Identification
HMDB Protein ID CDBP03504
Secondary Accession Numbers Not Available
Name All-trans-retinol 13,14-reductase
Description Not Available
Synonyms
  1. All-trans-13,14-dihydroretinol saturase
  2. RetSat
  3. PPAR-alpha-regulated and starvation-induced gene protein
Gene Name RETSAT
Protein Type Enzyme
Biological Properties
General Function Involved in electron carrier activity
Specific Function Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
GO Classification
Biological Process
retinol metabolic process
Cellular Component
endoplasmic reticulum membrane
nuclear outer membrane
Function
catalytic activity
electron carrier activity
oxidoreductase activity
Molecular Function
all-trans-retinol 13,14-reductase activity
Cellular Location
  1. Peripheral membrane protein
  2. Endoplasmic reticulum membrane
Pathways
Gene Properties
Chromosome Location 2
Locus 2p11.2
SNPs RETSAT
Gene Sequence
>1833 bp
ATGTGGCTTCCGCTGGTGCTGCTCCTGGCTGTGCTGCTGCTGGCCGTCCTCTGCAAAGTT
TACTTGGGACTATTCTCTGGCAGCTCCCCGAATCCTTTCTCCGAAGATGTCAAACGGCCC
CCAGCGCCCCTGGTAACTGACAAGGAGGCCAGGAAGAAGGTTCTCAAACAAGCTTTTTCA
GCCAACCAAGTGCCGGAGAAGCTGGATGTGGTGGTAATTGGCAGTGGCTTTGGGGGCCTG
GCTGCAGCTGCAATTCTAGCTAAAGCTGGCAAGCGAGTCCTGGTGCTGGAACAACATACC
AAGGCAGGGGGCTGCTGTCATACCTTTGGAAAGAATGGCCTTGAATTTGACACAGGAATC
CATTACATTGGGCGTATGGAAGAGGGCAGCATTGGCCGTTTTATCTTGGACCAGATCACT
GAAGGGCAGCTGGACTGGGCTCCCCTGTCCTCTCCTTTTGACATCATGGTACTGGAAGGG
CCCAATGGCCGAAAGGAGTACCCCATGTACAGTGGAGAGAAAGCCTACATTCAGGGCCTC
AAGGAGAAGTTTCCACAGGAGGAAGCTATCATTGACAAGTATATAAAGCTGGTTAAGGTG
GTATCCAGTGGAGCCCCTCATGCCATCCTGTTGAAATTCCTCCCATTGCCCGTGGTTCAG
CTCCTCGACAGGTGTGGGCTGCTGACTCGTTTCTCTCCATTCCTTCAAGCATCCACCCAG
AGCCTGGCTGAGGTCCTGCAGCAGCTGGGGGCCTCCTCTGAGCTCCAGGCAGTACTCAGC
TACATCTTCCCCACTTACGGTGTCACCCCCAACCACAGTGCCTTTTCCATGCACGCCCTG
CTGGTCAACCACTACATGAAAGGAGGCTTTTATCCCCGAGGGGGTTCCAGTGAAATTGCC
TTCCACACCATCCCTGTGATTCAGCGGGCTGGGGGCGCTGTCCTCACAAAGGCCACTGTG
CAGAGTGTGTTGCTGGACTCAGCTGGGAAAGCCTGTGGTGTCAGTGTGAAGAAGGGGCAT
GAGCTGGTGAACATCTATTGCCCCATCGTGGTCTCCAACGCAGGACTGTTCAACACCTAT
GAACACCTACTGCCGGGGAACGCCCGCTGCCTGCCAGGTGTGAAGCAGCAACTGGGGACG
GTGCGGCCCGGCTTAGGCATGACCTCTGTTTTCATCTGCCTGCGAGGCACCAAGGAAGAC
CTGCATCTGCCGTCCACCAACTACTATGTTTACTATGACACGGACATGGACCAGGCGATG
GAGCGCTACGTCTCCATGCCCAGGGAAGAGGCTGCGGAACACATCCCTCTTCTCTTCTTC
GCTTTCCCATCAGCCAAAGATCCGACCTGGGAGGACCGATTCCCAGGCCGGTCCACCATG
ATCATGCTCATACCCACTGCCTACGAGTGGTTTGAGGAGTGGCAGGCGGAGCTGAAGGGA
AAGCGGGGCAGTGACTATGAGACCTTCAAAAACTCCTTTGTGGAAGCCTCTATGTCAGTG
GTCCTGAAACTGTTCCCACAGCTGGAGGGGAAGGTGGAGAGTGTGACTGCAGGATCCCCA
CTCACCAACCAGTTCTATCTGGCTGCTCCCCGAGGTGCCTGCTACGGGGCTGACCATGAC
CTGGGCCGCCTGCACCCTTGTGTGATGGCCTCCTTGAGGGCCCAGAGCCCCATCCCCAAC
CTCTATCTGACAGGCCAGGATATCTTCACCTGTGGACTGGTCGGGGCCCTGCAAGGTGCC
CTGCTGTGCAGCAGCGCCATCCTGAAGCGGAACTTGTACTCAGACCTTAAGAATCTTGAT
TCTAGGATCCGGGCACAGAAGAAAAAGAATTAG
Protein Properties
Number of Residues 610
Molecular Weight 66818.935
Theoretical pI 8.274
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>All-trans-retinol 13,14-reductase
MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFS
ANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGI
HYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGL
KEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQ
SLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIA
FHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTY
EHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAM
ERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKG
KRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHD
LGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLD
SRIRAQKKKN
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6NUM9
UniProtKB/Swiss-Prot Entry Name RETST_HUMAN
PDB IDs Not Available
GenBank Gene ID AY358568
GeneCard ID RETSAT
GenAtlas ID RETSAT
HGNC ID HGNC:25991
References
General References Not Available