| Identification |
|---|
| HMDB Protein ID
| CDBP04425 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase FANCL |
| Description
| Not Available |
| Synonyms
|
- FAAP43
- Fanconi anemia group L protein
- Fanconi anemia-associated polypeptide of 43 kDa
|
| Gene Name
| FANCL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth |
| GO Classification
|
| Function |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p16.1 |
| SNPs
| FANCL |
| Gene Sequence
|
>1128 bp
ATGGCGGTGACGGAAGCGAGCCTGTTGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGG
TCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATA
GTGTTGCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGA
ACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAGCACTCTCCTGATCTA
ATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAG
CTGTATGCACTACCTCCTCCTCCCCAGTTCTACTCAAGCCTTATTGAAGAGATAGGAACT
CTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCA
GAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCA
GAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAG
AGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTC
TGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCA
CGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTA
GACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTA
AAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGGATCCAGAAAATAGTGTG
TTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAA
TCTGATTTTACTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCT
GATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAG
TGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCA
TATTGTAGTAAGCCAATTACCTTAAAAATGTCTGGAAGGAAACACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 375 |
| Molecular Weight
| 42904.2 |
| Theoretical pI
| 6.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase FANCL
MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLR
TILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQELYALPPPPQFYSSLIEEIGT
LGWDKLVYADTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQ
SSLISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEV
DPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEK
SDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECP
YCSKPITLKMSGRKH
|
| External Links |
|---|
| GenBank ID Protein
| 62822472 |
| UniProtKB/Swiss-Prot ID
| Q9NW38 |
| UniProtKB/Swiss-Prot Entry Name
| FANCL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC007250 |
| GeneCard ID
| FANCL |
| GenAtlas ID
| FANCL |
| HGNC ID
| HGNC:20748 |
| References |
|---|
| General References
| Not Available |