Record Information
Version1.0
Created at2020-04-17 19:09:37 UTC
Updated at2020-12-07 19:11:35 UTC
CannabisDB IDCDB005103
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NamePyrophosphate
DescriptionPyrophosphate, also known as diphosphorsaeure or H4P2O7, belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion. Pyrophosphate is a moderately acidic compound (based on its pKa). Pyrophosphate exists in all living species, ranging from bacteria to humans. In humans, pyrophosphate is involved in intracellular signalling through PGD2 receptor and prostaglandin D2. Pyrophosphate is a potentially toxic compound. An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid. Pyrophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
[(HO)2P(O)OP(O)(OH)2]ChEBI
Acide diphosphoriqueChEBI
DiphosphorsaeureChEBI
H4P2O7ChEBI
Pyrophosphoric acidChEBI
PyrophosphorsaeureChEBI
Diphosphoric acidKegg
PPiKegg
DiphosphateGenerator
PYROphosphATEChEBI
Na4p2O7MeSH, HMDB
PPi CPDMeSH, HMDB
Chemical FormulaH4O7P2
Average Molecular Weight177.98
Monoisotopic Molecular Weight177.9432
IUPAC Name(phosphonooxy)phosphonic acid
Traditional Namepyrophosphoric acid
CAS Registry Number33943-49-6
SMILES
OP(O)(=O)OP(O)(O)=O
InChI Identifier
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
InChI KeyXPPKVPWEQAFLFU-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal pyrophosphates
Direct ParentNon-metal pyrophosphates
Alternative Parents
Substituents
  • Non-metal pyrophosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Indirect biological role:

Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting Point61 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.4ChemAxon
pKa (Strongest Acidic)1.7ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area124.29 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity25.52 m³·mol⁻¹ChemAxon
Polarizability10.28 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSPyrophosphate, non-derivatized, GC-MS Spectrumsplash10-0002-0972000000-a80f120dd426991d6effSpectrum
GC-MSPyrophosphate, non-derivatized, GC-MS Spectrumsplash10-0udi-0741900000-9c5b3c334561dd282116Spectrum
GC-MSPyrophosphate, non-derivatized, GC-MS Spectrumsplash10-03di-0920000000-a5ad76aa129d898d71f8Spectrum
GC-MSPyrophosphate, non-derivatized, GC-MS Spectrumsplash10-03di-0910000000-531d3e19493dc29d6e5cSpectrum
GC-MSPyrophosphate, 4 TMS, GC-MS Spectrumsplash10-0udi-0320900000-0abbcb28a43d7e24fe81Spectrum
GC-MSPyrophosphate, non-derivatized, GC-MS Spectrumsplash10-0udi-0320900000-0abbcb28a43d7e24fe81Spectrum
Predicted GC-MSPyrophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0002-9200000000-47d5c2340766aaf36e95Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004j-5900000000-6633d5123eb37c266247Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0002-9000000000-1274b83242b279e9dac7Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-69bc4c795fec87fef4b8Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 1V, negativesplash10-0udi-0009000000-0d7e21d878a866bb58ceSpectrum
MS/MSLC-MS/MS Spectrum - QqQ 2V, negativesplash10-0a4i-0009000000-886725ef1e6e856bba4eSpectrum
MS/MSLC-MS/MS Spectrum - QqQ 3V, negativesplash10-0udi-0009000000-6ea52df356fc0219aae7Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 4V, negativesplash10-0udi-0009000000-bb05c17fd2d302e48d47Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 5V, negativesplash10-0udi-0109000000-884206603f4eb302c100Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 6V, negativesplash10-0udi-0109000000-f6479c3c70cf1da434a7Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 7V, negativesplash10-0udi-0219000000-8c9d253d3347c2b2a7b1Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 8V, negativesplash10-0ufr-0529000000-40db63b6f9bc6df64259Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 9V, negativesplash10-0a6r-0938000000-128abea42399dbbd6b73Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 10V, negativesplash10-004i-0923000000-bf96528807a30d13e941Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 11V, negativesplash10-004i-0922000000-7ba3aaba52e7bda31d59Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 12V, negativesplash10-004i-0911000000-729a221aabae27701a80Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 13V, negativesplash10-004i-0910000000-2fc64e199062885202b2Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 14V, negativesplash10-004i-0910000000-0d1641e2522b985110a8Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 15V, negativesplash10-004i-0910000000-fca1eea6589ac6828b32Spectrum
