| Identification |
|---|
| HMDB Protein ID
| CDBP04448 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase RNF128 |
| Description
| Not Available |
| Synonyms
|
- Gene related to anergy in lymphocytes protein
- RING finger protein 128
|
| Gene Name
| RNF128 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- Endomembrane system
- perinuclear region
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| RNF128 |
| Gene Sequence
|
>1287 bp
ATGGGGCCGCTGCCTGGGGCCGGGGTCTCCTGCCGCGGTGGCTGCGGCTTTTCCAGATTG
CTGGCATGGTGCTTCCTGCTGGCCCTGAGTCCGCAGGCACCCGGTTCCCGGGGGGCTGAA
GCAGTGTGGACCGCGTACCTCAACGTGTCCTGGCGGGTTCCGCACACGGGAGTGAACCGT
ACGGTGTGGGAGCTGAGCGAGGAGGGCGTGTACGGCCAGGACTCGCCGCTGGAGCCTGTG
GCTGGGGTCCTGGTACCGCCCGACGGGCCCGGGGCGCTTAACGCCTGTAACCCGCACACG
AATTTCACGGTGCCCACGGTTTGGGGAAGCACCGTGCAAGTCTCTTGGTTGGCCCTCATC
CAACGCGGCGGGGGCTGCACCTTCGCAGACAAGATCCATCTGGCTTATGAGAGAGGGGCG
TCTGGAGCCGTCATCTTTAACTTCCCCGGGACCCGCAATGAGGTCATCCCCATGTCTCAC
CCGGGTGCAGTAGACATTGTTGCAATCATGATCGGCAATCTGAAAGGCACAAAAATTCTG
CAATCTATTCAAAGAGGCATACAAGTGACAATGGTCATAGAAGTAGGGAAAAAACATGGC
CCTTGGGTGAATCACTATTCAATTTTTTTCGTTTCTGTGCCCTTTTTTATTATTACGGNG
GCAACTGGGGGCTATTTTATCTTTTATTCTGCTCNAAGGCTACGGAATGCAAGANCTCAA
AGCNGGAAGCAGAGGCAATTAAAGGCAGATGCTAAAAAAGCTATTGGAAGGCTTCAACTA
CGCACACTGAAACAAGGAGACAAGGAAATTGGCCCTGATGGAGATAGTTGTGCTGTGTGC
ATTGAATTGTATAAACCAAATGATTTGGTACGCATCTTAACGTGCAACCATATTTTCCAT
AAGACATGTGTTGACCCATGGCTGTTAGAACACAGGACTTGCCCCATGTGCAAATGTGAC
ATACTCAAAGCTTTGGGAATTGAGGTGGATGTTGAAGATGGATCAGTGTCTTTACAAGTC
CCTGTATCCAATGAAATATCTAATAGTGCCTCCTCCCATGAAGAGGATAATCGCAGCGAG
ACCGCATCATCTGGATACGCTTCAGTACAGGGAACAGATGAACCGCCTCTGGAGGAACAC
GTGCAGTCAACAAATGAAAGTCTACAGCTGGTAAACCATGAAGCAAATTCTGTGGCAGTG
GATGTTATTCCTCATGTTGACAACCCAACCTTTGAAGAAGACGAAACTCCTAATCAAGAG
ACTGCTGTTCGAGAAATTAAATCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 428 |
| Molecular Weight
| 46520.4 |
| Theoretical pI
| 6.32 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase RNF128
MGPPPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNR
TVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALI
QRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKIL
QSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQ
SRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFH
KTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSE
TASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQE
TAVREIKS
|
| External Links |
|---|
| GenBank ID Protein
| 15011452 |
| UniProtKB/Swiss-Prot ID
| Q8TEB7 |
| UniProtKB/Swiss-Prot Entry Name
| RN128_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF394689 |
| GeneCard ID
| RNF128 |
| GenAtlas ID
| RNF128 |
| HGNC ID
| HGNC:21153 |
| References |
|---|
| General References
| Not Available |