| Identification |
|---|
| HMDB Protein ID
| CDBP04409 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase UBR4 |
| Description
| Not Available |
| Synonyms
|
- 600 kDa retinoblastoma protein-associated factor
- N-recognin-4
- RBAF600
- Retinoblastoma-associated factor of 600 kDa
- Zinc finger UBR1-type protein 1
- p600
|
| Gene Name
| UBR4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ubiquitin-protein ligase activity |
| Specific Function
| E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions |
| GO Classification
|
| Function |
| small conjugating protein ligase activity |
| transition metal ion binding |
| zinc ion binding |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| ubiquitin-protein ligase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- Membrane
- Multi-pass membrane protein (Potential)
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.13 |
| SNPs
| UBR4 |
| Gene Sequence
|
>15552 bp
ATGGCGACGAGCGGCGGCGAAGAGGCGGCGGCAGCGGCTCCGGCGCCGGGGACCCCGGCA
ACGGGGGCGGACACGACCCCGGGCTGGGAGGTGGCTGTGCGGCCCCTGCTGTCCGCGTCC
TACTCCGCCTTCGAGATGAAGGAGTTGCCGCAGCTGGTGGCCTCAGTCATCGAGAGTGAA
TCAGAAATCCTGCACCATGAGAAGCAGTACGAGCCATTCTACTCATCTTTTGTTGCACTT
TCCACACACTATATTACAACAGTTTGCAGTCTCATTCCCCGGAACCAACTTCAGTCAGTG
GCAGCAGCCTGTAAAGTTCTAATTGAGTTTTCTCTCCTGCGTCTGGAGAATCCAGATGAG
GCTTGTGCTGTGTCCCAGAAACACTTGATTCTCCTAATCAAGGGCCTGTGCACTGGCTGT
AGCCGACTAGATAGAACTGAAATTATCACATTTACAGCAATGATGAAATCCGCCAAGCTG
CCCCAAACAGTGAAGACACTTTCAGACGTGGAAGATCAGAAAGAGCTGGCCTCACCAGTA
AGCCCTGAGTTGAGGCAAAAGGAGGTACAGATGAATTTTTTGAACCAGCTGACCTCAGTT
TTTAACCCTAGAACTGTAGCATCACAACCTATCAGTACACAGACTCTGGTGGAAGGAGAA
AATGATGAGCAGTCATCTACAGATCAAGCCTCAGCTATCAAAACCAAGAATGTGTTCATA
GCTCAGAACGTGGCTAGTCTTCAAGAGCTTGGTGGCTCGGAGAAGCTACTGCGTGTATGT
TTGAACCTGCCATATTTCCTACGCTATATCAATCGGTTCCAAGATGCAGTTTTAGCTAAT
TCCTTCTTCATAATGCCTGCAACAGTAGCAGATGCCACTGCTGTTCGTAATGGCTTTCAT
TCATTGGTGATTGATGTAACTATGGCATTGGATACCCTTTCTCTACCTGTGTTGGAACCT
CTCAATCCTTCTCGTCTACAAGATGTGACAGTCCTCAGCCTAAGTTGTCTGTATGCAGGT
GTGAGTGTGGCAACGTGCATGGCCATCCTCCATGTGGGTAGTGCCCAGCAAGTGCGGACA
GGGTCCACGAGCTCCAAAGAAGATGACTATGAAAGTGACGCAGCTACAATTGTCCAGAAA
TGTCTCGAAATCTATGACATGATTGGACAAGCAATCAGCAGTTCTCGCCGGGCTGGTGGT
GAGCACTATCAGAATTTCCAATTGCTGGGTGCTTGGTGCTTGTTAAACAGCCTTTTCCTC
ATACTGAACCTCAGTCCTACTGCGTTGGCTGATAAGGGGAAAGAGAAGGACCCACTGGCT
GCCCTCCGAGTCAGAGACATCCTTTCTCGTACTAAAGAGGGAGTGGGCTCCCCTAAACTG
GGGCCTGGAAAAGGGCATCAGGGATTTGGGGTACTCTCAGTAATATTGGCAAACCATGCC
ATCAAACTGCTAACGTCTCTCTTTCAAGACCTACAAGTGGAGGCCCTTCACAAGGGTTGG
GAGACAGATGGCCCCCCTGCAGCCTTGAGCATTATGGCCCAGAGCACCTCCATACAGAGG
ATTCAACGGCTGATTGACTCTGTCCCACTGATGAACCTGCTCTTGACGTTACTTTCAACT
TCCTACAGAAAGGCATGTGTCCTGCAGCGGCAGAGGAAGGGCTCCATGAGCAGCGATGCC
AGCGCCTCCACCGACTCCAATACTTACTATGAGGACGATTTCAGTAGCACGGAGGAGGAC