MS/MSLC-MS/MS Spectrum - QqQ 16V, negativesplash10-004i-0900000000-6fae5d4a6887e1ace201Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004j-4900000000-fab623ebd43ab1452b9fSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9400000000-b2565f0d436385569cffSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9300000000-ac978f84efc222da7b43Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-0900000000-21c64963e1ff18b360e1Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9700000000-54e41043f009fe6db86cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-2a5f69c16aa671275a62Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Acetyl-coenzyme A synthetase, cytoplasmicACSS220q11.22Q9NR19 details
Acetyl-coenzyme A synthetase 2-like, mitochondrialACSS120p11.23-p11.21Q9NUB1 details
Serum paraoxonase/lactonase 3PON37q21.3Q15166 details
Fucose-1-phosphate guanylyltransferaseFPGT1p31.1O14772 details
Squalene synthaseFDFT18p23.1-p22P37268 details
Phenylalanine--tRNA ligase alpha subunitFARSA19p13.2Q9Y285 details
Phenylalanine--tRNA ligase, mitochondrialFARS26p25.1O95363 details
Alpha-aminoadipic semialdehyde dehydrogenaseALDH7A15q31P49419 details
AmidophosphoribosyltransferasePPAT4q12Q06203 details
Nicotinamide mononucleotide adenylyltransferase 1NMNAT11p36.22Q9HAN9 details
Nicotinamide mononucleotide adenylyltransferase 3NMNAT33q23Q96T66 details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]QPRT16p11.2Q15274 details
Nicotinamide mononucleotide adenylyltransferase 2NMNAT21q25Q9BZQ4 details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1PAPSS14q24O43252 details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2PAPSS210q24O95340 details
N-acylneuraminate cytidylyltransferaseCMAS12p12.1Q8NFW8 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialDUT15q21.1P33316 details
Adenine phosphoribosyltransferaseAPRT16q24P07741 details
Hypoxanthine-guanine phosphoribosyltransferaseHPRT1Xq26.1P00492 details
Biotin--protein ligaseHLCS21q22.13P50747 details
Phenylalanine--tRNA ligase beta subunitFARSB2q36.1Q9NSD9 details
Ubiquitin-conjugating enzyme E2 AUBE2AXq24P49459 details
NEDD8-conjugating enzyme Ubc12UBE2M19q13.43P61081 details
Ubiquitin/ISG15-conjugating enzyme E2 L6UBE2L611q12O14933 details
Glycine--tRNA ligaseGARS7p15P41250 details
Bifunctional glutamate/proline--tRNA ligaseEPRS1q41P07814 details
Long-chain-fatty-acid--CoA ligase 4ACSL4Xq22.3-q23O60488 details
Tryptophan--tRNA ligase, cytoplasmicWARS14q32.31P23381 details
Long-chain-fatty-acid--CoA ligase 1ACSL14q35P33121 details
Ubiquitin-conjugating enzyme E2 G1UBE2G117p13.2P62253 details
Glutamine--tRNA ligaseQARS3p21.31P47897 details
Threonine--tRNA ligase, cytoplasmicTARS5p13.2P26639 details
Asparagine synthetase [glutamine-hydrolyzing]ASNS7q21.3P08243 details
Ubiquitin-conjugating enzyme E2 E2UBE2E23p24.2Q96LR5 details
Ubiquitin-conjugating enzyme E2 D2UBE2D25q31.2P62837 details
DNA ligase 4LIG413q33-q34P49917 details
Arginine--tRNA ligase, cytoplasmicRARS5q35.1P54136 details
GMP synthase [glutamine-hydrolyzing]GMPS3q24P49915 details
Ubiquitin-conjugating enzyme E2 BUBE2B5q31.1P63146 details
Probable leucine--tRNA ligase, mitochondrialLARS23p21.3Q15031 details
Ubiquitin-conjugating enzyme E2 J2UBE2J21p36.33Q8N2K1 details
Ubiquitin-conjugating enzyme E2 L3UBE2L322q11.21P68036 details
RNA 3'-terminal phosphate cyclaseRTCA1p21.2O00442 details
Tyrosine--tRNA ligase, cytoplasmicYARS1p35.1P54577 details
DNA ligase 3LIG317q11.2-q12P49916 details
Aspartate--tRNA ligase, cytoplasmicDARS2q21.3P14868 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
Asparagine--tRNA ligase, cytoplasmicNARS18q21.31O43776 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
Isoleucine--tRNA ligase, cytoplasmicIARS9q21P41252 details
Ubiquitin-like modifier-activating enzyme 1UBA1P22314 details
Tyrosine--tRNA ligase, mitochondrialYARS212p11.21Q9Y2Z4 details
Ubiquitin-conjugating enzyme E2 E1UBE2E13p24.2P51965 details
Long-chain-fatty-acid--CoA ligase 6ACSL65q31Q9UKU0 details
Methionine--tRNA ligase, cytoplasmicMARS12q13P56192 details
Alanine--tRNA ligase, cytoplasmicAARS16q22P49588 details
Tryptophan--tRNA ligase, mitochondrialWARS21p12Q9UGM6 details
Ribose-phosphate pyrophosphokinase 1PRPS1Xq21.32-q24P60891 details
Serine--tRNA ligase, mitochondrialSARS219q13.2Q9NP81 details
Ribose-phosphate pyrophosphokinase 2PRPS2Xp22.2P11908 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
Probable histidine--tRNA ligase, mitochondrialHARS25q31.3P49590 details
Ubiquitin-conjugating enzyme E2 J1UBE2J16q15Q9Y385 details
Long-chain-fatty-acid--CoA ligase 5ACSL510q25.1-q25.2Q9ULC5 details
Histidine--tRNA ligase, cytoplasmicHARS5q31.3P12081 details
Serine--tRNA ligase, cytoplasmicSARS1p13.3P49591 details
