| Identification |
|---|
| HMDB Protein ID
| CDBP04093 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD-dependent protein deacetylase sirtuin-7 |
| Description
| Not Available |
| Synonyms
|
- SIR2-like protein 7
- Regulatory protein SIR2 homolog 7
|
| Gene Name
| SIRT7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
|
| GO Classification
|
| Biological Process |
| rRNA transcription |
| histone H3 deacetylation |
| positive regulation of transcription on exit from mitosis |
| negative regulation of transcription from RNA polymerase II promoter |
| Cellular Component |
| nucleolus organizer region |
| cytoplasm |
| Function |
| nad or nadh binding |
| nad binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| Molecular Function |
| NAD-dependent histone deacetylase activity (H3-K18 specific) |
| metal ion binding |
| chromatin binding |
| NAD+ binding |
| Process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid deacetylation |
| gene silencing |
| chromatin silencing |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q25 |
| SNPs
| SIRT7 |
| Gene Sequence
|
>1203 bp
ATGGCAGCCGGGGGTCTGAGCCGCTCCGAGCGCAAAGCGGCGGAGCGGGTCCGGAGGTTG
CGGGAGGAGCAGCAGAGGGAGCGCCTCCGCCAGGTGTCGCGCATCCTGAGGAAGGCGGCG
GCGGAGCGCAGCGCCGAGGAGGGCCGGCTGCTGGCCGAGAGCGCGGACCTGGTAACGGAG
CTGCAGGGCCGGAGCCGGCGGCGCGAGGGCCTGAAGCGGCGGCAGGAGGAGGTGTGCGAC
GACCCGGAGGAGCTGCGGGGGAAGGTCCGGGAGCTGGCCAGCGCCGTCCGGAACGCCAAA
TACTTGGTCGTCTACACAGGCGCGGGAATCAGCACGGCAGCGTCTATCCCAGACTACCGG
GGCCCTAATGGAGTGTGGACACTGCTTCAGAAAGGGAGAAGCGTTAGTGCTGCCGACCTG
AGCGAGGCCGAGCCAACCCTCACCCACATGAGCATCACCCGTCTGCATGAGCAGAAGCTG
GTGCAGCATGTGGTGTCTCAGAACTGTGACGGGCTCCACCTGAGGAGTGGGCTGCCGCGC
ACGGCCATCTCCGAGCTCCACGGGAACATGTACATTGAAGTCTGTACCTCCTGCGTTCCC
AACAGGGAGTACGTGCGGGTGTTCGATGTGACGGAGCGCACTGCCCTCCACAGACACCAG
ACAGGCCGGACCTGCCACAAGTGTGGGACCCAGCTGCGGGACACCATTGTGCACTTTGGG
GAGAGGGGGACGTTGGGGCAGCCTCTGAACTGGGAAGCGGCGACCGAGGCTGCCAGCAGA
GCAGACACCATCCTGTGTCTAGGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACGCCTC
TGGTGCATGACCAAGCCCCCTAGCCGGCGGCCGAAGCTTTACATCGTGAACCTGCAGTGG
ACCCCGAAGGATGACTGGGCTGCCCTGAAGCTACATGGGAAGTGTGATGACGTCATGCGG
CTCCTCATGGCCGAGCTGGGCTTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCCCATT
TTCTCACTGGCGACTCCCCTGCGTGCTGGTGAAGAAGGCAGCCACAGTCGGAAGTCGCTG
TGCAGAAGCAGAGAGGAGGCCCCGCCTGGGGACCGGGGTGCACCGCTTAGCTCGGCCCCC
ATCCTAGGGGGCTGGTTTGGCAGGGGCTGCACAAAACGCACAAAAAGGAAGAAAGTGACG
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 400 |
| Molecular Weight
| 44897.945 |
| Theoretical pI
| 9.744 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-7
MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTE
LQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYR
GPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPR
TAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFG
ERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQW
TPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSL
CRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT
|
| External Links |
|---|
| GenBank ID Protein
| 7243747 |
| UniProtKB/Swiss-Prot ID
| Q9NRC8 |
| UniProtKB/Swiss-Prot Entry Name
| SIRT7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF233395 |
| GeneCard ID
| SIRT7 |
| GenAtlas ID
| SIRT7 |
| HGNC ID
| HGNC:14935 |
| References |
|---|
| General References
| Not Available |