Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 J1 (CDBP00609)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00609

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 J1

Description

Not Available

Synonyms

HsUBC6e
NCUBE-1
Non-canonical ubiquitin-conjugating enzyme 1
Yeast ubiquitin-conjugating enzyme UBC6 homolog E

Gene Name

UBE2J1

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

GO Classification

Biological Process
ER-associated protein catabolic process
protein N-linked glycosylation via asparagine
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process

Cellular Location

Endoplasmic reticulum membrane
Single-pass type IV membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available
Protein processing in endoplasmic reticulum	Not Available
Parkinson's disease	Not Available

Gene Properties

Chromosome Location

Locus

6q15

SNPs

UBE2J1

Gene Sequence

>957 bp
ATGGAGACCCGCTACAACCTGAAGAGTCCGGCTGTTAAACGTTTAATGAAAGAAGCGGCA
GAATTGAAAGATCCAACAGATCATTACCATGCGCAGCCTTTAGAGGATAACCTTTTTGAA
TGGCACTTCACGGTTAGAGGGCCCCCAGACTCCGATTTTGATGGAGGAGTTTATCACGGG
CGGATAGTACTGCCACCAGAGTATCCCATGAAACCACCAAGCATTATTCTCCTAACGGCT
AATGGTCGATTTGAAGTGGGCAAGAAAATCTGTTTGAGCATCTCAGGCCATCATCCTGAA
ACTTGGCAGCCTTCGTGGAGTATAAGGACAGCATTATTAGCCATCATTGGGTTTATGCCA
ACAAAAGGAGAGGGAGCCATAGGTTCTCTAGATTACACTCCTGAGGAAAGAAGAGCACTT
GCCAAAAAATCACAAGATTTCTGTTGTGAAGGATGTGGCTCTGCCATGAAGGATGTCCTG
TTGCCTTTAAAATCTGGAAGCGATTCAAGCCAAGCTGACCAAGAAGCCAAAGAACTGGCT
AGGCAAATAAGCTTTAAGGCAGAAGTCAATTCATCTGGAAAGACTATCTCTGAGTCAGAC
TTAAACCACTCTTTTTCACTAACTGATTTACAAGATGATATACCTACAACATTCCAGGGT
GCTACGGCCAGTACATCGTACGGACTCCAGAATTCCTCAGCAGCATCCTTTCATCAACCT
ACCCAACCTGTAGCTAAGAATACCTCCATGAGCCCTCGACAGCGCCGGGCCCAGCAGCAG
AGTCAGAGAAGGTTGTCTACTTCACCAGATGTAATCCAGGGCCACCAGCCAAGAGACAAC
CACACTGATCATGGTGGGTCAGCTGTACTGATTGTCATCCTGACTTTGGCATTGGCAGCT
CTTATATTCCGACGAATATATCTGGCAAACGAATACATATTTGACTTTGAGTTATAA

Protein Properties

Number of Residues

318

Molecular Weight

35198.275

Theoretical pI

6.748

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 J1
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHG
RIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMP
TKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELA
RQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQP
TQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHTDHGGSAVLIVILTLALAA
LIFRRIYLANEYIFDFEL

External Links

GenBank ID Protein

37577122

UniProtKB/Swiss-Prot ID

Q9Y385

UniProtKB/Swiss-Prot Entry Name

UB2J1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_016021.2

GeneCard ID