AGCAGCCAAGACGATGACAGTGAGCCTATTTTGGGGCAATGGTTTGAGGAGACTATTTCT
CCCAGTAAAGAGAAAGCAGCACCTCCGCCTCCTCCCCCACCTCCTCCACTGGAAAGCTCT
CCTCGGGTTAAAAGCCCCAGTAAGCAGGCCCCTGGTGAGAAGGGCAACATTCTGGCGAGT
CGCAAAGATCCTGAGTTGTTCTTAGGTCTGGCTTCCAACATTTTGAACTTCATCACCTCT
TCCATGCTGAACTCTCGGAACAATTTTATCCGAAACTATCTGAGTGTATCTCTTTCAGAA
CACCATATGGCCACCCTAGCCAGTATCATCAAGGAGGTGGACAAAGATGGACTCAAGGGT
TCATCAGATGAAGAGTTTGCTGCAGCTCTCTATCACTTCAACCACTCACTGGTAACCTCT
GACCTTCAGTCACCTAACCTGCAGAACACACTGTTGCAGCAGCTAGGAGTGGCTCCTTTT
TCTGAGGGCCCTTGGCCCTTGTACATTCACCCTCAAAGCCTCTCTGTGCTTTCACGCCTC
CTGCTCATCTGGCAACATAAAGCCAGTGCTCAAGGTGACCCTGACGTCCCAGAATGCCTT
AAAGTTTGGGACAGGTTTTTGTCTACAATGAAGCAGAATGCCCTGCAAGGTGTGGTGCCC
AGTGAGACAGAGGATCTGAATGTAGAACACCTGCAGATGCTCCTCCTCATTTTCCACAAT
TTCACCGAGACAGGCCGGCGGGCCATATTGTCGCTTTTTGTCCAGATCATCCAGGAGTTG
AGCGTCAACATGGATGCTCAGATGCGCTTCGTGCCGCTTATCTTGGCTCGCCTCCTTCTC
ATCTTTGATTATCTGCTTCATCAGTACTCCAAAGCCCCTGTGTATCTATTTGAGCAGGTA
CAGCATAACCTGCTAAGTCCTCCCTTTGGGTGGGCAAGTGGATCCCAGGACAGCAACAGC
CGCCGGGCAACCACTCCTCTCTATCATGGATTCAAAGAAGTAGAAGAAAACTGGTCTAAG
CATTTCTCATCAGATGCTGTCCCACACCCCAGATTCTACTGTGTCCTGTCCCCAGAAGCC
TCAGAGGATGATTTGAACCGACTTGATTCTGTGGCATGTGACGTCCTTTTCTCCAAGCTT
GTCAAGTATGATGAGCTTTATGCTGCACTGACAGCCCTGCTTGCAGCTGGGTCCCAGCTT
GATACAGTTAGGAGAAAGGAAAACAAGAATGTAACAGCCTTGGAGGCCTGTGCCCTTCAA
TATTACTTCTTGATACTGTGGAGGATCCTAGGAATTTTACCACCATCAAAGACTTACATT
AACCAGCTATCCATGAACTCACCTGAGATGAGCGAATGTGACATCTTGCACACTCTGCGA
TGGTCTTCTCGGCTCCGGATCAGCTCCTATGTCAACTGGATAAAGGATCACCTTATCAAA
CAGGGAATGAAGGCTGAGCATGCTAGCTCGCTTCTAGAACTGGCATCCACCACTAAGTGT
AGCTCAGTGAAATATGATGTTGAAATAGTAGAGGAATACTTCGCTCGACAGATCTCATCC
TTCTGTAGTATCGACTGTACCACCATCTTGCAGCTGCATGAAATTCCCAGTCTGCAGTCC
ATCTACACCCTTGATGCCGCGATCTCAAAGGTCCAGGTCTCTTTGGATGAGCATTTTTCT
AAGATGGCTGCTGAGACTGATCCTCATAAGTCGTCTGAGATTACCAAGAACCTACTTCCA
GCCACGCTGCAACTCATTGACACCTATGCATCGTTCACCAGAGCCTATTTGCTGCAAAAC
TTTAATGAAGAGGGAACAACTGAGAAACCTTCCAAGGAGAAACTGCAAGGCTTTGCTGCT
GTTTTGGCTATTGGCTCTAGCAGGTGCAAGGCAAATACTCTGGGTCCGACACTGGTTCAG
AATTTGCCATCGTCAGTGCAGACTGTGTGTGAGTCCTGGAACAACATCAATACCAATGAA
TTTCCCAATATTGGATCCTGGCGCAATGCCTTTGCCAATGACACCATCCCTTCAGAGAGT
TATATTAGTGCAGTGCAGGCTGCACACCTGGGGACTCTCTGTAGCCAAAGTCTGCCCCTG
GCTGCTTCCCTGAAGCATACCCTCCTCTCACTGGTCAGGTTGACTGGAGATCTTATTGTT
TGGTCAGATGAGATGAACCCACCACAGGTAATTCGGACACTGCTACCTCTTCTTTTGGAA
TCAAGCACTGAGAGTGTTGCCGAGATCAGTAGCAACTCCCTGGAACGCATCTTGGGCCCT
GCTGAGTCTGATGAGTTCTTGGCTCGTGTTTATGAGAAGCTGATCACTGGTTGTTACAAC
ATTCTGGCCAATCATGCAGATCCTAACAGTGGACTGGATGAATCCATCCTGGAGGAATGT
CTCCAGTACTTGGAAAAGCAGCTGGAAAGTAGCCAGGCTCGTAAAGCTATGGAGGAGTTT
TTCTCTGACAGTGGAGAACTTGTACAGATCATGATGGCAACAGCCAATGAGAACCTCTCT
GCTAAATTCTGTAACCGAGTTTTGAAATTCTTCACCAAACTCTTCCAGCTGACTGAGAAG
AGCCCTAACCCGAGCCTGTTGCATCTCTGTGGCTCCCTGGCACAACTGGCCTGTGTGGAA
CCTGTGCGCCTGCAGGCCTGGCTCACCCGCATGACTACATCGCCCCCAAAAGATTCTGAT
