Identification
HMDB Protein ID CDBP00568
Secondary Accession Numbers Not Available
Name Ubiquitin-conjugating enzyme E2 L3
Description Not Available
Synonyms
  1. L-UBC
  2. UbcH7
  3. Ubiquitin carrier protein L3
  4. Ubiquitin-conjugating enzyme E2-F1
  5. Ubiquitin-protein ligase L3
Gene Name UBE2L3
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
GO Classification
Biological Process
cell proliferation
ubiquitin-dependent protein catabolic process
protein K11-linked ubiquitination
regulation of S phase of mitotic cell cycle
cellular response to glucocorticoid stimulus
regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
ubiquitin ligase complex
cytoplasm
nucleus
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
transcription coactivator activity
enzyme binding
acid-amino acid ligase activity
Process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 22
Locus 22q11.21
SNPs UBE2L3
Gene Sequence
>465 bp
ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAA
AACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTT
CCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG
TACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGAC
GAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAA
ACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCG
CTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT
GAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA
Protein Properties
Number of Residues 154
Molecular Weight 24003.385
Theoretical pI 8.742
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-conjugating enzyme E2 L3
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P68036
UniProtKB/Swiss-Prot Entry Name UB2L3_HUMAN
PDB IDs
GenBank Gene ID S81003
GeneCard ID UBE2L3
GenAtlas ID UBE2L3
HGNC ID HGNC:12488
References
General References Not Available