Cannabis Compound Database: Showing Compound Card for Pyrophosphate (CDB005103)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (322)transporters (3) Show 566 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:09:37 UTC

Updated at

2020-12-07 19:11:35 UTC

CannabisDB ID

CDB005103

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Pyrophosphate

Description

Pyrophosphate, also known as diphosphorsaeure or H4P2O7, belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion. Pyrophosphate is a moderately acidic compound (based on its pKa). Pyrophosphate exists in all living species, ranging from bacteria to humans. In humans, pyrophosphate is involved in intracellular signalling through PGD2 receptor and prostaglandin D2. Pyrophosphate is a potentially toxic compound. An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid. Pyrophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
[(HO)2P(O)OP(O)(OH)2]	ChEBI
Acide diphosphorique	ChEBI
Diphosphorsaeure	ChEBI
H4P2O7	ChEBI
Pyrophosphoric acid	ChEBI
Pyrophosphorsaeure	ChEBI
Diphosphoric acid	Kegg
PPi	Kegg
Diphosphate	Generator
PYROphosphATE	ChEBI
Na4p2O7	MeSH, HMDB
PPi CPD	MeSH, HMDB

Chemical Formula

H₄O₇P₂

Average Molecular Weight

177.98

Monoisotopic Molecular Weight

177.9432

IUPAC Name

(phosphonooxy)phosphonic acid

Traditional Name

pyrophosphoric acid

CAS Registry Number

33943-49-6

SMILES

OP(O)(=O)OP(O)(O)=O

InChI Identifier

InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)

InChI Key

XPPKVPWEQAFLFU-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion.

Kingdom

Inorganic compounds

Super Class

Homogeneous non-metal compounds

Class

Non-metal oxoanionic compounds

Sub Class

Non-metal pyrophosphates

Direct Parent

Non-metal pyrophosphates

Alternative Parents

Inorganic oxides

Substituents

Non-metal pyrophosphate
Inorganic oxide

Molecular Framework

Not Available

External Descriptors

phosphorus oxoacid (CHEBI:29888 )
acyclic phosphorus acid anhydride (CHEBI:29888 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Role

Indirect biological role:

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	61 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.4	ChemAxon
pKa (Strongest Acidic)	1.7	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	124.29 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	25.52 m³·mol⁻¹	ChemAxon
Polarizability	10.28 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Pyrophosphate, non-derivatized, GC-MS Spectrum	splash10-0002-0972000000-a80f120dd426991d6eff	Spectrum
GC-MS	Pyrophosphate, non-derivatized, GC-MS Spectrum	splash10-0udi-0741900000-9c5b3c334561dd282116	Spectrum
GC-MS	Pyrophosphate, non-derivatized, GC-MS Spectrum	splash10-03di-0920000000-a5ad76aa129d898d71f8	Spectrum
GC-MS	Pyrophosphate, non-derivatized, GC-MS Spectrum	splash10-03di-0910000000-531d3e19493dc29d6e5c	Spectrum
GC-MS	Pyrophosphate, 4 TMS, GC-MS Spectrum	splash10-0udi-0320900000-0abbcb28a43d7e24fe81	Spectrum
GC-MS	Pyrophosphate, non-derivatized, GC-MS Spectrum	splash10-0udi-0320900000-0abbcb28a43d7e24fe81	Spectrum
Predicted GC-MS	Pyrophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9200000000-47d5c2340766aaf36e95	Spectrum
Predicted GC-MS	Pyrophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-004j-5900000000-6633d5123eb37c266247	2018-05-17	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0002-9000000000-1274b83242b279e9dac7	2018-05-17	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001i-9000000000-69bc4c795fec87fef4b8	2018-05-17	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 1V, negative	splash10-0udi-0009000000-0d7e21d878a866bb58ce	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 2V, negative	splash10-0a4i-0009000000-886725ef1e6e856bba4e	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 3V, negative	splash10-0udi-0009000000-6ea52df356fc0219aae7	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 4V, negative	splash10-0udi-0009000000-bb05c17fd2d302e48d47	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 5V, negative	splash10-0udi-0109000000-884206603f4eb302c100	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 6V, negative	splash10-0udi-0109000000-f6479c3c70cf1da434a7	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 7V, negative	splash10-0udi-0219000000-8c9d253d3347c2b2a7b1	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 8V, negative	splash10-0ufr-0529000000-40db63b6f9bc6df64259	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 9V, negative	splash10-0a6r-0938000000-128abea42399dbbd6b73	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 10V, negative	splash10-004i-0923000000-bf96528807a30d13e941	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 11V, negative	splash10-004i-0922000000-7ba3aaba52e7bda31d59	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 12V, negative	splash10-004i-0911000000-729a221aabae27701a80	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 13V, negative	splash10-004i-0910000000-2fc64e199062885202b2	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 14V, negative	splash10-004i-0910000000-0d1641e2522b985110a8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 15V, negative	splash10-004i-0910000000-fca1eea6589ac6828b32	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 16V, negative	splash10-004i-0900000000-6fae5d4a6887e1ace201	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-004j-4900000000-fab623ebd43ab1452b9f	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-9400000000-b2565f0d436385569cff	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000t-9300000000-ac978f84efc222da7b43	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0900000000-21c64963e1ff18b360e1	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9700000000-54e41043f009fe6db86c	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-2a5f69c16aa671275a62	2015-09-15	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Alanine Metabolism
Primary Hyperoxaluria Type I		Not Available
Pyruvate Carboxylase Deficiency		Not Available
Lactic Acidemia		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	20q11.22	Q9NR19	details
Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	20p11.23-p11.21	Q9NUB1	details
Serum paraoxonase/lactonase 3	PON3	7q21.3	Q15166	details
Fucose-1-phosphate guanylyltransferase	FPGT	1p31.1	O14772	details
Squalene synthase	FDFT1	8p23.1-p22	P37268	details
Phenylalanine--tRNA ligase alpha subunit	FARSA	19p13.2	Q9Y285	details
Phenylalanine--tRNA ligase, mitochondrial	FARS2	6p25.1	O95363	details
Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	5q31	P49419	details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	1p36.22	Q9HAN9	details
Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	3q23	Q96T66	details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	16p11.2	Q15274	details
Nicotinamide mononucleotide adenylyltransferase 2	NMNAT2	1q25	Q9BZQ4	details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	PAPSS1	4q24	O43252	details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	PAPSS2	10q24	O95340	details
N-acylneuraminate cytidylyltransferase	CMAS	12p12.1	Q8NFW8	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	DUT	15q21.1	P33316	details
