| Identification |
|---|
| HMDB Protein ID
| CDBP00330 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nicotinamide mononucleotide adenylyltransferase 3 |
| Description
| Not Available |
| Synonyms
|
- NMN adenylyltransferase 3
- NaMN adenylyltransferase 3
- Nicotinate-nucleotide adenylyltransferase 3
- PNAT-3
- Pyridine nucleotide adenylyltransferase 3
|
| Gene Name
| NMNAT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotidyltransferase activity |
| Specific Function
| Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
|
| GO Classification
|
| Biological Process |
| NAD biosynthetic process |
| water-soluble vitamin metabolic process |
| Cellular Component |
| cytosol |
| mitochondrion |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleotidyltransferase activity |
| Molecular Function |
| nicotinate-nucleotide adenylyltransferase activity |
| ATP binding |
| nicotinamide-nucleotide adenylyltransferase activity |
| Process |
| metabolic process |
| coenzyme biosynthetic process |
| pyridine nucleotide biosynthetic process |
| nicotinamide nucleotide biosynthetic process |
| nad biosynthetic process |
| cellular metabolic process |
| biosynthetic process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | NAD(+) biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q23 |
| SNPs
| NMNAT3 |
| Gene Sequence
|
>759 bp
ATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAAC
ATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGGAATGTACCAG
GTCATCCAGGGTATCATCTCTCCTGTCAACGACACCTATGGGAAGAAAGACCTCGCAGCT
TCTCATCACCGAGTGGCCATGGCCCGGCTGGCCCTGCAGACATCCGACTGGATCCGGGTG
GACCCTTGGGAGAGTGAGCAGGCACAGTGGATGGAGACAGTGAAGGTGCTGAGGCATCAT
CACAGCAAACTGCTCAGATCTCCACCCCAGATGGAAGGCCCAGACCATGGCAAGGCACTC
TTCTCGACCCCTGCAGCTGTGCCTGAGCTGAAGCTTCTCTGTGGGGCAGACGTCTTGAAG
ACCTTCCAGACCCCCAACCTCTGGAAGGATGCGCACATCCAGGAAATAGTGGAGAAGTTT
GGCTTGGTGTGCGTGGGCCGAGTAAGTCACGACCCAAAAGGTTACATCGCAGAATCTCCC
ATCCTACGGATGCACCAGCACAACATTCACCTGGCCAAGGAGCCTGTGCAGAATGAGATC
AGTGCCACATACATCAGGCGAGCCTTGGGCCAAGGGCAGAGCGTAAAGTACCTGATTCCC
GATGCTGTCATCACGTACATCAAGGACCATGGCCTCTACACCAAGGGCAGTACCTGGAAA
GGCAAAAGCACCCAGAGCACTGAGGGCAAGACAAGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 252 |
| Molecular Weight
| 18255.08 |
| Theoretical pI
| 9.217 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide mononucleotide adenylyltransferase 3
MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAA
SHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKAL
FSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESP
ILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYTKGSTWK
GKSTQSTEGKTS
|
| External Links |
|---|
| GenBank ID Protein
| 14029540 |
| UniProtKB/Swiss-Prot ID
| Q96T66 |
| UniProtKB/Swiss-Prot Entry Name
| NMNA3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF345564 |
| GeneCard ID
| NMNAT3 |
| GenAtlas ID
| NMNAT3 |
| HGNC ID
| HGNC:20989 |
| References |
|---|
| General References
| Not Available |