Long-chain-fatty-acid--CoA ligase 3ACSL32q34-q35O95573 details
Leucine--tRNA ligase, cytoplasmicLARS5q32Q9P2J5 details
Ubiquitin-conjugating enzyme E2 CUBE2C20q13.12O00762 details
Valine--tRNA ligaseVARS6p21.3P26640 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
Argininosuccinate synthaseASS19q34.1P00966 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Choline-phosphate cytidylyltransferase BPCYT1BXp22.11Q9Y5K3 details
DNA-directed RNA polymerase III subunit RPC4POLR3DP05423 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
Ethanolamine-phosphate cytidylyltransferasePCYT217q25.3Q99447 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase, mitochondrialPOLRMT19p13.3O00411 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC7POLR3GO15318 details
Phosphatidate cytidylyltransferase 2CDS220p13O95674 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
Choline-phosphate cytidylyltransferase APCYT1A3q29P49585 details
DNA-directed RNA polymerase I subunit RPA49POLR1E9p13.2Q9GZS1 details
DNA-directed RNA polymerase III subunit RPC8POLR3HQ9Y535 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
Phosphatidate cytidylyltransferase 1CDS14q21.23Q92903 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Geranylgeranyl pyrophosphate synthaseGGPS11q43O95749 details
Farnesyl pyrophosphate synthaseFDPS1q22P14324 details
DNA polymerase betaPOLB8p11.2P06746 details
DNA polymerase alpha catalytic subunitPOLA1Xp22.1-p21.3P09884 details
DNA polymerase lambdaPOLL10q23Q9UGP5 details
DNA polymerase epsilon subunit 4POLE42p12Q9NR33 details
DNA polymerase etaPOLH6p21.1Q9Y253 details
DNA polymerase delta catalytic subunitPOLD119q13.3P28340 details
DNA polymerase zeta catalytic subunitREV3L6q21O60673 details
DNA polymerase epsilon catalytic subunit APOLE12q24.3Q07864 details
DNA-directed DNA/RNA polymerase muPOLM7p13Q9NP87 details
DNA polymerase kappaPOLK5q13Q9UBT6 details
DNA polymerase epsilon subunit 3POLE39q33Q9NRF9 details
DNA polymerase subunit gamma-1POLG15q25P54098 details
DNA polymerase iotaPOLI18q21.1Q9UNA4 details
DNA polymerase epsilon subunit 2POLE214q21-q22P56282 details
Uridine 5'-monophosphate synthaseUMPS3q13P11172 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Retinal guanylyl cyclase 1GUCY2D17p13.1Q02846 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Inorganic pyrophosphatasePPA110q11.1-q24Q15181 details
Guanylate cyclase soluble subunit alpha-2GUCY1A211q21-q22P33402 details
UTP--glucose-1-phosphate uridylyltransferaseUGP22p14-p13Q16851 details
DNA nucleotidylexotransferaseDNTT10q23-q24P04053 details
Retinal guanylyl cyclase 2GUCY2FXq22P51841 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Poly(A) polymerase alphaPAPOLA14q32.31P51003 details
UDP-N-acetylhexosamine pyrophosphorylaseUAP11q23.3Q16222 details
Poly(A) polymerase gammaPAPOLG2p16.1Q9BWT3 details
Protoheme IX farnesyltransferase, mitochondrialCOX10Q12887 details
Geranylgeranyl transferase type-1 subunit betaPGGT1B5q22.3P53609 details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFNTA8p11P49354 details
Bifunctional coenzyme A synthaseCOASY17q12-q21Q13057 details
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Adenylyltransferase and sulfurtransferase MOCS3MOCS320q13.13O95396 details
E3 ubiquitin-protein ligase NEDD4-likeNEDD4L18q21Q96PU5 details
E3 ubiquitin-protein ligase Mdm2MDM212q14.3-q15Q00987 details
Telomerase reverse transcriptaseTERT5p15.33O14746 details
7,8-dihydro-8-oxoguanine triphosphataseNUDT17p22P36639 details
Phosphopantothenate--cysteine ligasePPCS1p34.2Q9HAB8 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Glutamine-dependent NAD(+) synthetaseNADSYN111q13.4Q6IA69 details
4-hydroxybenzoate polyprenyltransferase, mitochondrialCOQ24q21.23Q96H96 details
Mannose-1-phosphate guanyltransferase betaGMPPB3p21.31Q9Y5P6 details
Mannose-1-phosphate guanyltransferase alphaGMPPA2q35Q96IJ6 details
Methionine adenosyltransferase 2 subunit betaMAT2BQ9NZL9 details
Acetoacetyl-CoA synthetaseAACS12q24.31Q86V21 details
Adenylate cyclase type 10ADCY101q24Q96PN6 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
Inorganic pyrophosphatase 2, mitochondrialPPA24q25Q9H2U2 details
Probable arginine--tRNA ligase, mitochondrialRARS26q16.1Q5T160 details
Probable cysteine--tRNA ligase, mitochondrialCARS213q34Q9HA77 details
Probable glutamate--tRNA ligase, mitochondrialEARS216p12.2Q5JPH6 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
ACSS2 proteinACSS220q11.22Q96FY7 details
FAD synthaseFLAD11q21.3Q8NFF5 details
Valine--tRNA ligase, mitochondrialVARS26p21.33Q5ST30 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