Adenine phosphoribosyltransferase	APRT	16q24	P07741	details
Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	Xq26.1	P00492	details
Biotin--protein ligase	HLCS	21q22.13	P50747	details
Phenylalanine--tRNA ligase beta subunit	FARSB	2q36.1	Q9NSD9	details
Ubiquitin-conjugating enzyme E2 A	UBE2A	Xq24	P49459	details
NEDD8-conjugating enzyme Ubc12	UBE2M	19q13.43	P61081	details
Ubiquitin/ISG15-conjugating enzyme E2 L6	UBE2L6	11q12	O14933	details
Glycine--tRNA ligase	GARS	7p15	P41250	details
Bifunctional glutamate/proline--tRNA ligase	EPRS	1q41	P07814	details
Long-chain-fatty-acid--CoA ligase 4	ACSL4	Xq22.3-q23	O60488	details
Tryptophan--tRNA ligase, cytoplasmic	WARS	14q32.31	P23381	details
Long-chain-fatty-acid--CoA ligase 1	ACSL1	4q35	P33121	details
Ubiquitin-conjugating enzyme E2 G1	UBE2G1	17p13.2	P62253	details
Glutamine--tRNA ligase	QARS	3p21.31	P47897	details
Threonine--tRNA ligase, cytoplasmic	TARS	5p13.2	P26639	details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
Ubiquitin-conjugating enzyme E2 E2	UBE2E2	3p24.2	Q96LR5	details
Ubiquitin-conjugating enzyme E2 D2	UBE2D2	5q31.2	P62837	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
Arginine--tRNA ligase, cytoplasmic	RARS	5q35.1	P54136	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
Ubiquitin-conjugating enzyme E2 B	UBE2B	5q31.1	P63146	details
Probable leucine--tRNA ligase, mitochondrial	LARS2	3p21.3	Q15031	details
Ubiquitin-conjugating enzyme E2 J2	UBE2J2	1p36.33	Q8N2K1	details
Ubiquitin-conjugating enzyme E2 L3	UBE2L3	22q11.21	P68036	details
RNA 3'-terminal phosphate cyclase	RTCA	1p21.2	O00442	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
DNA ligase 3	LIG3	17q11.2-q12	P49916	details
Aspartate--tRNA ligase, cytoplasmic	DARS	2q21.3	P14868	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
Asparagine--tRNA ligase, cytoplasmic	NARS	18q21.31	O43776	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
Isoleucine--tRNA ligase, cytoplasmic	IARS	9q21	P41252	details
Ubiquitin-like modifier-activating enzyme 1	UBA1		P22314	details
Tyrosine--tRNA ligase, mitochondrial	YARS2	12p11.21	Q9Y2Z4	details
Ubiquitin-conjugating enzyme E2 E1	UBE2E1	3p24.2	P51965	details
Long-chain-fatty-acid--CoA ligase 6	ACSL6	5q31	Q9UKU0	details
Methionine--tRNA ligase, cytoplasmic	MARS	12q13	P56192	details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Tryptophan--tRNA ligase, mitochondrial	WARS2	1p12	Q9UGM6	details
Ribose-phosphate pyrophosphokinase 1	PRPS1	Xq21.32-q24	P60891	details
Serine--tRNA ligase, mitochondrial	SARS2	19q13.2	Q9NP81	details
Ribose-phosphate pyrophosphokinase 2	PRPS2	Xp22.2	P11908	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
Probable histidine--tRNA ligase, mitochondrial	HARS2	5q31.3	P49590	details
Ubiquitin-conjugating enzyme E2 J1	UBE2J1	6q15	Q9Y385	details
Long-chain-fatty-acid--CoA ligase 5	ACSL5	10q25.1-q25.2	Q9ULC5	details
Histidine--tRNA ligase, cytoplasmic	HARS	5q31.3	P12081	details
Serine--tRNA ligase, cytoplasmic	SARS	1p13.3	P49591	details
Long-chain-fatty-acid--CoA ligase 3	ACSL3	2q34-q35	O95573	details
Leucine--tRNA ligase, cytoplasmic	LARS	5q32	Q9P2J5	details
Ubiquitin-conjugating enzyme E2 C	UBE2C	20q13.12	O00762	details
Valine--tRNA ligase	VARS	6p21.3	P26640	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
Argininosuccinate synthase	ASS1	9q34.1	P00966	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Choline-phosphate cytidylyltransferase B	PCYT1B	Xp22.11	Q9Y5K3	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
Ethanolamine-phosphate cytidylyltransferase	PCYT2	17q25.3	Q99447	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
Phosphatidate cytidylyltransferase 2	CDS2	20p13	O95674	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
Choline-phosphate cytidylyltransferase A	PCYT1A	3q29	P49585	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
Phosphatidate cytidylyltransferase 1	CDS1	4q21.23	Q92903	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Geranylgeranyl pyrophosphate synthase	GGPS1	1q43	O95749	details
Farnesyl pyrophosphate synthase	FDPS	1q22	P14324	details
DNA polymerase beta	POLB	8p11.2	P06746	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase lambda	POLL	10q23	Q9UGP5	details
DNA polymerase epsilon subunit 4	POLE4	2p12	Q9NR33	details
DNA polymerase eta	POLH	6p21.1	Q9Y253	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase zeta catalytic subunit	REV3L	6q21	O60673	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA-directed DNA/RNA polymerase mu	POLM	7p13	Q9NP87	details
DNA polymerase kappa	POLK	5q13	Q9UBT6	details
DNA polymerase epsilon subunit 3	POLE3	9q33	Q9NRF9	details
DNA polymerase subunit gamma-1	POLG	15q25	P54098	details
DNA polymerase iota	POLI	18q21.1	Q9UNA4	details
DNA polymerase epsilon subunit 2	POLE2	14q21-q22	P56282	details
Uridine 5'-monophosphate synthase	UMPS	3q13	P11172	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Retinal guanylyl cyclase 1	GUCY2D	17p13.1	Q02846	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Inorganic pyrophosphatase	PPA1	10q11.1-q24	Q15181	details
