| Identification |
|---|
| HMDB Protein ID
| CDBP00012 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pyruvate dehydrogenase E1 component subunit beta, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- PDHE1-B
|
| Gene Name
| PDHB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
|
| GO Classification
|
| Biological Process |
| acetyl-CoA biosynthetic process from pyruvate |
| regulation of acetyl-CoA biosynthetic process from pyruvate |
| glycolysis |
| tricarboxylic acid cycle |
| Cellular Component |
| mitochondrial matrix |
| pyruvate dehydrogenase complex |
| Function |
| catalytic activity |
| Molecular Function |
| pyruvate dehydrogenase (acetyl-transferring) activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Citric Acid Cycle |    |  | | Pyruvate Metabolism |    |  | | Transfer of Acetyl Groups into Mitochondria |    | Not Available | | Glycolysis / Gluconeogenesis | Not Available |  | | Citrate cycle (TCA cycle) | Not Available | |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p21.1-p14.2 |
| SNPs
| PDHB |
| Gene Sequence
|
>1080 bp
ATGGCGGCGGTGTCTGGCTTGGTGCGGAGACCCCTTCGGGAGGTCTCCGGGCTGCTGAAG
AGGCGCTTTCACTGGACCGCGCCGGCTGCGCTGCAGGTGACAGTTCGTGATGCTATAAAT
CAGGGTATGGATGAGGAGCTGGAAAGAGATGAGAAGGTATTTCTGCTTGGAGAAGAAGTT
GCCCAGTATGATGGGGCATACAAGGTTAGTCGAGGGCTGTGGAAGAAATATGGAGACAAG
AGGATTATTGACACTCCCATATCAGAGATGGGCTTTGCTGGAATTGCTGTAGGTGCAGCT
ATGGCTGGGTTGCGGCCCATTTGTGAATTTATGACCTTCAATTTCTCCATGCAAGCCATT
GACCAGGTTATAAACTCAGCTGCCAAGACCTACTACATGTCTGGTGGCCTTCAGCCTGTG
CCTATAGTCTTCAGGGGGCCCAATGGTGCCTCAGCAGGTGTAGCTGCCCAGCACTCACAG
TGCTTTGCTGCCTGGTATGGGCACTGCCCAGGCTTAAAGGTGGTCAGTCCCTGGAATTCA
GAGGATGCTAAAGGACTTATTAAATCAGCCATTCGGGATAACAATCCAGTGGTGGTGCTA
GAGAATGAATTGATGTATGGGGTTCCTTTTGAATTTCCTCCGGAAGCTCAGTCAAAAGAT
TTTCTGATTCCTATTGGAAAAGCCAAAATAGAAAGGCAAGGAACACATATAACTGTGGTT
TCCCATTCAAGACCTGTGGGCCACTGCTTAGAAGCTGCAGCAGTGCTATCTAAAGAAGGA
GTTGAATGTGAGGTGATAAATATGCGTACCATTAGACCAATGGACATGGAAACCATAGAA
GCCAGTGTCATGAAGACAAATCATCTTGTAACTGTGGAAGGAGGCTGGCCACAGTTTGGA
GTAGGAGCTGAAATCTGTGCCAGGATCATGGAAGGTCCTGCGTTCAATTTCCTGGATGCT
CCTGCTGTTCGTGTCACTGGTGCTGATGTCCCTATGCCTTATGCAAAGATTCTAGAGGAC
AACTCTATACCTCAGGTCAAAGACATCATATTTGCAATAAAGAAAACATTAAATATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 359 |
| Molecular Weight
| 39233.1 |
| Theoretical pI
| 6.647 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV
SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
|
| External Links |
|---|
| GenBank ID Protein
| 189053605 |
| UniProtKB/Swiss-Prot ID
| P11177 |
| UniProtKB/Swiss-Prot Entry Name
| ODPB_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK313022 |
| GeneCard ID
| PDHB |
| GenAtlas ID
| PDHB |
| HGNC ID
| HGNC:8808 |
| References |
|---|
| General References
| Not Available |