CAGCTGGATGTAATTCAGGAGAACCGGCAGCTGCTGCAGTTACTGACCACATACATTGTT
CGGGAAAACAGCCAAGTTGGGGAAGGTGTGTGTGCTGTTCTTCTGGGCACCCTGACTCCC
ATGGCAACAGAGATGCTGGCCAACGGTGATGGGACTGGCTTCCCTGAACTTATGGTTGTG
ATGGCCACTCTGGCCAGTGCAGGTCAAGGTGCTGGTCACCTTCAGCTTCATAATGCTGCT
GTGGATTGGCTGAGCAGATGCAAGAAATACCTGTCACAGAAGAATGTAGTTGAAAAACTG
AATGCCAATGTAATGCATGGAAAGCATGTGATGATCTTGGAGTGCACATGCCATATCATG
TCTTACTTGGCTGATGTCACGAATGCCCTGAGCCAGAGTAATGGTCAAGGCCCAAGTCAT
CTCTCAGTGGATGGGGAAGAGCGGGCCATTGAAGTAGACTCAGACTGGGTGGAGGAGTTG
GCGGTGGAAGAGGAAGATTCCCAGGCTGAGGATTCAGATGAAGATTCTCTTTGCAATAAA
CTCTGCACTTTTACGATCACACAGAAAGAATTCATGAACCAGCATTGGTACCACTGTCAC
ACCTGTAAAATGGTGGATGGCGTGGGTGTCTGCACAGTGTGTGCTAAGGTGTGCCACAAG
GATCATGAGATTTCCTATGCCAAGTATGGATCCTTCTTCTGTGACTGTGGAGCCAAGGAA
GATGGCAGCTGTTTGGCTCTGGTGAAGAGAACTCCTAGCAGTGGCATGAGCTCTACCATG
AAGGAGTCGGCATTTCAGAGTGAACCCAGGATTTCAGAGAGTCTAGTGCGTCATGCCAGC
ACCTCCTCGCCAGCTGACAAAGCCAAGGTTACCATCAGTGATGGAAAGGTTGCTGACGAA
GAGAAGCCCAAGAAGAGCAGCCTCTGCCGCACAGTAGAGGGCTGCCGGGAGGAATTACAG
AACCAGGCCAATTTCTCCTTCGCTCCTCTCGTGTTAGACATGCTTAATTTCCTTATGGAT
GCCATTCAGACCAACTTCCAGCAAGCTTCAGCCGTCGGGAGCAGCAGCCGTGCTCAGCAA
GCCCTCAGTGAGCTACACACTGTGGAGAAGGCAGTGGAGATGACAGACCAGCTGATGGTT
CCCACCTTAGGGTCCCAGGAAGGTGCCTTTGAGAATGTGCGGATGAATTACAGTGGAGAC
CAGGGCCAGACCATCCGGCAGCTGATCAGTGCTCATGTGCTCAGGCGGGTGGCTATGTGT
GTGCTCTCCTCTCCCCATGGGCGCCGCCAACATTTGGCTGTCAGCCATGAGAAGGGCAAG
ATCACCGTTCTGCAGCTCTCTGCACTCCTGAAGCAAGCAGATTCCAGCAAAAGGAAGTTA
ACTCTGACCCGCTTGGCTTCTGCCCCAGTTCCTTTTACTGTGTTGAGCCTCACAGGAAAT
CCCTGCAAGGAAGACTACTTGGCGGTTTGTGGGCTAAAGGACTGTCATGTGCTCACCTTT
AGTAGCTCAGGCTCTGTTTCGGATCACTTGGTTTTGCACCCTCAGTTGGCAACGGGGAAC
TTCATCATCAAAGCCGTGTGGTTACCTGGTTCACAGACCGAGTTAGCAATTGTCACCGCA
GACTTTGTTAAGATTTATGACCTGTGTGTTGATGCCTTGAGTCCAACCTTCTATTTTCTC
CTGCCAAGCTCAAAGATAAGAGATGTTACCTTCCTTTTCAATGAGGAGGGAAAGAACATC
ATTGTTATAATGTCTTCGGCTGGGTACATCTATACTCAGCTTATGGAAGAGGCCAGCAGT
GCCCAGCAGGGACCCTTCTATGTCACTAATGTGTTGGAAATCAATCATGAGGACCTGAAG
GACAGTAACAGCCAGGTGGCGGGCGGTGGTGTGTCCGTGTACTACTCCCACGTGTTGCAG
ATGTTGTTCTTCAGCTATTGTCAAGGCAAATCATTCGCAGCCACCATCAGCAGGACAACC
CTGGAGGTGTTGCAACTCTTCCCCATCAACATCAAAAGTTCCAATGGTGGCAGTAAGACT
TCTCCTGCTCTTTGCCAGTGGTCTGAGGTGATGAACCACCCTGGCTTGGTGTGCTGTGTC
CAGCAAACTACAGGGGTGCCGCTGGTAGTTATGGTGAAACCAGACACTTTTCTTATCCAG
GAGATTAAGACTCTTCCTGCTAAAGCGAAGATCCAAGACATGGTTGCTATTAGGCACACG
GCCTGCAATGAGCAGCAGCGGACAACAATGATTCTGCTGTGTGAGGATGGCAGCCTGCGC
ATTTACATGGCCAACGTGGAGAACACCTCCTACTGGCTGCAGCCATCCCTGCAGCCCAGC
AGTGTCATCAGCATCATGAAGCCTGTTCGAAAGCGCAAAACAGCTACAATCACAACCCGC
ACGTCTAGCCAGGTGACTTTCCCCATTGACTTTTTTGAACACAACCAGCAGCTGACAGAT
GTGGAGTTTGGTGGTAACGACCTCCTACAGGTCTATAATGCACAACAGATAAAACACCGG
CTGAATTCCACTGGCATGTATGTGGCCAACACCAAGCCCGGAGGCTTCACCATTGAGATT
AGTAACAACAATAGCACTATGGTGATGACAGGCATGCGGATCCAGATTGGGACTCAAGCA
ATAGAACGGGCCCCGTCATATATCGAGATCTTCGGCAGAACTATGCAGCTCAACCTGAGT
