| Identification |
|---|
| HMDB Protein ID
| CDBP02502 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3-hydroxybutyrate dehydrogenase type 2 |
| Description
| Not Available |
| Synonyms
|
- Dehydrogenase/reductase SDR family member 6
- Oxidoreductase UCPA
- R-beta-hydroxybutyrate dehydrogenase
|
| Gene Name
| BDH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
|
| GO Classification
|
| Biological Process |
| siderophore biosynthetic process |
| fatty acid beta-oxidation |
| heme metabolic process |
| iron ion homeostasis |
| Cellular Component |
| cytoplasm |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| NAD binding |
| 3-hydroxybutyrate dehydrogenase activity |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Synthesis and degradation of ketone bodies | Not Available |  | | Butanoate metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q24 |
| SNPs
| BDH2 |
| Gene Sequence
|
>738 bp
ATGGGTCGACTTGATGGGAAAGTCATCATCCTGACGGCCGCTGCTCAGGGGATTGGCCAA
GCAGCTGCCTTAGCTTTTGCAAGAGAAGGTGCCAAAGTCATAGCCACAGACATTAATGAG
TCCAAACTTCAGGAACTGGAAAAGTACCCGGGTATTCAAACTCGTGTCCTTGATGTCACA
AAGAAGAAACAAATTGATCAGTTTGCCAATGAAGTTGAGAGACTTGATGTTCTCTTTAAT
GTTGCTGGTTTTGTCCATCATGGAACTGTCCTGGATTGTGAGGAGAAAGACTGGGACTTC
TCGATGAATCTCAATGTGCGCAGCATGTACCTGATGATCAAGGCATTCCTTCCTAAAATG
CTTGCTCAGAAATCTGGCAATATTATCAACATGTCTTCTGTGGCTTCCAGCGTCAAAGGA
GTTGTGAACAGATGTGTGTACAGCACAACCAAGGCAGCCGTGATTGGCCTCACAAAATCT
GTGGCTGCAGATTTCATCCAGCAGGGCATCAGGTGCAACTGTGTGTGCCCAGGAACAGTT
GATACGCCATCTCTACAAGAAAGAATACAAGCCAGAGGAAATCCTGAAGAGGCACGGAAT
GATTTCCTGAAGAGACAAAAGACGGGAAGATTCGCAACTGCAGAAGAAATAGCCATGCTC
TGCGTGTATTTGGCTTCTGATGAATCTGCTTATGTAACTGGTAACCCTGTCATCATTGAT
GGAGGCTGGAGCTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| 26723.57 |
| Theoretical pI
| 7.651 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-hydroxybutyrate dehydrogenase type 2
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVT
KKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM
LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV
DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID
GGWSL
|
| External Links |
|---|
| GenBank ID Protein
| 66933014 |
| UniProtKB/Swiss-Prot ID
| Q9BUT1 |
| UniProtKB/Swiss-Prot Entry Name
| BDH2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_020139.3 |
| GeneCard ID
| BDH2 |
| GenAtlas ID
| BDH2 |
| HGNC ID
| HGNC:32389 |
| References |
|---|
| General References
| Not Available |