| Identification |
|---|
| HMDB Protein ID
| CDBP04090 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- SIR2-like protein 3
- hSIRT3
- Regulatory protein SIR2 homolog 3
|
| Gene Name
| SIRT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
|
| GO Classification
|
| Biological Process |
| protein ADP-ribosylation |
| aerobic respiration |
| peptidyl-lysine deacetylation |
| Cellular Component |
| mitochondrial matrix |
| mitochondrion |
| membrane |
| Function |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| nad or nadh binding |
| nad binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Molecular Function |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| metal ion binding |
| NAD+ ADP-ribosyltransferase activity |
| zinc ion binding |
| NAD+ binding |
| Process |
| protein amino acid deacetylation |
| gene silencing |
| chromatin silencing |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.5 |
| SNPs
| SIRT3 |
| Gene Sequence
|
>1200 bp
ATGGCGTTCTGGGGTTGGCGCGCCGCGGCAGCCCTCCGGCTGTGGGGCCGGGTAGTTGAA
CGGGTCGAGGCCGGGGGAGGCGTGGGGCCGTTTCAGGCCTGCGGCTGTCGGCTGGTGCTT
GGCGGCAGGGACGATGTGAGTGCGGGGCTGAGAGGCAGCCATGGGGCCCGCGGTGAGCCC
TTGGACCCGGCGCGCCCCTTGCAGAGGCCTCCCAGACCCGAGGTGCCCAGGGCATTCCGG
AGGCAGCCGAGGGCAGCAGCTCCCAGTTTCTTCTTTTCGAGTATTAAAGGTGGAAGAAGG
TCCATATCTTTTTCTGTGGGTGCTTCAAGTGTTGTTGGAAGTGGAGGCAGCAGTGACAAG
GGGAAGCTTTCCCTGCAGGATGTAGCTGAGCTGATTCGGGCCAGAGCCTGCCAGAGGGTG
GTGGTCATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATTCCAGACTTCAGATCGCCG
GGGAGTGGCCTGTACAGCAACCTCCAGCAGTACGATCTCCCGTACCCCGAGGCCATTTTT
GAACTCCCATTCTTCTTTCACAACCCCAAGCCCTTTTTCACTTTGGCCAAGGAGCTGTAC
CCTGGAAACTACAAGCCCAACGTCACTCACTACTTTCTCCGGCTGCTTCATGACAAGGGG
CTGCTTCTGCGGCTCTACACGCAGAACATCGATGGGCTTGAGAGAGTGTCGGGCATCCCT
GCCTCAAAGCTGGTTGAAGCTCATGGAACCTTTGCCTCTGCCACCTGCACAGTCTGCCAA
AGACCCTTCCCAGGGGAGGACATTCGGGCTGACGTGATGGCAGACAGGGTTCCCCGCTGC
CCGGTCTGCACCGGCGTTGTGAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAG
AGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGCTCATCCTTGGGACC
TCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGA
CTGCTCATCAACCGGGACTTGGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTG
GCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGCTTCTGGGCTGGACA
GAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 399 |
| Molecular Weight
| 28566.64 |
| Theoretical pI
| 5.802 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-3, mitochondrial
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
|
| External Links |
|---|
| GenBank ID Protein
| 5225322 |
| UniProtKB/Swiss-Prot ID
| Q9NTG7 |
| UniProtKB/Swiss-Prot Entry Name
| SIRT3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF083108 |
| GeneCard ID
| SIRT3 |
| GenAtlas ID
| SIRT3 |
| HGNC ID
| HGNC:14931 |
| References |
|---|
| General References
| Not Available |