| Identification |
|---|
| HMDB Protein ID
| CDBP00297 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pyrroline-5-carboxylate reductase 1, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- P5C reductase 1
- P5CR 1
|
| Gene Name
| PYCR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
|
| GO Classification
|
| Biological Process |
| proline biosynthetic process |
| cellular nitrogen compound metabolic process |
| L-proline biosynthetic process |
| cellular response to oxidative stress |
| Cellular Component |
| mitochondrial matrix |
| Function |
| binding |
| catalytic activity |
| pyrroline-5-carboxylate reductase activity |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor |
| oxidoreductase activity |
| Molecular Function |
| pyrroline-5-carboxylate reductase activity |
| nucleotide binding |
| Process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| metabolic process |
| cellular metabolic process |
| glutamine family amino acid metabolic process |
| proline metabolic process |
| proline biosynthetic process |
| oxidation reduction |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-proline biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q25.3 |
| SNPs
| PYCR1 |
| Gene Sequence
|
>960 bp
ATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACA
GCAGCAGGCGTCTTGGCTGCCCACAAGATAATGGCTAGCTCCCCAGACATGGACCTGGCC
ACAGTTTCTGCTCTCAGGAAGATGGGGGTGAAGTTGACACCCCACAACAAGGAGACGGTG
CAGCACAGTGATGTGCTCTTCCTGGCTGTGAAGCCACACATCATCCCCTTCATCCTGGAT
GAAATAGGCGCCGACATTGAGGACAGACACATTGTGGTGTCCTGCGCGGCCGGCGTCACC
ATCAGCTCCATTGAGAAGAAGCTGTCAGCGTTTCGGCCAGCCCCCAGGGTCATCCGCTGC
ATGACCAACACTCCAGTCGTGGTGCGGGAGGGGGCCACCGTGTATGCCACAGGCACGCAC
GCCCAGGTGGAGGACGGGAGGCTCATGGAGCAGCTGCTGAGCAGCGTGGGCTTCTGCACG
GAGGTGGAAGAGGACCTGATTGATGCCGTCACGGGGCTCAGTGGCAGCGGCCCCGCCTAC
GCATTCACAGCCCTGGATGCCCTGGCTGATGGGGGCGTGAAGATGGGACTTCCAAGGCGC
CTGGCAGTCCGCCTCGGGGCCCAGGCCCTCCTGGGGGCTGCCAAGATGCTGCTGCACTCA
GAACAGCACCCAGGCCAGCTCAAGGACAACGTCAGCTCTCCTGGTGGGGCCACCATCCAT
GCCTTGCATGTGCTGGAGAGTGGGGGCTTCCGCTCCCTGCTCATCAACGCTGTGGAGGCC
TCCTGCATCCGCACACGGGAGCTGCAGTCCATGGCTGACCAGGAGCAGGTGTCACCAGCC
GCCATCAAGAAGACCATCCTGGACAAGGTGAAGCTGGACTCCCCTGCAGGGACCGCTCTG
TCGCCTTCTGGCCACACCAAGCTGCTCCCCCGCAGCCTGGCCCCAGCGGGCAAGGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 319 |
| Molecular Weight
| 33360.27 |
| Theoretical pI
| 7.606 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyrroline-5-carboxylate reductase 1, mitochondrial
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD
|
| External Links |
|---|
| GenBank ID Protein
| 16306658 |
| UniProtKB/Swiss-Prot ID
| P32322 |
| UniProtKB/Swiss-Prot Entry Name
| P5CR1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC001504 |
| GeneCard ID
| PYCR1 |
| GenAtlas ID
| PYCR1 |
| HGNC ID
| HGNC:9721 |
| References |
|---|
| General References
| Not Available |