Identification
HMDB Protein ID CDBP02502
Secondary Accession Numbers Not Available
Name 3-hydroxybutyrate dehydrogenase type 2
Description Not Available
Synonyms
  1. Dehydrogenase/reductase SDR family member 6
  2. Oxidoreductase UCPA
  3. R-beta-hydroxybutyrate dehydrogenase
Gene Name BDH2
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
GO Classification
Biological Process
siderophore biosynthetic process
fatty acid beta-oxidation
heme metabolic process
iron ion homeostasis
Cellular Component
cytoplasm
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
NAD binding
3-hydroxybutyrate dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 4
Locus 4q24
SNPs BDH2
Gene Sequence
>738 bp
ATGGGTCGACTTGATGGGAAAGTCATCATCCTGACGGCCGCTGCTCAGGGGATTGGCCAA
GCAGCTGCCTTAGCTTTTGCAAGAGAAGGTGCCAAAGTCATAGCCACAGACATTAATGAG
TCCAAACTTCAGGAACTGGAAAAGTACCCGGGTATTCAAACTCGTGTCCTTGATGTCACA
AAGAAGAAACAAATTGATCAGTTTGCCAATGAAGTTGAGAGACTTGATGTTCTCTTTAAT
GTTGCTGGTTTTGTCCATCATGGAACTGTCCTGGATTGTGAGGAGAAAGACTGGGACTTC
TCGATGAATCTCAATGTGCGCAGCATGTACCTGATGATCAAGGCATTCCTTCCTAAAATG
CTTGCTCAGAAATCTGGCAATATTATCAACATGTCTTCTGTGGCTTCCAGCGTCAAAGGA
GTTGTGAACAGATGTGTGTACAGCACAACCAAGGCAGCCGTGATTGGCCTCACAAAATCT
GTGGCTGCAGATTTCATCCAGCAGGGCATCAGGTGCAACTGTGTGTGCCCAGGAACAGTT
GATACGCCATCTCTACAAGAAAGAATACAAGCCAGAGGAAATCCTGAAGAGGCACGGAAT
GATTTCCTGAAGAGACAAAAGACGGGAAGATTCGCAACTGCAGAAGAAATAGCCATGCTC
TGCGTGTATTTGGCTTCTGATGAATCTGCTTATGTAACTGGTAACCCTGTCATCATTGAT
GGAGGCTGGAGCTTGTGA
Protein Properties
Number of Residues 245
Molecular Weight 26723.57
Theoretical pI 7.651
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>3-hydroxybutyrate dehydrogenase type 2
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVT
KKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM
LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV
DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID
GGWSL
GenBank ID Protein 66933014
UniProtKB/Swiss-Prot ID Q9BUT1
UniProtKB/Swiss-Prot Entry Name BDH2_HUMAN
PDB IDs
GenBank Gene ID NM_020139.3
GeneCard ID BDH2
GenAtlas ID BDH2
HGNC ID HGNC:32389
References
General References Not Available