Probable E3 ubiquitin-protein ligase HERC1HERC115q22Q15751 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Probable 8-oxo-dGTP diphosphatase NUDT15NUDT1513q14.2Q9NV35 details
CCA tRNA nucleotidyltransferase 1, mitochondrialTRNT13p25.1Q96Q11 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Nicotinamide phosphoribosyltransferaseNAMPT7q22.3P43490 details
Nicotinate phosphoribosyltransferaseNAPRT18q24.3Q6XQN6 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
Probable threonine--tRNA ligase 2, cytoplasmicTARSL215q26.3A2RTX5 details
Threonine--tRNA ligase, mitochondrialTARS21q21.3Q9BW92 details
Methionine--tRNA ligase, mitochondrialMARS22q33.1Q96GW9 details
Aspartate--tRNA ligase, mitochondrialDARS21q25.1Q6PI48 details
Cysteine--tRNA ligase, cytoplasmicCARS11p15.5P49589 details
FARSLA proteinFARSLAQ6IBR2 details
Probable asparagine--tRNA ligase, mitochondrialNARS211q14.1Q96I59 details
SUMO-activating enzyme subunit 2UBA219q12Q9UBT2 details
E3 ubiquitin-protein ligase HUWE1HUWE1Q7Z6Z7 details
E3 ubiquitin-protein ligase ToporsTOPORS9p21Q9NS56 details
STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)STUB116p13.3Q9UNE7 details
Ubiquitin conjugation factor E4 BUBE4B1p36.3O95155 details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)MARCH6O60337 details
TGIF-interacting ubiquitin ligase 1Q9H0M0 details
NEDD4-like E3 ubiquitin-protein ligase WWP2WWP216q22.1O00308 details
E3 ubiquitin-protein ligase MARCH3MARCH35q23.2Q86UD3 details
NEDD8-conjugating enzyme UBE2FUBE2F2q37.3Q969M7 details
Ubiquitin-conjugating enzyme E2 UUBE2U1p31.3Q5VVX9 details
Probable E3 ubiquitin-protein ligase MARCH10MARCH1017q23.2Q8NA82 details
E3 ubiquitin-protein ligase UBR1UBR115q13Q8IWV7 details
E3 ubiquitin-protein ligase MARCH8MARCH810q11.21Q5T0T0 details
E3 ubiquitin-protein ligase ZNRF2ZNRF27p14.3Q8NHG8 details
E3 ubiquitin-protein ligase TRIM32TRIM329q33.1Q13049 details
Probable E3 ubiquitin-protein ligase MYCBP2MYCBP213q22O75592 details
E3 ubiquitin-protein ligase MGRN1MGRN116p13.3O60291 details
E3 ubiquitin-protein ligase UBR2UBR26p21.1Q8IWV8 details
E3 ubiquitin-protein ligase UBR4UBR41p36.13Q5T4S7 details
E3 ubiquitin-protein ligase AMFRAMFR16q21Q9UKV5 details
Ubiquitin-conjugating enzyme E2 SUBE2S19q13.43Q16763 details
Pre-mRNA-processing factor 19PRPF1911q12.2Q9UMS4 details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)MYLIPQ8WY64 details
HNP95hNp95Q96T88 details
Putative ubiquitin-conjugating enzyme E2 N-likeUBE2NLQ5JXB2 details
Midline-1MID1O15344 details
E3 ubiquitin-protein ligase NEDD4NEDD415qP46934 details
CCR4-NOT transcription complex subunit 4CNOT47q22-qterO95628 details
E3 ubiquitin-protein ligase MARCH2MARCH219p13.2Q9P0N8 details
E3 ubiquitin-protein ligase UBR5UBR58q22O95071 details
E3 ubiquitin-protein ligase TRIM33TRIM331p13.1Q9UPN9 details
E3 ubiquitin-protein ligase MARCH5MARCH510q23.32-q23.33Q9NX47 details
Ubiquitin-conjugating enzyme E2 R2UBE2R29p13.3Q712K3 details
E3 ubiquitin-protein ligase MARCH1MARCH14q32.2Q8TCQ1 details
E3 ubiquitin-protein ligase FANCLFANCL2p16.1Q9NW38 details
Ubiquitin-like modifier-activating enzyme 6UBA64q13.2A0AVT1 details
Ubiquitin-conjugating enzyme E2 WUBE2W8q21.11Q96B02 details
Galactosyl transferase-associated proteinGTAPQ29SN7 details
E3 ubiquitin-protein ligase CHFRCHFR12q24.33Q96EP1 details
Ring finger protein 20RNF20Q5VTR2 details
E3 ubiquitin-protein ligase RAD18RAD183p25-p24Q9NS91 details
E3 ubiquitin ligase SMURF1SMURF17q22.1Q9HCE7 details
Baculoviral IAP repeat-containing protein 6BIRC62p22.3Q9NR09 details
E3 ubiquitin-protein ligase MARCH4MARCH42q35Q9P2E8 details
E3 ubiquitin-protein ligase CCNB1IP1CCNB1IP114q11.2Q9NPC3 details
E3 ubiquitin-protein ligase RNF5RNF56p21.3Q99942 details
Ubiquitin-conjugating enzyme E2 OUBE2O17q25.1Q9C0C9 details
Praja 1PJA1A2A322 details
RFWD2 proteinRFWD21q25.1-q25.2Q05CT6 details
E3 ubiquitin-protein ligase SMURF2SMURF217q22-q23Q9HAU4 details
E3 ubiquitin-protein ligase SIAH1SIAH116q12Q8IUQ4 details
E3 ubiquitin-protein ligase SIAH2SIAH23q25O43255 details
E3 ubiquitin-protein ligase MARCH7MARCH72q24.2Q9H992 details
Ubiquitin-conjugating enzyme E2 ZUBE2Z17q21.32Q9H832 details
Ubiquitin-like modifier-activating enzyme 7UBA73p21P41226 details
Ubiquitin carrier proteinUBE2H7q32A4D1L5 details
Ubiquitin-protein ligase E3AUBE3A15q11.2Q05086 details
E3 ubiquitin-protein ligase RNF128RNF128Q8TEB7 details
E3 ubiquitin-protein ligase TRIM11TRIM111q42.13Q96F44 details
BRCA1 associated protein variantQ59H81 details
E3 ubiquitin-protein ligase synoviolinSYVN111q13Q86TM6 details
E3 ubiquitin-protein ligase TRIM63TRIM631p34-p33Q969Q1 details
E3 ubiquitin-protein ligase LNXLNX14q12Q8TBB1 details
E3 ubiquitin-protein ligase ZNRF1ZNRF116q23.1Q8ND25 details
