| Identification |
|---|
| HMDB Protein ID
| CDBP00836 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-lactate dehydrogenase A-like 6A |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| LDHAL6A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Specific Function
| Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.
|
| GO Classification
|
| Biological Process |
| glycolysis |
| cellular carbohydrate metabolic process |
| Cellular Component |
| cytoplasm |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| binding |
| catalytic activity |
| lactate dehydrogenase activity |
| l-lactate dehydrogenase activity |
| Molecular Function |
| L-lactate dehydrogenase activity |
| nucleotide binding |
| Process |
| glycolysis |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| cellular carbohydrate metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| oxidation reduction |
| glucose catabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | pyruvate fermentation to lactate | Not Available | Not Available | | Glycolysis / Gluconeogenesis | Not Available |  | | Cysteine and methionine metabolism | Not Available |  | | Cysteine Metabolism |    | | | Beta-mercaptolactate-cysteine disulfiduria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.1 |
| SNPs
| LDHAL6A |
| Gene Sequence
|
>999 bp
ATGGCAACTATCAAGAGTGAACTTATTAAGAATTTCGCGGAAGAGGAGGCCATTCATCAC
AATAAGATCTCCATTGTAGGAACTGGATCGGTTGGTGTGGCTTGTGCTATCAGCATCTTA
TTAAAAGGTTTGAGTGATGAACTTGTCCTTGTGGATGTTGATGAAGGCAAACTGAAGGGT
GAGACAATGGATCTTCAACATGGCAGCCCTTTTATGAAAATGCCAAATATTGTCTCCAGC
AAAGATTACCTGGTCACTGCAAACTCCAATCTAGTGATTATCACAGCAGGTGCACGCCAG
AAAAAAGGAGAAACACGCCTTGATTTAGTCCAGCGAAATGTATCCATCTTTAAATTAATG
ATTCCCAATATTACCCAGTACAGTCCTCACTGCAAACTGCTTATTGTTACTAATCCAGTG
GATATCTTAACTTATGTAGCCTGGAAGTTGAGTGGATTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGTAATCTGGACTCTGCTCGTTTTCGTTACTTTATTGGGCAAAGGCTTGGCATC
CACTCTGAAAGCTGTCATGGGCTGATCCTTGGAGAGCATGGCGACTCAAGTGTTCCTGTG
TGGAGTGGTGTGAACATTGCTGGCGTCCCTCTGAAGGATCTGAACCCAGATATAGGAACT
GATAAAGATCCTGAGCAGTGGGAAAATGTCCACAAAAAAGTGATTTCCAGTGGCTATGAG
ATGGTCAAAATGAAAGGTTATACTTCTTGGGGCATTAGCCTATCTGTAGCTGATTTAACA
GAAAGTATTTTGAAGAATCTTAGGAGAGTGCATCCAGTTTCTACCCTAAGTAAGGGCCTC
TATGGAATAAATGAAGACATATTCCTTAGTGTCCCATGTATCCTGGGAGAGAATGGTATC
ACAGACCTCATAAAAGTAAAACTGACTCTTGAAGAGGAGGCCTGCTTGCAAAAGAGTGCA
GAAACACTTTGGGAAATTCAGAAGGAGCTCAAGCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 332 |
| Molecular Weight
| 36507.015 |
| Theoretical pI
| 6.989 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-lactate dehydrogenase A-like 6A
MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKG
ETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLM
IPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGI
HSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYE
MVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGI
TDLIKVKLTLEEEACLQKSAETLWEIQKELKL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6ZMR3 |
| UniProtKB/Swiss-Prot Entry Name
| LDH6A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY581313 |
| GeneCard ID
| LDHAL6A |
| GenAtlas ID
| LDHAL6A |
| HGNC ID
| HGNC:28335 |
| References |
|---|
| General References
| Not Available |