCCCGCCCATCAATTCCCCTGAGCTTCTGCAG
GCCAAGAAGGACATGCTGCTGGTGCTGGCGGACATCGAGCTGGCCCAGGCCCTGCAGGCA
GTCTCTGAGCAGGAGAAGACGGTGGAGGAGGTGCCACACCCCCTGGACCGAGACTACCAG
CTTCTCAAGTGCCAGCTGCAGCTGCTAGACTCTGGAGCACCTGAGTACAAGGTGATACAG
ACCTACTTAGAACAGACTGGCAGCAACCACAGGTGCCCTACACTTCAACACATCTGGAAA
GTAAACCAAGAAGGGGAGGAAGACAGATTCCAGGCCCACTCCAAACTGGGTAATCGGAAG
CTGCTGTGGCATGGCACCAACATGGCCGTGGTGGCCGCCATCCTCACTAGTGGGCTCCGC
ATCATGCCACATTCTGGTGGGCGTGTTGGCAAGGGCATCTACTTTGCCTCAGAGAACAGC
AAGTCAGCTGGATATGTTATTGGCATGAAGTGTGGGGCCCACCATGTCGGCTACATGTTC
CTGGGTGAGGTGGCCCTGGGCAGAGAGCACCATATCAACACGGACAACCCCAGCTTGAAG
AGCCCACCTCCTGGCTTCGACAGTGTCATTGCCCGAGGCCACACCGAGCCTGATCCGACC
CAGGACACTGAGTTGGAGCTGGATGGCCAGCAAGTGGTGGTGCCCCAGGGCCAGCCTGTG
CCCTGCCCAGAGTTCAGCAGCTCCACATTCTCCCAGAGCGAGTACCTCATCTACCAGGAG
AGCCAGTGTCGCCTGCGCTACCTGCTGGAGGTCCACCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 533 |
| Molecular Weight
| 60845.685 |
| Theoretical pI
| 6.742 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 3
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
|
| External Links |
|---|
| GenBank ID Protein
| 158634482 |
| UniProtKB/Swiss-Prot ID
| Q9Y6F1 |
| UniProtKB/Swiss-Prot Entry Name
| PARP3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_005485.4 |
| GeneCard ID
| PARP3 |
| GenAtlas ID
| PARP3 |
| HGNC ID
| HGNC:273 |
| References |
|---|
| General References
| Not Available |