CGCTCACGCTGGTTTGACTTCCCCTTCACCAGAGAAGAAGCCCTGCAGGCTGATAAGAAG
CTGAACCTCTTCATTGGGGCCTCGGTGGATCCAGCAGGTGTCACCATGATAGATGCTGTA
AAAATTTATGGCAAGACTAAGGAGCAGTTTGGCTGGCCTGATGAGCCCCCAGAAGAATTC
CCTTCTGCCTCTGTCAGCAACATCTGCCCTTCAAATCTGAACCAGAGCAACGGCACTGGA
GATAGCGACTCAGCTGCCCCCACTACGACCAGTGGAACTGTCCTGGAGAGGCTGGTTGTG
AGTTCTTTAGAAGCCCTGGAAAGCTGCTTTGCCGTTGGCCCAATCATCGAGAAGGAGAGA
AACAAGAATGCTGCTCAGGAGCTGGCCACTTTGCTGTTGTCCCTGCCAGCACCTGCCAGT
GTCCAGCAGCAGTCCAAGAGCCTTCTGGCCAGCCTGCACACCAGCCGCTCGGCCTACCAC
AGCCACAAGGATCAGGCCTTGCTGAGCAAAGCTGTGCAGTGTCTCAACACATCTAGCAAA
GAGGGCAAGGATTTGGACCCTGAGGTGTTCCAGAGGCTAGTGATCACAGCTCGCTCCATT
GCCATCATGCGCCCCAACAACCTTGTCCACTTTACGGAGTCAAAGCTGCCCCAGATGGAA
ACAGAAGGAATGGATGAAGGGAAGGAACCGCAGAAGCAGTTGGAAGGAGATTGCTGTAGT
TTCATCACCCAGCTTGTGAACCACTTCTGGAAACTCCATGCATCCAAACCCAAGAATGCC
TTCTTGGCACCTGCCTGCCTTCCAGGACTAACTCATATTGAAGCTACTGTCAATGCTCTG
GTGGACATCATCCATGGCTACTGTACCTGTGAGCTGGATTGTATTAACACAGCATCCAAG
ATCTACATGCAGATGCTCTTGTGTCCTGATCCTGCTGTGAGCTTCTCTTGTAAACAAGCT
CTAATTCGAGTCCTAAGGCCCAGGAACAAACGGAGACATGTGACTTTACCCTCTTCCCCT
CGAAGCAACACTCCAATGGGAGACAAGGATGATGATGACGATGATGATGCAGATGAGAAA
ATGCAGTCATCAGGGATCCCGAATGGTGGTCACATCCGTCAGGAAAGCCAGGAACAGAGT
GAGGTGGACCATGGAGATTTTGAGATGGTGTCTGAGTCGATGGTCCTGGAGACAGCTGAA
AATGTCAACAATGGCAACCCCTCTCCCCTGGAGGCCCTGCTGGCAGGCGCAGAGGGCTTC
CCCCCCATGCTGGACATCCCACCTGATGCAGATGACGAGACCATGGTTGAACTAGCCATT
GCCCTGAGCCTGCAGCAGGACCAACAAGGCAGCAGCAGCAGTGCCCTGGGCCTGCAGAGC
CTGGGACTGTCCGGCCAGGCACCCAGCTCTTCCTCTCTGGACGCAGGAACCCTCTCTGAC
ACCACAGCATCAGCTCCAGCCTCAGACGACGAGGGCAGTACAGCAGCGACAGATGGTTCT
ACCCTTCGGACCTCTCCTGCTGACCACGGTGGTAGTGTGGGCTCGGAGAGCGGGGGCAGT
GCAGTGGACTCAGTGGCTGGCGAGCACAGTGTATCTGGCCGGAGCAGTGCTTATGGCGAT
GCTACAGCTGAGGGGCATCCGGCTGGACCAGGAAGTGTCAGCTCAAGCACTGGAGCCATC
AGCACCACCACTGGGCACCAGGAGGGAGATGGCTCCGAGGGAGAAGGAGAAGGAGAAACT
GAAGGAGATGTCCACACTAGCAACAGGCTGCACATGGTCCGTCTAATGCTGTTGGAGAGA
TTACTGCAGACCCTGCCTCAATTACGAAACGTTGGCGGTGTCCGGGCCATCCCATACATG
CAGGTCATTCTAATGCTCACTACAGATCTGGATGGAGAAGATGAGAAAGACAAGGGGGCC
CTAGACAACCTGCTCTCCCAGCTTATTGCTGAGTTGGGTATGGATAAAAAGGATGTCTCC
AAGAAGAATGAGCGCAGCGCCCTGAATGAAGTCCATCTGGTAGTAATGAGACTCCTGAGT
GTCTTCATGTCCCGCACCAAATCTGGATCCAAGTCTTCCATATGTGAGTCATCTTCCCTC
ATCTCCAGTGCCACAGCAGCAGCTCTACTGAGCTCTGGGGCTGTGGACTACTGCCTGCAC
GTGCTCAAATCACTGCTGGAATATTGGAAGAGCCAACAGAATGACGAGGAGCCTGTGGCT
ACCAGCCAGTTGCTGAAACCACATACTACCTCCTCCCCACCTGACATGAGCCCATTCTTT
CTCCGCCAGTATGTGAAGGGTCATGCTGCTGATGTGTTTGAGGCCTATACTCAGCTTCTA
ACAGAAATGGTACTGAGGCTTCCTTACCAAATCAAAAAGATTACTGACACCAATTCTCGA
ATCCCACCTCCTGTCTTTGACCACTCGTGGTTTTACTTTCTCTCCGAGTACCTCATGATC
CAGCAGACTCCATTTGTGCGCCGTCAAGTCCGCAAACTTCTGCTCTTCATCTGTGGATCC
AAAGAGAAGTACCGCCAGCTCCGGGATTTGCACACCCTGGACTCTCACGTGCGTGGGATC
AAGAAGCTGCTAGAAGAGCAGGGGATATTCCTCCGGGCAAGTGTGGTTACAGCCAGCTCA