Guanylate cyclase soluble subunit alpha-2	GUCY1A2	11q21-q22	P33402	details
UTP--glucose-1-phosphate uridylyltransferase	UGP2	2p14-p13	Q16851	details
DNA nucleotidylexotransferase	DNTT	10q23-q24	P04053	details
Retinal guanylyl cyclase 2	GUCY2F	Xq22	P51841	details
Guanylate cyclase soluble subunit beta-2	GUCY1B2		O75343	details
Poly(A) polymerase alpha	PAPOLA	14q32.31	P51003	details
UDP-N-acetylhexosamine pyrophosphorylase	UAP1	1q23.3	Q16222	details
Poly(A) polymerase gamma	PAPOLG	2p16.1	Q9BWT3	details
Protoheme IX farnesyltransferase, mitochondrial	COX10		Q12887	details
Geranylgeranyl transferase type-1 subunit beta	PGGT1B	5q22.3	P53609	details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	FNTA	8p11	P49354	details
Bifunctional coenzyme A synthase	COASY	17q12-q21	Q13057	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Adenylyltransferase and sulfurtransferase MOCS3	MOCS3	20q13.13	O95396	details
E3 ubiquitin-protein ligase NEDD4-like	NEDD4L	18q21	Q96PU5	details
E3 ubiquitin-protein ligase Mdm2	MDM2	12q14.3-q15	Q00987	details
Telomerase reverse transcriptase	TERT	5p15.33	O14746	details
7,8-dihydro-8-oxoguanine triphosphatase	NUDT1	7p22	P36639	details
Phosphopantothenate--cysteine ligase	PPCS	1p34.2	Q9HAB8	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Glutamine-dependent NAD(+) synthetase	NADSYN1	11q13.4	Q6IA69	details
4-hydroxybenzoate polyprenyltransferase, mitochondrial	COQ2	4q21.23	Q96H96	details
Mannose-1-phosphate guanyltransferase beta	GMPPB	3p21.31	Q9Y5P6	details
Mannose-1-phosphate guanyltransferase alpha	GMPPA	2q35	Q96IJ6	details
Methionine adenosyltransferase 2 subunit beta	MAT2B		Q9NZL9	details
Acetoacetyl-CoA synthetase	AACS	12q24.31	Q86V21	details
Adenylate cyclase type 10	ADCY10	1q24	Q96PN6	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Inorganic pyrophosphatase 2, mitochondrial	PPA2	4q25	Q9H2U2	details
Probable arginine--tRNA ligase, mitochondrial	RARS2	6q16.1	Q5T160	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
Probable glutamate--tRNA ligase, mitochondrial	EARS2	16p12.2	Q5JPH6	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details
ACSS2 protein	ACSS2	20q11.22	Q96FY7	details
FAD synthase	FLAD1	1q21.3	Q8NFF5	details
Valine--tRNA ligase, mitochondrial	VARS2	6p21.33	Q5ST30	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Probable E3 ubiquitin-protein ligase HERC1	HERC1	15q22	Q15751	details
E3 ubiquitin-protein ligase HERC2	HERC2	15q13	O95714	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Probable 8-oxo-dGTP diphosphatase NUDT15	NUDT15	13q14.2	Q9NV35	details
CCA tRNA nucleotidyltransferase 1, mitochondrial	TRNT1	3p25.1	Q96Q11	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
Nicotinate phosphoribosyltransferase	NAPRT1	8q24.3	Q6XQN6	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Probable threonine--tRNA ligase 2, cytoplasmic	TARSL2	15q26.3	A2RTX5	details
Threonine--tRNA ligase, mitochondrial	TARS2	1q21.3	Q9BW92	details
Methionine--tRNA ligase, mitochondrial	MARS2	2q33.1	Q96GW9	details
Aspartate--tRNA ligase, mitochondrial	DARS2	1q25.1	Q6PI48	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
FARSLA protein	FARSLA		Q6IBR2	details
Probable asparagine--tRNA ligase, mitochondrial	NARS2	11q14.1	Q96I59	details
SUMO-activating enzyme subunit 2	UBA2	19q12	Q9UBT2	details
E3 ubiquitin-protein ligase HUWE1	HUWE1		Q7Z6Z7	details
E3 ubiquitin-protein ligase Topors	TOPORS	9p21	Q9NS56	details
STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)	STUB1	16p13.3	Q9UNE7	details
Ubiquitin conjugation factor E4 B	UBE4B	1p36.3	O95155	details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)	MARCH6		O60337	details
TGIF-interacting ubiquitin ligase 1			Q9H0M0	details
NEDD4-like E3 ubiquitin-protein ligase WWP2	WWP2	16q22.1	O00308	details
E3 ubiquitin-protein ligase MARCH3	MARCH3	5q23.2	Q86UD3	details
NEDD8-conjugating enzyme UBE2F	UBE2F	2q37.3	Q969M7	details
Ubiquitin-conjugating enzyme E2 U	UBE2U	1p31.3	Q5VVX9	details
Probable E3 ubiquitin-protein ligase MARCH10	MARCH10	17q23.2	Q8NA82	details
E3 ubiquitin-protein ligase UBR1	UBR1	15q13	Q8IWV7	details
E3 ubiquitin-protein ligase MARCH8	MARCH8	10q11.21	Q5T0T0	details
E3 ubiquitin-protein ligase ZNRF2	ZNRF2	7p14.3	Q8NHG8	details
E3 ubiquitin-protein ligase TRIM32	TRIM32	9q33.1	Q13049	details
Probable E3 ubiquitin-protein ligase MYCBP2	MYCBP2	13q22	O75592	details
E3 ubiquitin-protein ligase MGRN1	MGRN1	16p13.3	O60291	details
E3 ubiquitin-protein ligase UBR2	UBR2	6p21.1	Q8IWV8	details
E3 ubiquitin-protein ligase UBR4	UBR4	1p36.13	Q5T4S7	details
E3 ubiquitin-protein ligase AMFR	AMFR	16q21	Q9UKV5	details
Ubiquitin-conjugating enzyme E2 S	UBE2S	19q13.43	Q16763	details
Pre-mRNA-processing factor 19	PRPF19	11q12.2	Q9UMS4	details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)	MYLIP		Q8WY64	details
HNP95	hNp95		Q96T88	details
Putative ubiquitin-conjugating enzyme E2 N-like	UBE2NL		Q5JXB2	details
Midline-1	MID1		O15344	details
E3 ubiquitin-protein ligase NEDD4	NEDD4	15q	P46934	details
CCR4-NOT transcription complex subunit 4	CNOT4	7q22-qter	O95628	details
