Identification
HMDB Protein ID CDBP02503
Secondary Accession Numbers Not Available
Name Glycerol-3-phosphate dehydrogenase 1-like protein
Description Not Available
Synonyms
  1. GPD1-L
Gene Name GPD1L
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
GO Classification
Biological Process
regulation of heart rate
regulation of sodium ion transmembrane transporter activity
regulation of ventricular cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell membrane depolarization
phosphatidic acid biosynthetic process
triglyceride biosynthetic process
carbohydrate metabolic process
glycerol-3-phosphate catabolic process
NAD metabolic process
negative regulation of peptidyl-serine phosphorylation
negative regulation of protein kinase C signaling cascade
positive regulation of protein localization to cell surface
positive regulation of sodium ion transport
Cellular Component
cytosol
plasma membrane
glycerol-3-phosphate dehydrogenase complex
Component
cell part
intracellular part
cytoplasm
macromolecular complex
protein complex
glycerol-3-phosphate dehydrogenase complex
Function
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
protein binding
coenzyme binding
cofactor binding
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
identical protein binding
protein homodimerization activity
glycerol-3-phosphate dehydrogenase [nad+] activity
binding
nucleotide binding
catalytic activity
nad or nadh binding
Molecular Function
NAD binding
glycerol-3-phosphate dehydrogenase [NAD+] activity
sodium channel regulator activity
Process
alcohol metabolic process
polyol metabolic process
alditol metabolic process
glycerol metabolic process
glycerol-3-phosphate metabolic process
oxidation reduction
glycerol-3-phosphate catabolic process
metabolic process
primary metabolic process
carbohydrate metabolic process
small molecule metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 3
Locus 3p22.3
SNPs GPD1L
Gene Sequence
>1056 bp
ATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTT
GCAAAAATAATTGGTAATAATGTCAAGAAACTTCAGAAATTTGCCTCCACAGTCAAGATG
TGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACAGACATCATAAATAATGACCAT
GAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAAT
CTTAGCGAGGCTGTGCAGGATGCAGACCTGCTGGTGTTTGTCATTCCCCACCAGTTCATT
CACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAGAAAGCGCTGGGAATCACCCTC
ATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAG
AAGATGGGTATTGACATCAGTGTGCTGATGGGAGCCAACATTGCCAATGAGGTGGCTGCA
GAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATGGAGAACGGCCTTCTCTTCAAA
GAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAA
CTCTGTGGTGCGCTTAAGAACATCGTAGCTGTGGGAGCTGGGTTCTGCGACGGCCTCCGC
TGTGGAGACAACACCAAAGCGGCCGTCATCCGCCTGGGACTCATGGAAATGATTGCTTTT
GCCAGGATCTTCTGCAAAGGCCAAGTGTCTACAGCCACCTTCCTAGAGAGCTGCGGGGTG
GCCGACCTGATCACCACCTGTTACGGAGGGCGGAACCGCAGGGTGGCCGAGGCCTTCGCC
AGAACTGGGAAGACCATTGAAGAGTTGGAGAAGGAGATGCTGAATGGGCAAAAGCTCCAA
GGACCGCAGACTTCTGCTGAAGTGTACCGCATCCTCAAACAGAAGGGACTACTGGACAAG
TTTCCATTGTTTACTGCAGTGTATCAGATCTGCTACGAAAGCAGACCAGTTCAAGAGATG
TTGTCTTGTCTTCAGAGCCATCCAGAGCATACATAA
Protein Properties
Number of Residues 351
Molecular Weight 38418.44
Theoretical pI 7.023
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Glycerol-3-phosphate dehydrogenase 1-like protein
MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDH
ENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITL
IKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK
ELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF
ARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQ
GPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT
GenBank ID Protein 158259077
UniProtKB/Swiss-Prot ID Q8N335
UniProtKB/Swiss-Prot Entry Name GPD1L_HUMAN
PDB IDs
GenBank Gene ID AK292808
GeneCard ID GPD1L
GenAtlas ID GPD1L
HGNC ID HGNC:28956
References
General References Not Available