GGCTCCGCCTTGCAATATGACACACTCATCAGCCTGATGGAGCACCTGAAAGCCTGTGCA
GAGATTGCCGCCCAGCGAACCATCAACTGGCAGAAATTCTGCATCAAAGATGACTCCGTC
CTGTACTTCCTCCTCCAAGTCAGTTTCCTTGTGGATGAGGGCGTGTCCCCAGTGCTGCTG
CAACTGCTCTCCTGTGCTCTGTGCGGCAGCAAGGTGCTCGCTGCACTGGCAGCCTCTTCG
GGATCCTCCAGTGCTTCTTCCTCCTCAGCCCCTGTGGCTGCCAGTTCTGGACAAGCCACA
ACACAGTCCAAGTCTTCCACTAAAAAGAGCAAGAAAGAAGAAAAAGAAAAGGAGAAAGAT
GGTGAGACCTCTGGCAGCCAGGAGGACCAGCTGTGCACAGCTCTGGTGAACCAGCTGAAC
AAATTTGCCGATAAGGAAACCCTGATCCAGTTCCTGCGTTGTTTCCTGTTAGAGTCCAAT
TCTTCCTCGGTGCGCTGGCAGGCCCACTGTCTGACACTGCACATCTACAGAAATTCCAGC
AAATCTCAACAGGAGCTCCTGCTAGATCTGATGTGGTCCATCTGGCCAGAACTCCCAGCC
TATGGTCGTAAGGCTGCCCAGTTTGTGGACCTACTAGGATATTTCTCCCTGAAAACTCCA
CAAACAGAGAAGAAGTTGAAGGAGTATTCACAGAAGGCTGTGGAGATTCTGCGGACTCAA
AACCATATTCTTACCAACCACCCCAACTCGAACATTTATAACACTTTGTCTGGCTTAGTG
GAGTTTGATGGCTATTACCTGGAGAGCGATCCCTGCCTGGTGTGTAATAACCCGGAAGTA
CCGTTCTGTTATATCAAGCTGTCTTCCATTAAAGTGGACACGCGGTACACCACCACCCAG
CAGGTTGTGAAGCTCATTGGCAGTCACACCATCAGCAAAGTGACAGTGAAAATCGGGGAT
CTGAAACGGACCAAGATGGTGCGGACCATCAACCTGTATTATAACAACCGAACCGTGCAG
GCCATCGTGGAGTTGAAAAACAAGCCAGCTCGCTGGCACAAAGCCAAGAAGGTTCAGCTG
ACCCCTGGACAGACAGAGGTGAAGATTGACCTGCCGTTGCCCATTGTGGCCTCCAATCTG
ATGATTGAGTTTGCAGACTTCTATGAAAACTACCAGGCCTCCACAGAGACCCTGCAGTGC
CCTCGCTGTAGTGCCTCGGTCCCTGCCAACCCAGGAGTCTGTGGCAACTGTGGAGAGAAT
GTGTACCAGTGTCACAAATGCAGATCCATCAACTACGATGAAAAGGATCCCTTCCTCTGC
AATGCCTGTGGCTTCTGTAAATATGCCCGCTTCGACTTCATGCTCTATGCCAAGCCTTGC
TGTGCAGTGGATCCCATTGAGAATGAAGAAGACCGGAAGAAGGCTGTATCCAACATCAAT
ACACTTTTGGACAAAGCTGATCGAGTGTATCATCAGCTGATGGGACACCGGCCACAGCTG
GAGAACCTGCTCTGCAAAGTGAATGAGGCAGCTCCAGAAAAGCCACAGGATGACTCAGGA
ACAGCAGGGGGCATCAGCTCCACTTCTGCCAGTGTGAATCGTTACATCCTGCAGTTGGCT
CAGGAGTATTGTGGAGACTGCAAGAACTCTTTTGATGAACTCTCCAAAATCATCCAGAAA
GTCTTTGCTTCGCGCAAAGAGTTGTTGGAATATGACCTACAGCAGAGGGAAGCAGCCACT
AAATCATCCCGGACCTCCGTGCAGCCCACATTCACTGCCAGCCAGTACCGTGCCTTATCC
GTCCTGGGCTGTGGCCACACATCCTCCACCAAGTGCTATGGCTGCGCCTCGGCTGTCACA
GAACATTGTATCACACTACTTCGGGCCCTGGCCACCAACCCAGCCTTGAGGCACATCCTT
GTCTCCCAGGGCCTTATCCGGGAGCTCTTTGATTATAATCTTCGCCGAGGGGCTGCGGCC
ATGCGGGAGGAGGTCCGCCAGCTCATGTGCCTCCTAACTCGAGACAACCCAGAAGCCACC
CAACAGATGAATGACCTGATTATTGGCAAGGTCTCCACAGCCCTGAAGGGCCACTGGGCC
AACCCCGATCTGGCAAGTAGCCTGCAGTATGAAATGCTGCTGCTGACGGATTCTATCTCC
AAGGAGGACAGCTGCTGGGAGCTCCGGTTACGCTGTGCTCTCAGCCTTTTCCTCATGGCT
GTGAACATTAAGACTCCTGTGGTGGTTGAAAACATTACCCTCATGTGCCTGAGGATCTTG
CAGAAGCTGATAAAACCACCTGCTCCCACTAGCAAGAAGAACAAGGATGTCCCCGTTGAG
GCCCTCACCACGGTGAAGCCATACTGCAATGAGATCCATGCCCAGGCTCAACTGTGGCTC
AAGAGAGACCCCAAGGCATCCTATGATGCCTGGAAGAAGTGTCTTCCTATCAGAGGGATA
GATGGCAATGGGAAAGCCCCCAGCAAATCAGAGCTCCGCCATCTCTATTTGACTGAGAAG
TATGTGTGGAGGTGGAAACAGTTCCTGAGTCGTCGGGGGAAGAGGACCTCCCCCTTGGAT
CTCAAACTGGGGCATAACAACTGGCTGCGACAAGTGCTTTTCACTCCAGCAACGCAGGCC
GCACGGCAGGCAGCCTGTACCATTGTGGAAGCTCTAGCCACCATTCCCAGCCGCAAGCAG