E3 ubiquitin-protein ligase MARCH2	MARCH2	19p13.2	Q9P0N8	details
E3 ubiquitin-protein ligase UBR5	UBR5	8q22	O95071	details
E3 ubiquitin-protein ligase TRIM33	TRIM33	1p13.1	Q9UPN9	details
E3 ubiquitin-protein ligase MARCH5	MARCH5	10q23.32-q23.33	Q9NX47	details
Ubiquitin-conjugating enzyme E2 R2	UBE2R2	9p13.3	Q712K3	details
E3 ubiquitin-protein ligase MARCH1	MARCH1	4q32.2	Q8TCQ1	details
E3 ubiquitin-protein ligase FANCL	FANCL	2p16.1	Q9NW38	details
Ubiquitin-like modifier-activating enzyme 6	UBA6	4q13.2	A0AVT1	details
Ubiquitin-conjugating enzyme E2 W	UBE2W	8q21.11	Q96B02	details
Galactosyl transferase-associated protein	GTAP		Q29SN7	details
E3 ubiquitin-protein ligase CHFR	CHFR	12q24.33	Q96EP1	details
Ring finger protein 20	RNF20		Q5VTR2	details
E3 ubiquitin-protein ligase RAD18	RAD18	3p25-p24	Q9NS91	details
E3 ubiquitin ligase SMURF1	SMURF1	7q22.1	Q9HCE7	details
Baculoviral IAP repeat-containing protein 6	BIRC6	2p22.3	Q9NR09	details
E3 ubiquitin-protein ligase MARCH4	MARCH4	2q35	Q9P2E8	details
E3 ubiquitin-protein ligase CCNB1IP1	CCNB1IP1	14q11.2	Q9NPC3	details
E3 ubiquitin-protein ligase RNF5	RNF5	6p21.3	Q99942	details
Ubiquitin-conjugating enzyme E2 O	UBE2O	17q25.1	Q9C0C9	details
Praja 1	PJA1		A2A322	details
RFWD2 protein	RFWD2	1q25.1-q25.2	Q05CT6	details
E3 ubiquitin-protein ligase SMURF2	SMURF2	17q22-q23	Q9HAU4	details
E3 ubiquitin-protein ligase SIAH1	SIAH1	16q12	Q8IUQ4	details
E3 ubiquitin-protein ligase SIAH2	SIAH2	3q25	O43255	details
E3 ubiquitin-protein ligase MARCH7	MARCH7	2q24.2	Q9H992	details
Ubiquitin-conjugating enzyme E2 Z	UBE2Z	17q21.32	Q9H832	details
Ubiquitin-like modifier-activating enzyme 7	UBA7	3p21	P41226	details
Ubiquitin carrier protein	UBE2H	7q32	A4D1L5	details
Ubiquitin-protein ligase E3A	UBE3A	15q11.2	Q05086	details
E3 ubiquitin-protein ligase RNF128	RNF128		Q8TEB7	details
E3 ubiquitin-protein ligase TRIM11	TRIM11	1q42.13	Q96F44	details
BRCA1 associated protein variant			Q59H81	details
E3 ubiquitin-protein ligase synoviolin	SYVN1	11q13	Q86TM6	details
E3 ubiquitin-protein ligase TRIM63	TRIM63	1p34-p33	Q969Q1	details
E3 ubiquitin-protein ligase LNX	LNX1	4q12	Q8TBB1	details
E3 ubiquitin-protein ligase ZNRF1	ZNRF1	16q23.1	Q8ND25	details
Tripartite motif-containing protein 5	TRIM5	11p15	Q9C035	details
Ubiquitin-protein ligase E3B	UBE3B	12q24.11	Q7Z3V4	details
E3 ubiquitin-protein ligase RNF8	RNF8	6p21.3	O76064	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details
Ubiquitin-conjugating enzyme E2 Q2	UBE2Q2	15q24.2	Q8WVN8	details
E3 ubiquitin-protein ligase MARCH9	MARCH9	12q14.1	Q86YJ5	details
Probable E3 ubiquitin-protein ligase TRIP12	TRIP12	2q36.3	Q14669	details
E3 ubiquitin-protein ligase DZIP3	DZIP3	3q13.13	Q86Y13	details
Ubiquitin-protein ligase E3C	UBE3C	7q36.3	Q15386	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
tRNA isopentenyltransferase 1 variant	TRIT1	1p34.2	Q53F11	details
Myb-binding protein 1A	MYBBP1A	17p13.3	Q9BQG0	details
DNA polymerase theta	POLQ	3q13.33	O75417	details
Poly(A) polymerase beta (Testis specific)	PAPOLB	7p22.1	A4D1Z6	details
Protein farnesyltransferase subunit beta	FNTB	14q23.3	P49356	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
Isoleucine--tRNA ligase, mitochondrial	IARS2	1q41	Q9NSE4	details
Uracil phosphoribosyltransferase homolog	UPRT		Q96BW1	details
Probable proline--tRNA ligase, mitochondrial	PARS2	1p32.2	Q7L3T8	details
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	LHPP	10q26.13	Q9H008	details
Long-chain-fatty-acid--CoA ligase ACSBG2	ACSBG2	19p13.3	Q5FVE4	details
Long-chain-fatty-acid--CoA ligase ACSBG1	ACSBG1	15q23-q24	Q96GR2	details
E3 ubiquitin-protein ligase MIB1	MIB1	18q11.2	Q86YT6	details
E3 ubiquitin-protein ligase RNF138	RNF138	18q12.1	Q8WVD3	details
E3 ubiquitin-protein ligase RING2	RNF2	1q25.3	Q99496	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
SUMO-activating enzyme subunit 1	SAE1	19q13.32	Q9UBE0	details
Ubiquitin-conjugating enzyme E2 D4	UBE2D4	7p13	Q9Y2X8	details
Ubiquitin conjugation factor E4 A	UBE4A	11q23.3	Q14139	details
E3 ubiquitin-protein ligase RNF144B	RNF144B	6p22.3	Q7Z419	details
Acyl-CoA synthetase short-chain family member 3, mitochondrial	ACSS3	12q21.31	Q9H6R3	details
Cyclic GMP-AMP synthase	MB21D1	6q13	Q8N884	details
dCTP pyrophosphatase 1	DCTPP1	16p11.2	Q9H773	details
Decaprenyl-diphosphate synthase subunit 2	PDSS2	6q21	Q86YH6	details
DNA polymerase delta subunit 2	POLD2	7p13	P49005	details
DNA polymerase subunit gamma-2, mitochondrial	POLG2	17q	Q9UHN1	details
DNA polymerase nu	POLN	4p16.3	Q7Z5Q5	details
Decaprenyl-diphosphate synthase subunit 1	PDSS1	10p12.1	Q5T2R2	details
Adenosine monophosphate-protein transferase FICD	FICD	12q24.1	Q9BVA6	details
Poly(A) RNA polymerase GLD2	PAPD4	5q14.1	Q6PIY7	details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	HDDC3	15q26.1	Q8N4P3	details
tRNA dimethylallyltransferase, mitochondrial	TRIT1	1p34.2	Q9H3H1	details
Poly(A) RNA polymerase, mitochondrial	MTPAP	10p11.23	Q9NVV4	details
DNA polymerase sigma	PAPD7	5p15	Q5XG87	details
Poly(A) polymerase beta	PAPOLB	7p22.1	Q9NRJ5	details
Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	14q11.2	Q92696	details
Geranylgeranyl transferase type-2 subunit beta	RABGGTB	1p31	P53611	details
DNA primase small subunit	PRIM1		P49642	details
DNA primase large subunit	PRIM2		P49643	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details
tRNA-splicing ligase RtcB homolog	C22orf28	22q12	Q9Y3I0	details
Speckle targeted PIP5K1A-regulated poly(A) polymerase	TUT1	11q12.2	Q9H6E5	details
Probable tRNA(His) guanylyltransferase	THG1L	5q33.3	Q9NWX6	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details
Terminal uridylyltransferase 4	ZCCHC11	1p32.3	Q5TAX3	details
Terminal uridylyltransferase 7	ZCCHC6	9q21	Q5VYS8	details
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1	UAP1L1		Q3KQV9	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Serum paraoxonase/lactonase 3	PON3	7q21.3	Q15166	details
Phenylalanine--tRNA ligase, mitochondrial	FARS2	6p25.1	O95363	details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
Phenylalanine--tRNA ligase beta subunit	FARSB	2q36.1	Q9NSD9	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
DNA ligase 3	LIG3	17q11.2-q12	P49916	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Ribose-phosphate pyrophosphokinase 1	PRPS1	Xq21.32-q24	P60891	details
Ribose-phosphate pyrophosphokinase 2	PRPS2	Xp22.2	P11908	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Geranylgeranyl pyrophosphate synthase	GGPS1	1q43	O95749	details
Farnesyl pyrophosphate synthase	FDPS	1q22	P14324	details
DNA polymerase beta	POLB	8p11.2	P06746	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase lambda	POLL	10q23	Q9UGP5	details
DNA polymerase eta	POLH	6p21.1	Q9Y253	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase zeta catalytic subunit	REV3L	6q21	O60673	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA-directed DNA/RNA polymerase mu	POLM	7p13	Q9NP87	details
DNA polymerase kappa	POLK	5q13	Q9UBT6	details
DNA polymerase iota	POLI	18q21.1	Q9UNA4	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Inorganic pyrophosphatase	PPA1	10q11.1-q24	Q15181	details
Guanylate cyclase soluble subunit alpha-2	GUCY1A2	11q21-q22	P33402	details
UTP--glucose-1-phosphate uridylyltransferase	UGP2	2p14-p13	Q16851	details
DNA nucleotidylexotransferase	DNTT	10q23-q24	P04053	details
Guanylate cyclase soluble subunit beta-2	GUCY1B2		O75343	details
Poly(A) polymerase gamma	PAPOLG	2p16.1	Q9BWT3	details
Geranylgeranyl transferase type-1 subunit beta	PGGT1B	5q22.3	P53609	details
Adenylyltransferase and sulfurtransferase MOCS3	MOCS3	20q13.13	O95396	details
Molybdenum cofactor biosynthesis protein 1	MOCS1	6p21.3	Q9NZB8	details
E3 ubiquitin-protein ligase Mdm2	MDM2	12q14.3-q15	Q00987	details
Telomerase reverse transcriptase	TERT	5p15.33	O14746	details
Gephyrin	GPHN	14q23.3	Q9NQX3	details
7,8-dihydro-8-oxoguanine triphosphatase	NUDT1	7p22	P36639	details
Adenylate cyclase type 10	ADCY10	1q24	Q96PN6	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Inorganic pyrophosphatase 2, mitochondrial	PPA2	4q25	Q9H2U2	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Signal transduction protein CBL-C	CBLC	19q13.2	Q9ULV8	details
Protein prune homolog	PRUNE	1q21	Q86TP1	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
E3 ubiquitin-protein ligase HERC2	HERC2	15q13	O95714	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Probable 8-oxo-dGTP diphosphatase NUDT15	NUDT15	13q14.2	Q9NV35	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
E3 ubiquitin-protein ligase Topors	TOPORS	9p21	Q9NS56	details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)	MARCH6		O60337	details
E3 ubiquitin-protein ligase MARCH3	MARCH3	5q23.2	Q86UD3	details
Probable E3 ubiquitin-protein ligase MARCH10	MARCH10	17q23.2	Q8NA82	details
E3 ubiquitin-protein ligase UBR1	UBR1	15q13	Q8IWV7	details
E3 ubiquitin-protein ligase MARCH8	MARCH8	10q11.21	Q5T0T0	details
E3 ubiquitin-protein ligase ZNRF2	ZNRF2	7p14.3	Q8NHG8	details
E3 ubiquitin-protein ligase TRIM32	TRIM32	9q33.1	Q13049	details
Probable E3 ubiquitin-protein ligase MYCBP2	MYCBP2	13q22	O75592	details
E3 ubiquitin-protein ligase MGRN1	MGRN1	16p13.3	O60291	details
E3 ubiquitin-protein ligase UBR2	UBR2	6p21.1	Q8IWV8	details
E3 ubiquitin-protein ligase UBR4	UBR4	1p36.13	Q5T4S7	details
E3 ubiquitin-protein ligase AMFR	AMFR	16q21	Q9UKV5	details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)	MYLIP		Q8WY64	details
HNP95	hNp95		Q96T88	details
Midline-1	MID1		O15344	details
CCR4-NOT transcription complex subunit 4	CNOT4	7q22-qter	O95628	details
E3 ubiquitin-protein ligase MARCH2	MARCH2	19p13.2	Q9P0N8	details
E3 ubiquitin-protein ligase UBR5	UBR5	8q22	O95071	details
E3 ubiquitin-protein ligase TRIM33	TRIM33	1p13.1	Q9UPN9	details
E3 ubiquitin-protein ligase MARCH5	MARCH5	10q23.32-q23.33	Q9NX47	details
E3 ubiquitin-protein ligase MARCH1	MARCH1	4q32.2	Q8TCQ1	details
E3 ubiquitin-protein ligase FANCL	FANCL	2p16.1	Q9NW38	details
E3 ubiquitin-protein ligase CHFR	CHFR	12q24.33	Q96EP1	details
E3 ubiquitin-protein ligase RAD18	RAD18	3p25-p24	Q9NS91	details
E3 ubiquitin-protein ligase MARCH4	MARCH4	2q35	Q9P2E8	details
