Identification |
HMDB Protein ID
| CDBP02603 |
Secondary Accession Numbers
| Not Available |
Name
| Probable cysteine--tRNA ligase, mitochondrial |
Description
| Not Available |
Synonyms
|
- CysRS
- Cysteine--tRNA ligase
- Cysteinyl-tRNA synthetase
|
Gene Name
| CARS2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotide binding |
Specific Function
| Not Available |
GO Classification
|
Biological Process |
cysteinyl-tRNA aminoacylation |
Cellular Component |
cytosol |
mitochondrial matrix |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
ligase activity |
ligase activity, forming carbon-oxygen bonds |
ligase activity, forming aminoacyl-trna and related compounds |
aminoacyl-trna ligase activity |
cysteine-trna ligase activity |
binding |
nucleotide binding |
catalytic activity |
Molecular Function |
metal ion binding |
ATP binding |
cysteine-tRNA ligase activity |
Process |
trna aminoacylation for protein translation |
macromolecule biosynthetic process |
cellular macromolecule biosynthetic process |
translation |
cysteinyl-trna aminoacylation |
metabolic process |
macromolecule metabolic process |
cellular macromolecule metabolic process |
biosynthetic process |
rna metabolic process |
ncrna metabolic process |
trna metabolic process |
trna aminoacylation |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Cysteine Metabolism | | | Aminoacyl-tRNA biosynthesis | Not Available | |
|
Gene Properties |
Chromosome Location
| 13 |
Locus
| 13q34 |
SNPs
| CARS2 |
Gene Sequence
|
>1695 bp
ATGTTGAGGACTACGCGCGGCCCAGGCCTGGGCCCCCCGCTGCTCCAGGCCGCGCTGGGC
CTTGGGCGGGCTGGGTGGCACTGGCCTGCGGGCCGGGCGGCGAGCGGGGGGCGCGGGCGG
GCCTGGCTGCAGCCCACGGGCCGGGAGACGGGTGTGCAGGTGTACAACAGCCTCACCGGG
AGGAAGGAACCCCTAATCGTGGCGCACGCCGAAGCCGCCTCCTGGTATAGCTGTGGACCA
ACTGTATATGATCATGCGCACCTTGGCCATGCTTGCTCATATGTTAGATTTGATATCATT
CGAAGGATCCTAACCAAGGTTTTTGGATGCAGCATAGTCATGGTGATGGGTATTACAGAT
GTAGATGATAAAATCATCAAAAGAGCCAATGAGATGAATATTTCCCCCGCTTCCCTCGCC
AGTCTTTATGAGGAAGACTTCAAGCAGGACATGGCAGCCCTGAAGGTTCTCCCACCCACG
GTGTACCTGAGGGTAACCGAAAATATTCCTCAGATAATTTCTTTCATTGAAGGAATCATT
GCTCGTGGGAACGCTTATTCAACGGCAAAAGGCAATGTCTACTTCGATCTGAAGTCTAGA
GGAGACAAGTATGGCAAATTGGTCGGCGTGGTCCCTGGTCCAGTCGGAGAGCCAGCGGAC
TCTGACAAGCGTCATGCCAGTGACTTCGCCCTGTGGAAGGCGGCCAAACCCCAGGAGGTG
TTCTGGGCCTCTCCCTGGGGACCCGGGAGGCCGGGCTGGCACATCGAGTGCTCTGCCATC
GCTAGTATGGTATTTGGAAGTCAACTGGATATCCATTCAGGTGGGATAGATTTAGCTTTT
CCACATCATGAGAACGAAATTGCACAGTGCGAAGTCTTTCATCAGTGCGAGCAGTGGGGA
AATTATTTTCTGCATTCTGGGCATTTGCACGCCAAAGGCAAAGAAGAAAAAATGTCCAAA
TCATTAAAGAACTACATTACTATTAAGGACTTTCTGAAGACCTTTTCCCCCGATGTCTTC
CGGTTCTTCTGCCTGCGGAGCAGCTACCGCTCAGCCATCGACTACAGTGACAGCGCCATG
CTCCAAGCTCAGCAGCTGCTCCTGGGGCTGGGCTCTTTCCTGGAGGACGCACGTGCCTAC
ATGAAGGGGCAGCTGGCCTGCGGCTCCGTCAGGGAAGCGATGCTGTGGGAGAGGCTCTCC
AGCACCAAGAGGGCCGTGAAGGCGGCCTTGGCAGATGATTTTGACACACCCAGGGTGGTT
GATGCCATCCTGGGCCTTGCACACCACGGGAATGGACAGCTCAGGGCGTCCCTGAAGGAA
CCTGAAGGGCCGAGAAGTCCTGCTGTGTTTGGTGCCATCATCTCTTACTTTGAACAGTTT
TTTGAAACTGTTGGAATTTCTCTGGCAAATCAACAGTACGTTTCAGGAGACGGCAGCGAG
GCTACCTTGCATGGTGTGGTGGACGAGCTGGTGCGGTTCCGGCAGAAGGTCCGGCAGTTT
GCGCTGGCCATGCCCGAGGCCACGGGGGACGCCCGGCGGCAGCAGCTCCTAGAAAGGCAG
CCCCTGCTGGAAGCATGCGACACCCTGCGCCGGGGCCTGACTGCCCACGGCATCAACATC
AAGGACAGAAGCAGTACAACATCCACGTGGGAACTGCTGGATCAAAGGACAAAAGACCAA
AAATCAGCGGGCTGA
|
Protein Properties |
Number of Residues
| 564 |
Molecular Weight
| 62223.345 |
Theoretical pI
| 8.334 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Probable cysteinyl-tRNA synthetase, mitochondrial
MLRTTRGPGLGPPLLQAALGLGRAGWHWPAGRAASGGRGRAWLQPTGRETGVQVYNSLTG
RKEPLIVAHAEAASWYSCGPTVYDHAHLGHACSYVRFDIIRRILTKVFGCSIVMVMGITD
VDDKIIKRANEMNISPASLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGII
ARGNAYSTAKGNVYFDLKSRGDKYGKLVGVVPGPVGEPADSDKRHASDFALWKAAKPQEV
FWASPWGPGRPGWHIECSAIASMVFGSQLDIHSGGIDLAFPHHENEIAQCEVFHQCEQWG
NYFLHSGHLHAKGKEEKMSKSLKNYITIKDFLKTFSPDVFRFFCLRSSYRSAIDYSDSAM
LQAQQLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALADDFDTPRVV
DAILGLAHHGNGQLRASLKEPEGPRSPAVFGAIISYFEQFFETVGISLANQQYVSGDGSE
ATLHGVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRRGLTAHGINI
KDRSSTTSTWELLDQRTKDQKSAG
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9HA77 |
UniProtKB/Swiss-Prot Entry Name
| SYCM_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK022180 |
GeneCard ID
| CARS2 |
GenAtlas ID
| CARS2 |
HGNC ID
| HGNC:25695 |
References |
General References
| Not Available |