CAGGTCCTGGACCTGCTTACCAGTTACCTGGATGAGCTGAGCATAGCTGGGGAGTGTGCA
GCTGAGTACCTGGCTCTCTACCAGAAGCTCATCACTTCTGCGCACTGGAAAGTCTACTTG
GCAGCTCGGGGAGTCCTACCCTATGTGGGCAACCTCATCACCAAGGAAATAGCTCGTCTG
CTGGCCCTGGAGGAGGCTACCCTGAGTACCGATCTGCAGCAGGGTTATGCCCTTAAAAGT
CTCACAGGCCTTCTCTCCTCCTTTGTTGAGGTGGAATCCATCAAAAGACATTTTAAAAGT
CGCTTGGTGGGTACTGTGCTGAATGGATACCTGTGCTTGCGGAAGCTGGTGGTGCAGAGG
ACCAAGCTGATCGATGAGACGCAGGACATGCTGCTGGAGATGCTGGAGGACATGACCACA
GGTACAGAATCAGAAACCAAGGCCTTCATGGCTGTGTGCATTGAGACAGCCAAGCGCTAC
AATCTGGATGACTACCGGACCCCGGTGTTCATCTTCGAGAGGCTCTGCAGCATCATTTAT
CCTGAGGAGAATGAAGTCACTGAGTTCTTTGTGACCCTGGAGAAGGATCCCCAACAAGAA
GACTTCTTACAGGGCAGGATGCCTGGGAACCCGTATAGCAGCAATGAGCCAGGCATCGGG
CCGCTGATGAGGGATATAAAGAACAAGATTTGCCAGGACTGTGACTTAGTGGCCCTCCTG
GAAGATGACAGTGGCATGGAGCTTCTAGTGAACAATAAAATCATTAGTTTGGACCTTCCT
GTGGCTGAAGTTTACAAGAAAGTCTGGTGTACCACGAATGAGGGAGAGCCCATGAGGATT
GTTTATCGTATGCGGGGGCTGCTGGGCGATGCCACAGAGGAGTTCATTGAGTCCCTGGAC
TCTACTACAGATGAAGAAGAAGATGAAGAAGAAGTGTATAAAATGGCTGGTGTGATGGCC
CAGTGTGGGGGCCTGGAATGCATGCTTAACAGACTCGCAGGGATCAGAGATTTCAAGCAG
GGACGCCACCTTCTAACAGTGCTACTGAAATTGTTCAGTTACTGCGTGAAGGTGAAAGTC
AACCGGCAGCAACTGGTCAAACTGGAAATGAACACCTTGAACGTCATGCTGGGGACCCTA
AACCTGGCCCTTGTAGCTGAACAAGAAAGCAAGGACAGTGGGGGTGCAGCTGTGGCTGAG
CAGGTGCTTAGCATCATGGAGATCATTCTAGATGAGTCCAATGCTGAGCCCCTGAGTGAG
GACAAGGGCAACCTCCTCCTGACAGGTGACAAGGATCAACTGGTGATGCTCTTGGACCAG
ATCAACAGCACCTTTGTTCGCTCCAACCCCAGTGTGCTCCAGGGCCTGCTTCGCATCATC
CCGTACCTTTCCTTTGGAGAGGTGGAGAAAATGCAGATCTTGGTGGAGCGATTCAAACCA
TACTGCAACTTTGATAAATATGATGAAGATCACAGTGGTGATGATAAAGTCTTCCTGGAC
TGCTTCTGTAAAATAGCTGCTGGCATCAAGAACAACAGCAATGGGCACCAGCTGAAGGAT
CTGATTCTCCAGAAGGGGATCACCCAGAATGCACTTGACTACATGAAAAAGCACATCCCT
AGCGCCAAGAATTTGGATGCCGACATCTGGAAAAAGTTTTTGTCTCGCCCAGCCTTGCCA
TTTATCCTAAGGCTGCTTCGGGGCCTGGCCATCCAGCACCCTGGCACCCAGGTTCTGATT
GGAACTGATTCCATCCCGAACCTGCATAAGCTGGAGCAGGTGTCCAGTGATGAGGGCATT
GGGACCTTGGCAGAGAACCTGCTGGAAGCCCTGCGGGAACACCCTGACGTAAACAAGAAG
ATTGACGCAGCCCGCAGGGAGACCCGGGCAGAGAAGAAGCGCATGGCCATGGCAATGAGG
CAGAAGGCCCTGGGCACCCTGGGCATGACGACAAATGAAAAGGGCCAGGTCGTGACCAAG
ACAGCACTCCTGAAGCAGATGGAAGAGCTGATCGAGGAGCCTGGCCTCACGTGCTGCATC
TGCAGGGAGGGATACAAGTTCCAGCCCACAAAGGTCCTGGGCATTTATACCTTCACGAAG
CGGGTAGCCTTGGAGGAGATGGAGAATAAGCCCCGGAAACAGCAGGGCTACAGCACCGTG
TCCCACTTCAACATTGTGCACTACGACTGCCATCTGGCTGCCGTCAGGTTGGCTCGAGGC
CGGGAAGAGTGGGAGAGTGCCGCCCTGCAGAATGCCAACACCAAGTGCAACGGGCTCCTT
CCGGTCTGGGGACCTCATGTCCCTGAATCAGCTTTTGCCACTTGCTTGGCAAGACACAAC
ACTTACCTCCAGGAATGTACAGGCCAGCGGGAGCCCACGTATCAGCTCAACATCCATGAC
ATCAAACTGCTCTTCCTGCGCTTCGCCATGGAGCAGTCGTTCAGCGCAGACACTGGCGGG
GGCGGCCGGGAGAGCAACATCCACCTGATCCCGTACATCATTCACACTGTGCTTTACGTC
CTGAACACAACCCGAGCAACTTCCCGAGAAGAGAAGAACCTCCAAGGCTTTCTGGAACAG
CCCAAGGAGAAGTGGGTGGAGAGTGCCTTTGAAGTGGACGGGCCCTACTATTTCACAGTC
TTGGCCCTTCACATCCTGCCCCCTGAGCAGTGGAGAGCCACACGTGTGGAAATCTTGCGG