Tripartite motif-containing protein 5TRIM511p15Q9C035 details
Ubiquitin-protein ligase E3BUBE3B12q24.11Q7Z3V4 details
E3 ubiquitin-protein ligase RNF8RNF86p21.3O76064 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
Ubiquitin-conjugating enzyme E2 Q2UBE2Q215q24.2Q8WVN8 details
E3 ubiquitin-protein ligase MARCH9MARCH912q14.1Q86YJ5 details
Probable E3 ubiquitin-protein ligase TRIP12TRIP122q36.3Q14669 details
E3 ubiquitin-protein ligase DZIP3DZIP33q13.13Q86Y13 details
Ubiquitin-protein ligase E3CUBE3C7q36.3Q15386 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
DNA-directed RNA polymerases I and III subunit RPAC2POLR1D13q12.2Q9Y2S0 details
DNA-directed RNA polymeraseDKFZp686D10173Q7Z3R8 details
DNA-directed RNA polymerase III subunit RPC7-likePOLR3GLQ9BT43 details
POLR1C proteinPOLR1C6p21.1Q96HT3 details
tRNA isopentenyltransferase 1 variantTRIT11p34.2Q53F11 details
Myb-binding protein 1AMYBBP1A17p13.3Q9BQG0 details
DNA polymerase thetaPOLQ3q13.33O75417 details
Poly(A) polymerase beta (Testis specific)PAPOLB7p22.1A4D1Z6 details
Protein farnesyltransferase subunit betaFNTB14q23.3P49356 details
Alanine--tRNA ligase, mitochondrialAARS26p21.1Q5JTZ9 details
Isoleucine--tRNA ligase, mitochondrialIARS21q41Q9NSE4 details
Uracil phosphoribosyltransferase homologUPRTQ96BW1 details
Probable proline--tRNA ligase, mitochondrialPARS21p32.2Q7L3T8 details
Phospholysine phosphohistidine inorganic pyrophosphate phosphataseLHPP10q26.13Q9H008 details
Long-chain-fatty-acid--CoA ligase ACSBG2ACSBG219p13.3Q5FVE4 details
Long-chain-fatty-acid--CoA ligase ACSBG1ACSBG115q23-q24Q96GR2 details
E3 ubiquitin-protein ligase MIB1MIB118q11.2Q86YT6 details
E3 ubiquitin-protein ligase RNF138RNF13818q12.1Q8WVD3 details
E3 ubiquitin-protein ligase RING2RNF21q25.3Q99496 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
SUMO-activating enzyme subunit 1SAE119q13.32Q9UBE0 details
Ubiquitin-conjugating enzyme E2 D4UBE2D47p13Q9Y2X8 details
Ubiquitin conjugation factor E4 AUBE4A11q23.3Q14139 details
E3 ubiquitin-protein ligase RNF144BRNF144B6p22.3Q7Z419 details
Acyl-CoA synthetase short-chain family member 3, mitochondrialACSS312q21.31Q9H6R3 details
Cyclic GMP-AMP synthaseMB21D16q13Q8N884 details
dCTP pyrophosphatase 1DCTPP116p11.2Q9H773 details
Decaprenyl-diphosphate synthase subunit 2PDSS26q21Q86YH6 details
DNA polymerase delta subunit 2POLD27p13P49005 details
DNA polymerase subunit gamma-2, mitochondrialPOLG217qQ9UHN1 details
DNA polymerase nuPOLN4p16.3Q7Z5Q5 details
Decaprenyl-diphosphate synthase subunit 1PDSS110p12.1Q5T2R2 details
Adenosine monophosphate-protein transferase FICDFICD12q24.1Q9BVA6 details
Poly(A) RNA polymerase GLD2PAPD45q14.1Q6PIY7 details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1HDDC315q26.1Q8N4P3 details
tRNA dimethylallyltransferase, mitochondrialTRIT11p34.2Q9H3H1 details
Poly(A) RNA polymerase, mitochondrialMTPAP10p11.23Q9NVV4 details
DNA polymerase sigmaPAPD75p15Q5XG87 details
Poly(A) polymerase betaPAPOLB7p22.1Q9NRJ5 details
Geranylgeranyl transferase type-2 subunit alphaRABGGTA14q11.2Q92696 details
Geranylgeranyl transferase type-2 subunit betaRABGGTB1p31P53611 details
DNA primase small subunitPRIM1P49642 details
DNA primase large subunitPRIM2P49643 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerase I subunit RPA43TWISTNB7p21.1Q3B726 details
DNA-directed RNA polymerases I, II, and III subunit RPABC1POLR2E19p13.3P19388 details
DNA-directed RNA polymerases I, II, and III subunit RPABC2POLR2F22q13.1P61218 details
DNA-directed RNA polymerases I, II, and III subunit RPABC3POLR2H3q28P52434 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerases I and III subunit RPAC1POLR1C6p21.1O15160 details
DNA-directed RNA polymerase II subunit RPB11-aPOLR2J7q22.1P52435 details
DNA-directed RNA polymerase II subunit RPB11-b1POLR2J27q22.1Q9GZM3 details
DNA-directed RNA polymerase II subunit RPB3POLR2C16q13-q21P19387 details
DNA-directed RNA polymerase II subunit RPB4POLR2D2q21O15514 details
DNA-directed RNA polymerase II subunit RPB7POLR2G11q13.1P62487 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
DNA-directed RNA polymerase III subunit RPC3POLR3CQ9BUI4 details
DNA-directed RNA polymerase III subunit RPC5POLR3EQ9NVU0 details
DNA-directed RNA polymerase III subunit RPC6POLR3FQ9H1D9 details
tRNA-splicing ligase RtcB homologC22orf2822q12Q9Y3I0 details
Speckle targeted PIP5K1A-regulated poly(A) polymeraseTUT111q12.2Q9H6E5 details
Probable tRNA(His) guanylyltransferaseTHG1L5q33.3Q9NWX6 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Terminal uridylyltransferase 4ZCCHC111p32.3Q5TAX3 details
Terminal uridylyltransferase 7ZCCHC69q21Q5VYS8 details
