Identification |
HMDB Protein ID
| CDBP02507 |
Secondary Accession Numbers
| Not Available |
Name
| Cytochrome b5 reductase 4 |
Description
| Not Available |
Synonyms
|
- Flavohemoprotein b5/b5R
- N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
- b5+b5R
- cb5/cb5R
|
Gene Name
| CYB5R4 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in heme binding |
Specific Function
| NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
|
GO Classification
|
Biological Process |
insulin secretion |
response to antibiotic |
superoxide metabolic process |
cell development |
detection of oxygen |
generation of precursor metabolites and energy |
glucose homeostasis |
Cellular Component |
endoplasmic reticulum |
perinuclear region of cytoplasm |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
iron ion binding |
heme binding |
oxidoreductase activity |
Molecular Function |
NAD(P)H oxidase activity |
metal ion binding |
cytochrome-b5 reductase activity |
heme binding |
Process |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Endoplasmic reticulum
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6pter-q22.33 |
SNPs
| CYB5R4 |
Gene Sequence
|
>1566 bp
ATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGTCGCAGCAGCGTGTCGCCTCC
GGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTG
ACCAAAAGTGGAAAGGATCTAACGGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAA
GAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATATGCATAAGAGGTTTCGTTTAT
AATGTCAGCCCTTATATGGAGTATCATCCTGGTGGAGAAGATGAACTAATGAGAGCAGCA
GGATCAGATGGTACTGAACTTTTTGATCAGGTTCATCGTTGGGTCAATTATGAATCCATG
CTGAAAGAATGCCTGGTTGGCAGAATGGCCATTAAACCTGCTGTTCTGAAAGACTATCGT
GAGGAGGAAAAGAAAGTCTTAAATGGCATGCTTCCCAAGAGCCAAGTGACAGATACACTT
GCCAAAGAAGGTCCTAGTTATCCAAGCTATGATTGGTTCCAAACAGACTCTTTAGTCACC
ATTGCCATATATACTAAACAGAAGGATATCAATTTAGACTCAATAATAGTTGATCATCAG
AATGATTCCTTTAGAGCAGAAACAATTATTAAGGATTGTTTATATCTTATACATATTGGG
CTAAGCCATGAGGTTCAGGAAGATTTTTCTGTGCGGGTTGTTGAGAGTGTGGGAAAAATA
GAGATTGTTCTACAAAAAAAAGAGAATACTTCTTGGGACTTTCTTGGCCATCCCCTGAAG
AATCATAATTCACTTATTCCAAGGAAAGATACAGGTTTGTACTACAGAAAGTGCCAGTTA
ATTTCCAAGGAAGATGTTACTCATGATACGAGGCTTTTCTGTTTGATGCTGCCACCAAGC
ACTCATCTTCAAGTGCCCATTGGGCAACATGTTTACCTCAAGCTACCTATTACAGGTACA
GAAATAGTAAAGCCATATACACCTGTATCTGGTTCCTTACTCTCAGAGTTCAAGGAACCA
GTTCTTCCCAACAATAAATACATCTACTTTTTGATAAAAATCTATCCCACTGGACTCTTC
ACACCAGAGCTTGATCGTCTTCAGATTGGAGATTTTGTTTCTGTAAGCAGTCCTGAGGGC
AATTTTAAAATATCCAAGTTCCAAGAATTAGAAGATCTCTTTTTGTTGGCAGCTGGAACA
GGCTTCACACCAATGGTTAAAATACTGAATTATGCTTTGACTGATATACCCAGTCTCAGG
AAAGTGAAGCTGATGTTCTTCAATAAAACAGAAGATGATATAATTTGGAGAAGCCAATTG
GAGAAATTAGCATTTAAAGATAAAAGACTGGATGTTGAATTTGTTCTCTCAGCACCTATT
TCTGAATGGAATGGCAAACAGGGACATATTTCACCAGCTCTTCTTTCTGAATTTTTGAAA
AGAAATTTGGACAAATCCAAAGTTCTCGTCTGCATTTGTGGACCAGTGCCATTTACAGAA
CAAGGAGTAAGGTTGCTGCATGATCTCAACTTTTCCAAAAATGAGATCCATAGTTTTACA
GCATAA
|
Protein Properties |
Number of Residues
| 521 |
Molecular Weight
| 59473.19 |
Theoretical pI
| 7.724 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Cytochrome b5 reductase 4
MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESM
LKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVT
IAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKI
EIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPS
THLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLF
TPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLR
KVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLK
RNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA
|
External Links |
GenBank ID Protein
| 84875541 |
UniProtKB/Swiss-Prot ID
| Q7L1T6 |
UniProtKB/Swiss-Prot Entry Name
| NB5R4_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_016230.3 |
GeneCard ID
| CYB5R4 |
GenAtlas ID
| CYB5R4 |
HGNC ID
| HGNC:20147 |
References |
General References
| Not Available |