AGGCTGTTGGTGACCTCGCAGGCTCGGGCAGTGGCTCCAGGTGGAGCCACCAGGCTGACA
GATAAGGCAGTGAAGGACTATTCCGCTTACCGTTCTTCCCTTCTCTTTTGGGCCCTCGTC
GATCTCATTTACAACATGTTTAAGAAGGTGCCTACCAGTAACACAGAGGGAGGCTGGTCC
TGCTCTCTCGCTGAGTACATCCGCCACAACGACATGCCCATCTACGAAGCTGCCGACAAA
GCCCTGAAAACCTTCCAGGAGGAGTTCATGCCAGTGGAGACCTTCTCAGAGTTCCTCGAT
GTGGCCGGTCTTTTATCAGAAATCACCGATCCAGAGAGCTTCCTGAAGGACCTGTTGAAC
TCAGTCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 5183 |
| Molecular Weight
| 573835.3 |
| Theoretical pI
| 5.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase UBR4
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESE
SEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDE
ACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFI
AQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFH
SLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFL
ILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHA
IKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLST
SYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS
PSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITS
SMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTS
DLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECL
KVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQEL
SVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNS
RRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKL
VKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYI
NQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKC
SSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFS
KMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAA
VLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSES
YISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEEC
LQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEK
SPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIV
RENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAA
VDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSH
LSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCH
TCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTM
KESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQ
NQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMV
PTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGK
ITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTF
SSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFL
LPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLK
DSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKT
SPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHT
ACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTR
TSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEI
SNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKK
LNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTG
DSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPAS
VQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSI
AIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNA
FLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQA
LIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQS
EVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAI
ALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGS
TLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAI
STTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYM
QVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLS
VFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVA
TSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSR
IPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGI
KKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSV
LYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQAT
TQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESN
SSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTP
QTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEV
PFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQ
AIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQC
PRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPC
CAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSG
TAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAAT
KSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHIL
VSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWA
NPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRIL
QKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGI
DGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYL
AARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKS
RLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIG
PLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRI
VYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAE
QVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRII
PYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLI
GTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMR
QKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLL
PVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGG
GGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALV
DLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLD
VAGLLSEITDPESFLKDLLNSVP
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| External Links |
|---|
| GenBank ID Protein
| 82659109 |
| UniProtKB/Swiss-Prot ID
| Q5T4S7 |
| UniProtKB/Swiss-Prot Entry Name
| UBR4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020765.2 |
| GeneCard ID
| UBR4 |
| GenAtlas ID
| UBR4 |
| HGNC ID
| HGNC:30313 |
| References |
|---|
| General References
| Not Available |