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1UAP1L1Q3KQV9 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Serum paraoxonase/lactonase 3PON37q21.3Q15166 details
Phenylalanine--tRNA ligase, mitochondrialFARS26p25.1O95363 details
AmidophosphoribosyltransferasePPAT4q12Q06203 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
Phenylalanine--tRNA ligase beta subunitFARSB2q36.1Q9NSD9 details
DNA ligase 4LIG413q33-q34P49917 details
DNA ligase 3LIG317q11.2-q12P49916 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
Alanine--tRNA ligase, cytoplasmicAARS16q22P49588 details
Ribose-phosphate pyrophosphokinase 1PRPS1Xq21.32-q24P60891 details
Ribose-phosphate pyrophosphokinase 2PRPS2Xp22.2P11908 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Geranylgeranyl pyrophosphate synthaseGGPS11q43O95749 details
Farnesyl pyrophosphate synthaseFDPS1q22P14324 details
DNA polymerase betaPOLB8p11.2P06746 details
DNA polymerase alpha catalytic subunitPOLA1Xp22.1-p21.3P09884 details
DNA polymerase lambdaPOLL10q23Q9UGP5 details
DNA polymerase etaPOLH6p21.1Q9Y253 details
DNA polymerase delta catalytic subunitPOLD119q13.3P28340 details
DNA polymerase zeta catalytic subunitREV3L6q21O60673 details
DNA polymerase epsilon catalytic subunit APOLE12q24.3Q07864 details
DNA-directed DNA/RNA polymerase muPOLM7p13Q9NP87 details
DNA polymerase kappaPOLK5q13Q9UBT6 details
DNA polymerase iotaPOLI18q21.1Q9UNA4 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Inorganic pyrophosphatasePPA110q11.1-q24Q15181 details
Guanylate cyclase soluble subunit alpha-2GUCY1A211q21-q22P33402 details
UTP--glucose-1-phosphate uridylyltransferaseUGP22p14-p13Q16851 details
DNA nucleotidylexotransferaseDNTT10q23-q24P04053 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Poly(A) polymerase gammaPAPOLG2p16.1Q9BWT3 details
Geranylgeranyl transferase type-1 subunit betaPGGT1B5q22.3P53609 details
Adenylyltransferase and sulfurtransferase MOCS3MOCS320q13.13O95396 details
Molybdenum cofactor biosynthesis protein 1MOCS16p21.3Q9NZB8 details
E3 ubiquitin-protein ligase Mdm2MDM212q14.3-q15Q00987 details
Telomerase reverse transcriptaseTERT5p15.33O14746 details
GephyrinGPHN14q23.3Q9NQX3 details
7,8-dihydro-8-oxoguanine triphosphataseNUDT17p22P36639 details
Adenylate cyclase type 10ADCY101q24Q96PN6 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
Inorganic pyrophosphatase 2, mitochondrialPPA24q25Q9H2U2 details
Probable cysteine--tRNA ligase, mitochondrialCARS213q34Q9HA77 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Signal transduction protein CBL-CCBLC19q13.2Q9ULV8 details
Protein prune homologPRUNE1q21Q86TP1 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Probable 8-oxo-dGTP diphosphatase NUDT15NUDT1513q14.2Q9NV35 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
Cysteine--tRNA ligase, cytoplasmicCARS11p15.5P49589 details
E3 ubiquitin-protein ligase ToporsTOPORS9p21Q9NS56 details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)MARCH6O60337 details
E3 ubiquitin-protein ligase MARCH3MARCH35q23.2Q86UD3 details
Probable E3 ubiquitin-protein ligase MARCH10MARCH1017q23.2Q8NA82 details
E3 ubiquitin-protein ligase UBR1UBR115q13Q8IWV7 details
E3 ubiquitin-protein ligase MARCH8MARCH810q11.21Q5T0T0 details
E3 ubiquitin-protein ligase ZNRF2ZNRF27p14.3Q8NHG8 details
E3 ubiquitin-protein ligase TRIM32TRIM329q33.1Q13049 details
Probable E3 ubiquitin-protein ligase MYCBP2MYCBP213q22O75592 details
E3 ubiquitin-protein ligase MGRN1MGRN116p13.3O60291 details
E3 ubiquitin-protein ligase UBR2UBR26p21.1Q8IWV8 details
E3 ubiquitin-protein ligase UBR4UBR41p36.13Q5T4S7 details
E3 ubiquitin-protein ligase AMFRAMFR16q21Q9UKV5 details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)MYLIPQ8WY64 details
HNP95hNp95Q96T88 details
Midline-1MID1O15344 details
CCR4-NOT transcription complex subunit 4CNOT47q22-qterO95628 details
E3 ubiquitin-protein ligase MARCH2MARCH219p13.2Q9P0N8 details
E3 ubiquitin-protein ligase UBR5UBR58q22O95071 details
E3 ubiquitin-protein ligase TRIM33TRIM331p13.1Q9UPN9 details
E3 ubiquitin-protein ligase MARCH5MARCH510q23.32-q23.33Q9NX47 details
E3 ubiquitin-protein ligase MARCH1MARCH14q32.2Q8TCQ1 details
E3 ubiquitin-protein ligase FANCLFANCL2p16.1Q9NW38 details
E3 ubiquitin-protein ligase CHFRCHFR12q24.33Q96EP1 details
E3 ubiquitin-protein ligase RAD18RAD183p25-p24Q9NS91 details
E3 ubiquitin-protein ligase MARCH4MARCH42q35Q9P2E8 details
E3 ubiquitin-protein ligase RNF5RNF56p21.3Q99942 details
Praja 1PJA1A2A322 details
RFWD2 proteinRFWD21q25.1-q25.2Q05CT6 details
E3 ubiquitin-protein ligase SIAH1SIAH116q12Q8IUQ4 details
E3 ubiquitin-protein ligase SIAH2SIAH23q25O43255 details