E3 ubiquitin-protein ligase RNF5	RNF5	6p21.3	Q99942	details
Praja 1	PJA1		A2A322	details
RFWD2 protein	RFWD2	1q25.1-q25.2	Q05CT6	details
E3 ubiquitin-protein ligase SIAH1	SIAH1	16q12	Q8IUQ4	details
E3 ubiquitin-protein ligase SIAH2	SIAH2	3q25	O43255	details
E3 ubiquitin-protein ligase MARCH7	MARCH7	2q24.2	Q9H992	details
E3 ubiquitin-protein ligase RNF128	RNF128		Q8TEB7	details
E3 ubiquitin-protein ligase TRIM11	TRIM11	1q42.13	Q96F44	details
BRCA1 associated protein variant			Q59H81	details
E3 ubiquitin-protein ligase synoviolin	SYVN1	11q13	Q86TM6	details
E3 ubiquitin-protein ligase TRIM63	TRIM63	1p34-p33	Q969Q1	details
E3 ubiquitin-protein ligase LNX	LNX1	4q12	Q8TBB1	details
E3 ubiquitin-protein ligase ZNRF1	ZNRF1	16q23.1	Q8ND25	details
Tripartite motif-containing protein 5	TRIM5	11p15	Q9C035	details
E3 ubiquitin-protein ligase RNF8	RNF8	6p21.3	O76064	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details
E3 ubiquitin-protein ligase MARCH9	MARCH9	12q14.1	Q86YJ5	details
E3 ubiquitin-protein ligase DZIP3	DZIP3	3q13.13	Q86Y13	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
Protein farnesyltransferase subunit beta	FNTB	14q23.3	P49356	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
E3 ubiquitin-protein ligase MIB1	MIB1	18q11.2	Q86YT6	details
E3 ubiquitin-protein ligase RNF138	RNF138	18q12.1	Q8WVD3	details
E3 ubiquitin-protein ligase RING2	RNF2	1q25.3	Q99496	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
E3 ubiquitin-protein ligase RNF144B	RNF144B	6p22.3	Q7Z419	details
Decaprenyl-diphosphate synthase subunit 1	PDSS1	10p12.1	Q5T2R2	details
Poly(A) RNA polymerase GLD2	PAPD4	5q14.1	Q6PIY7	details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	HDDC3	15q26.1	Q8N4P3	details
tRNA dimethylallyltransferase, mitochondrial	TRIT1	1p34.2	Q9H3H1	details
PAP-associated domain-containing protein 5	PAPD5	16q12.1	Q8NDF8	details
DNA polymerase sigma	PAPD7	5p15	Q5XG87	details
Poly(A) polymerase beta	PAPOLB	7p22.1	Q9NRJ5	details
Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	14q11.2	Q92696	details
Geranylgeranyl transferase type-2 subunit beta	RABGGTB	1p31	P53611	details
HERV-K_5q33.3 provirus ancestral Pol protein			P10266	details
HERV-K_1q22 provirus ancestral Pol protein			P63135	details
HERV-K_11q22.1 provirus ancestral Pol protein			P63136	details
HERV-K_3q27.3 provirus ancestral Pol protein			Q9UQG0	details
HERV-K_7p22.1 provirus ancestral Pol protein	ERVK6		Q9BXR3	details
HERV-K_19q12 provirus ancestral Pol protein	ERVK6		Q9WJR5	details
HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein			P63128	details
HERV-K_19p13.11 provirus ancestral Pol protein			P63132	details
HERV-K_8p23.1 provirus ancestral Pol protein			P63133	details
HERV-K_1q23.3 provirus ancestral Pol protein			Q9QC07	details
DNA primase small subunit	PRIM1		P49642	details
DNA primase large subunit	PRIM2		P49643	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
tRNA-splicing ligase RtcB homolog	C22orf28	22q12	Q9Y3I0	details
Speckle targeted PIP5K1A-regulated poly(A) polymerase	TUT1	11q12.2	Q9H6E5	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details
Terminal uridylyltransferase 4	ZCCHC11	1p32.3	Q5TAX3	details
Terminal uridylyltransferase 7	ZCCHC6	9q21	Q5VYS8	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
Ubiquitin-conjugating enzyme E2 B	UBE2B	5q31.1	P63146	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Atrial natriuretic peptide receptor 2	NPR2	9p21-p12	P20594	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Retinal guanylyl cyclase 1	GUCY2D	17p13.1	Q02846	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Atrial natriuretic peptide receptor 1	NPR1	1q21-q22	P16066	details
Heat-stable enterotoxin receptor	GUCY2C	12p12	P25092	details
Retinal guanylyl cyclase 2	GUCY2F	Xq22	P51841	details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	FNTA	8p11	P49354	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Signal transduction protein CBL-C	CBLC	19q13.2	Q9ULV8	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
Ubiquitin-conjugating enzyme E2 D2	UBE2D2	5q31.2	P62837	details
Ubiquitin-conjugating enzyme E2 L3	UBE2L3	22q11.21	P68036	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase epsilon subunit 4	POLE4	2p12	Q9NR33	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA polymerase epsilon subunit 3	POLE3	9q33	Q9NRF9	details
DNA polymerase epsilon subunit 2	POLE2	14q21-q22	P56282	details
Poly(A) polymerase alpha	PAPOLA	14q32.31	P51003	details
mRNA-capping enzyme	RNGTT	6q16	O60942	details
Poly(A) polymerase gamma	PAPOLG	2p16.1	Q9BWT3	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
Myb-binding protein 1A	MYBBP1A	17p13.3	Q9BQG0	details
Poly(A) polymerase beta (Testis specific)	PAPOLB	7p22.1	A4D1Z6	details
DNA polymerase delta subunit 2	POLD2	7p13	P49005	details
Poly(A) RNA polymerase, mitochondrial	MTPAP	10p11.23	Q9NVV4	details
Poly(A) polymerase beta	PAPOLB	7p22.1	Q9NRJ5	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details
Terminal uridylyltransferase 4	ZCCHC11	1p32.3	Q5TAX3	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0155221