E3 ubiquitin-protein ligase MARCH7MARCH72q24.2Q9H992 details
E3 ubiquitin-protein ligase RNF128RNF128Q8TEB7 details
E3 ubiquitin-protein ligase TRIM11TRIM111q42.13Q96F44 details
BRCA1 associated protein variantQ59H81 details
E3 ubiquitin-protein ligase synoviolinSYVN111q13Q86TM6 details
E3 ubiquitin-protein ligase TRIM63TRIM631p34-p33Q969Q1 details
E3 ubiquitin-protein ligase LNXLNX14q12Q8TBB1 details
E3 ubiquitin-protein ligase ZNRF1ZNRF116q23.1Q8ND25 details
Tripartite motif-containing protein 5TRIM511p15Q9C035 details
E3 ubiquitin-protein ligase RNF8RNF86p21.3O76064 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
E3 ubiquitin-protein ligase MARCH9MARCH912q14.1Q86YJ5 details
E3 ubiquitin-protein ligase DZIP3DZIP33q13.13Q86Y13 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
Protein farnesyltransferase subunit betaFNTB14q23.3P49356 details
Alanine--tRNA ligase, mitochondrialAARS26p21.1Q5JTZ9 details
E3 ubiquitin-protein ligase MIB1MIB118q11.2Q86YT6 details
E3 ubiquitin-protein ligase RNF138RNF13818q12.1Q8WVD3 details
E3 ubiquitin-protein ligase RING2RNF21q25.3Q99496 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
E3 ubiquitin-protein ligase RNF144BRNF144B6p22.3Q7Z419 details
Decaprenyl-diphosphate synthase subunit 1PDSS110p12.1Q5T2R2 details
Poly(A) RNA polymerase GLD2PAPD45q14.1Q6PIY7 details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1HDDC315q26.1Q8N4P3 details
tRNA dimethylallyltransferase, mitochondrialTRIT11p34.2Q9H3H1 details
PAP-associated domain-containing protein 5PAPD516q12.1Q8NDF8 details
DNA polymerase sigmaPAPD75p15Q5XG87 details
Poly(A) polymerase betaPAPOLB7p22.1Q9NRJ5 details
Geranylgeranyl transferase type-2 subunit alphaRABGGTA14q11.2Q92696 details
Geranylgeranyl transferase type-2 subunit betaRABGGTB1p31P53611 details
HERV-K_5q33.3 provirus ancestral Pol proteinP10266 details
HERV-K_1q22 provirus ancestral Pol proteinP63135 details
HERV-K_11q22.1 provirus ancestral Pol proteinP63136 details
HERV-K_3q27.3 provirus ancestral Pol proteinQ9UQG0 details
HERV-K_7p22.1 provirus ancestral Pol proteinERVK6Q9BXR3 details
HERV-K_19q12 provirus ancestral Pol proteinERVK6Q9WJR5 details
HERV-K_6q14.1 provirus ancestral Gag-Pol polyproteinP63128 details
HERV-K_19p13.11 provirus ancestral Pol proteinP63132 details
HERV-K_8p23.1 provirus ancestral Pol proteinP63133 details
HERV-K_1q23.3 provirus ancestral Pol proteinQ9QC07 details
DNA primase small subunitPRIM1P49642 details
DNA primase large subunitPRIM2P49643 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
tRNA-splicing ligase RtcB homologC22orf2822q12Q9Y3I0 details
Speckle targeted PIP5K1A-regulated poly(A) polymeraseTUT111q12.2Q9H6E5 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Terminal uridylyltransferase 4ZCCHC111p32.3Q5TAX3 details
Terminal uridylyltransferase 7ZCCHC69q21Q5VYS8 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Ubiquitin-conjugating enzyme E2 D1UBE2D110q21.1P51668 details
DNA ligase 4LIG413q33-q34P49917 details
Ubiquitin-conjugating enzyme E2 BUBE2B5q31.1P63146 details
Tyrosine--tRNA ligase, cytoplasmicYARS1p35.1P54577 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Atrial natriuretic peptide receptor 2NPR29p21-p12P20594 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Retinal guanylyl cyclase 1GUCY2D17p13.1Q02846 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Atrial natriuretic peptide receptor 1NPR11q21-q22P16066 details
Heat-stable enterotoxin receptorGUCY2C12p12P25092 details
Retinal guanylyl cyclase 2GUCY2FXq22P51841 details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFNTA8p11P49354 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Signal transduction protein CBL-CCBLC19q13.2Q9ULV8 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Ubiquitin-conjugating enzyme E2 D1UBE2D110q21.1P51668 details
Ubiquitin-conjugating enzyme E2 D2UBE2D25q31.2P62837 details
Ubiquitin-conjugating enzyme E2 L3UBE2L322q11.21P68036 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
DNA-directed RNA polymerase III subunit RPC4POLR3DP05423 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase, mitochondrialPOLRMT19p13.3O00411 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC7POLR3GO15318 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
DNA-directed RNA polymerase I subunit RPA49POLR1E9p13.2Q9GZS1 details
DNA-directed RNA polymerase III subunit RPC8POLR3HQ9Y535 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
DNA polymerase alpha catalytic subunitPOLA1Xp22.1-p21.3P09884 details
DNA polymerase epsilon subunit 4POLE42p12Q9NR33 details
DNA polymerase delta catalytic subunitPOLD119q13.3P28340 details