DrugBank ID

DB04160

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00019561

Chemspider ID

Not Available

KEGG Compound ID

C00013

BioCyc ID

PPI

BiGG ID

Not Available

Wikipedia Link

Pyrophosphate

METLIN ID

Not Available

PubChem Compound

1023

PDB ID

Not Available

ChEBI ID

29888

References

General References

Not Available

Only showing the first 10 proteins. There are 566 proteins in total.

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Enzymes

Enzyme Details

1. Acetyl-coenzyme A synthetase, cytoplasmic

General function:: Involved in acetate-CoA ligase activity
Specific function:: Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:: ACSS2
Uniprot ID:: Q9NR19
Molecular weight:: 78579.11

Enzyme Details

2. Acetyl-coenzyme A synthetase 2-like, mitochondrial

General function:: Involved in acetate-CoA ligase activity
Specific function:: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:: ACSS1
Uniprot ID:: Q9NUB1
Molecular weight:: 74625.88

Enzyme Details

3. Serum paraoxonase/lactonase 3

General function:: Involved in arylesterase activity
Specific function:: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:: PON3
Uniprot ID:: Q15166
Molecular weight:: 39607.185

Enzyme Details

4. Fucose-1-phosphate guanylyltransferase

General function:: Involved in fucose-1-phosphate guanylyltransferase acti
Specific function:: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
Gene Name:: FPGT
Uniprot ID:: O14772
Molecular weight:: 37630.405

Enzyme Details

5. Squalene synthase

General function:: Involved in transferase activity
Specific function:: Not Available
Gene Name:: FDFT1
Uniprot ID:: P37268
Molecular weight:: 48114.87

Enzyme Details

6. Phenylalanine--tRNA ligase alpha subunit

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: FARSA
Uniprot ID:: Q9Y285
Molecular weight:: 57563.225

Enzyme Details

7. Phenylalanine--tRNA ligase, mitochondrial

General function:: Involved in nucleotide binding
Specific function:: Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
Gene Name:: FARS2
Uniprot ID:: O95363
Molecular weight:: 52356.21

Enzyme Details

8. Alpha-aminoadipic semialdehyde dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:: ALDH7A1
Uniprot ID:: P49419
Molecular weight:: 58486.74

Enzyme Details

9. Amidophosphoribosyltransferase

General function:: Involved in amidophosphoribosyltransferase activity
Specific function:: Not Available
Gene Name:: PPAT
Uniprot ID:: Q06203
Molecular weight:: 57398.52

Enzyme Details

10. Nicotinamide mononucleotide adenylyltransferase 1

General function:: Involved in nucleotidyltransferase activity
Specific function:: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Gene Name:: NMNAT1
Uniprot ID:: Q9HAN9
Molecular weight:: 31932.22

Transporters

Enzyme Details

1. Very long-chain acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:: SLC27A2
Uniprot ID:: O14975
Molecular weight:: 64614.99

Enzyme Details

2. Bile acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:: SLC27A5
Uniprot ID:: Q9Y2P5
Molecular weight:: 75384.375

Enzyme Details

3. Acyl-CoA synthetase family member 4

General function:: Involved in acyl carrier activity
Specific function:: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:: AASDH
Uniprot ID:: Q4L235
Molecular weight:: 122596.1

Only showing the first 10 proteins. There are 566 proteins in total.

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Showing Compound Card for Pyrophosphate (CDB005103)

Structure for CDB005103 (Pyrophosphate)

Enzymes

Transporters