DNA polymerase epsilon catalytic subunit APOLE12q24.3Q07864 details
DNA polymerase epsilon subunit 3POLE39q33Q9NRF9 details
DNA polymerase epsilon subunit 2POLE214q21-q22P56282 details
Poly(A) polymerase alphaPAPOLA14q32.31P51003 details
mRNA-capping enzymeRNGTT6q16O60942 details
Poly(A) polymerase gammaPAPOLG2p16.1Q9BWT3 details
Nicotinamide phosphoribosyltransferaseNAMPT7q22.3P43490 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
DNA-directed RNA polymerases I and III subunit RPAC2POLR1D13q12.2Q9Y2S0 details
DNA-directed RNA polymeraseDKFZp686D10173Q7Z3R8 details
DNA-directed RNA polymerase III subunit RPC7-likePOLR3GLQ9BT43 details
POLR1C proteinPOLR1C6p21.1Q96HT3 details
Myb-binding protein 1AMYBBP1A17p13.3Q9BQG0 details
Poly(A) polymerase beta (Testis specific)PAPOLB7p22.1A4D1Z6 details
DNA polymerase delta subunit 2POLD27p13P49005 details
Poly(A) RNA polymerase, mitochondrialMTPAP10p11.23Q9NVV4 details
Poly(A) polymerase betaPAPOLB7p22.1Q9NRJ5 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerase I subunit RPA43TWISTNB7p21.1Q3B726 details
DNA-directed RNA polymerases I, II, and III subunit RPABC1POLR2E19p13.3P19388 details
DNA-directed RNA polymerases I, II, and III subunit RPABC2POLR2F22q13.1P61218 details
DNA-directed RNA polymerases I, II, and III subunit RPABC3POLR2H3q28P52434 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerases I and III subunit RPAC1POLR1C6p21.1O15160 details
DNA-directed RNA polymerase II subunit RPB11-aPOLR2J7q22.1P52435 details
DNA-directed RNA polymerase II subunit RPB11-b1POLR2J27q22.1Q9GZM3 details
DNA-directed RNA polymerase II subunit RPB3POLR2C16q13-q21P19387 details
DNA-directed RNA polymerase II subunit RPB4POLR2D2q21O15514 details
DNA-directed RNA polymerase II subunit RPB7POLR2G11q13.1P62487 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
DNA-directed RNA polymerase III subunit RPC3POLR3CQ9BUI4 details
DNA-directed RNA polymerase III subunit RPC5POLR3EQ9NVU0 details
DNA-directed RNA polymerase III subunit RPC6POLR3FQ9H1D9 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Terminal uridylyltransferase 4ZCCHC111p32.3Q5TAX3 details
Concentrations Data
Not Available
HMDB IDHMDB0155221
DrugBank IDDB04160
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDC00019561
Chemspider IDNot Available
KEGG Compound IDC00013
BioCyc IDPPI
BiGG IDNot Available
Wikipedia LinkPyrophosphate
METLIN IDNot Available
PubChem Compound1023
PDB IDNot Available
ChEBI ID29888
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 566 proteins in total.

Enzymes

General function:
Involved in acetate-CoA ligase activity
Specific function:
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:
ACSS2
Uniprot ID:
Q9NR19
Molecular weight:
78579.11
General function:
Involved in acetate-CoA ligase activity
Specific function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Molecular weight:
74625.88
General function:
Involved in arylesterase activity
Specific function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular weight:
39607.185
General function:
Involved in fucose-1-phosphate guanylyltransferase acti
Specific function:
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
Gene Name:
FPGT
Uniprot ID:
O14772
Molecular weight:
37630.405
General function:
Involved in transferase activity
Specific function:
Not Available
Gene Name:
FDFT1
Uniprot ID:
P37268
Molecular weight:
48114.87
General function:
Involved in nucleotide binding
Specific function:
Not Available
Gene Name:
FARSA
Uniprot ID:
Q9Y285
Molecular weight:
57563.225
General function:
Involved in nucleotide binding
Specific function:
Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
Gene Name:
FARS2
Uniprot ID:
O95363
Molecular weight:
52356.21
General function:
Involved in oxidoreductase activity
Specific function:
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:
ALDH7A1
Uniprot ID:
P49419
Molecular weight:
58486.74
General function:
Involved in amidophosphoribosyltransferase activity
Specific function:
Not Available
Gene Name:
PPAT
Uniprot ID:
Q06203
Molecular weight:
57398.52
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Gene Name:
NMNAT1
Uniprot ID:
Q9HAN9
Molecular weight:
31932.22

Transporters

General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:
SLC27A2
Uniprot ID:
O14975
Molecular weight:
64614.99
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:
SLC27A5
Uniprot ID:
Q9Y2P5
Molecular weight:
75384.375
General function:
Involved in acyl carrier activity
Specific function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:
AASDH
Uniprot ID:
Q4L235
Molecular weight:
122596.1

Only showing the first 10 proteins. There are 566 proteins in total.